Antioxidant lignans from the seeds of Vitex negundo var. cannabifolia

Abstract

A new phenyldihydronaphthalene-type lignan, vitexdoin F (1), along with 22 known lignan derivatives (2-23) was isolated from the seeds of Vitex negundo var. cannabifolia. Their structures were established by comprehensive 1D and 2D NMR spectroscopic analyses. The antioxidant activities of these lignans were evaluated through 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assays, and 16 of these isolates exhibited obvious radical-scavenging effect on the stable-free radical, DPPH.

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

“…Within the Lamiaceae family, surely negundins A-B ( Figure 20) are chemotaxonomic markers for the species Vitex negundo L given their occurrence in several exemplars of this species [69][70][71].…”

<em>Nor</em>-Lignans: Occurrence in Plants and Biological Activities - A Review

“…Within the Lamiaceae family, surely negundins A-B are chemotaxonomic markers for the species Vitex negundo L given their occurrence in several exemplars of this species [69][70][71].…”

“…Nyasol exerts medium effects against ABTS •+ cation and superoxide anion radicals with IC50 values equal to 45.6 and 40.5 μM, respectively [82]. Vitexdoin F, vitedoin A, 6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7methoxy-3,4-dihydro-2-naphthaldehyde, vitexdoin A, negundin B, vitexdoin E, vitrofolal F, 1,2-dihydro-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-6-methoxy-(1S,2R)-2-naphthalenecarboxaldehyde, vitexdoin C, vitexdoin D, vitrofolal E, vitexdoin B,vitrofolal A, detetrahydro-conidendrin showed stronger effects than ascorbic acid[69,73].…”

Chemical constituents and their bioactivities from the fruits of Vitex negundo var. cannabifolia

“…Vitex negundo var. cannabifolia is an aromatic shrub which grows extensively throughout China, Japan, South Asia, East Africa and South America (Lou et al 2014). The fresh leaves of this plant were used in traditional Chinese medicine for the treatment of asthma, influenza, analgesia and gastralgia (The State Pharmacopoeia Commission of People's Republic of China's 2010).…”

“…Considering insufficient phytochemical studies about V. negundo var. cannabifolia Lou et al 2014), and our continuing search for bioactive constituents of the medicinal plants, the chemical constituents of the fruits of V. negundo var. cannabifolia had been investigated.…”