Antioxidant-Induced Stress

Villanueva, Cleva; Kross, Robert David

doi:10.3390/ijms13022091

Cited by 131 publications

(109 citation statements)

References 95 publications

(139 reference statements)

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“…In our rat model we observed that exogenous administration of ascorbic acid and blueberry extract restored GR activity, reduced lipoperoxidation and hypospermatogenesis typical of hypobaric hypoxic exposure (Farias et al, 2010;Zepeda et al, 2012). However, the clinical translation of antioxidant therapies has proven diffi cult, as few benefi ts and even harmful eff ects (Dotan et al, 2009) have been observed in clinical trials aimed to reduce oxidative stress by antioxidant supplementation (Armitage et al, 2009;Villanueva and Kross, 2012).…”

Section: Oxidative Stressmentioning

confidence: 93%

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Farías

Jiménez²,

Osorio³

et al. 2013

Biol. Res.

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In the past two decades, Chile has developed intense mining activity in the Andes mountain range, whose altitude is over 4,000 meters above sea level. It is estimated that a workforce population of over 55,000 is exposed to high altitude hypobaric hypoxia. The miners work under shift systems which vary from 4 to 20 days at the worksite followed by rest days at sea level, in a cycle repeated for several years. This Chronic Intermittent Hypoxia (CIH) constitutes an unusual condition for workers involving a series of changes at the physiological, cellular and molecular levels attempting to compensate for the decrease in the environmental partial pressure of oxygen (PO 2 ). The mine worker must become acclimatized to CIH, and consequently undergoes an acute acclimatization process when he reaches the worksite and an acute reverse process when he reaches sea level. We have observed that after a period of 3 to 8 years of CIH exposure workers acclimatize well, and evidence from our studies and those of others indicates that CIH induces acute and chronic multisystem adjustments which are eff ective in off setting the reduced availability of oxygen at high altitudes. The aims of this review are to summarize fi ndings of the physiological responses to CIH exposure, highlighting outstanding issues in the fi eld.

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Section: Oxidative Stressmentioning

confidence: 93%

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Farías

Jiménez²,

Osorio³

et al. 2013

Biol. Res.

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“…Additional recent experiments by others (15) have questioned the role of antioxidant supplementations, suggesting that introduction of antioxidants may cause antioxidant-induced stress whereby these compounds overwhelm the body's free radical production disrupting cellular redox balance. Many investigators report benefits of antioxidant administration however there are only a few that question the possible harmful effects (16).…”

Section: Is Antioxidant Therapy Beneficial?mentioning

confidence: 99%

“…However, it has been reported that ROS and RNS participate in specific functions and play an important role in signal transduction in many physiological events (1-3, 9,10). ROS and RNS play a significant role in signal transduction of cytokine receptors, tyrosine receptors, serine/threonine kinases, G proteincoupled receptors, ion-channel linked receptors in response to angiotension II, cytokines, glutamate, epidermal growth factor, vascular endothelial growth factor, tumour necrosis factor alpha and platelet derived growth factor (15,16). Furthermore, hydrogen peroxide is a known mitogen (1).…”

Section: Is Antioxidant Therapy Beneficial?mentioning

confidence: 99%

Reactive oxygen species in disease: Rebuttal of a conventional concept

Vitetta

Coulson

Linnane

2015

jcbmr

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The production of intracellular reactive oxygen species and reactive nitrogen species has long been proposed as leading to the random deleterious modification of macromolecules (i.e., nucleic acids, proteins) with an associated progressive development of the age associated systemic diseases (e.g., diabetes, Parkinson's disease) as well as contributing to the ageing process. Superoxide anion (hydrogen peroxide) and nitric oxide (peroxynitrite) comprise regulated intracellular second messenger pro-oxidant systems, with specific sub-cellular locales of production and are essential for the normal function of the metabolome and cellular electro-physiology. We have posited that the formation of superoxide anion and its metabolic product hydrogen peroxide, and nitric oxide, do not conditionally lead to random damage of macromolecular species such as nucleic acids or proteins. Under normal physiological conditions their production is intrinsically regulated that is very much consistent with their second messenger purpose of function. We further propose that the concept of an orally administered small molecule antioxidant as a therapy to abrogate free radical activity (to control oxidative stress) is a chimera. As such we consider that free radicals are not a major overwhelming player in the development of the chronic diseases or the ageing process.

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“…At the present moment, there is majority opinion that antioxidants are good for human health but very recently some researchers are in the opinion that it may not be good for human health universally [1].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants: Friend or foe for tuberculosis patients

Bhattacharyya¹,

Banerjee²

2013

ABB

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Respiratory burst induced bacteria killing by oxidants are important mechanism of host defence. However, it is impaired in tuberculosis due to inhibition of respiratory burst by Mycobacterial factors. Antioxidants are compounds that cause chelation of reactive oxygen species. So, antioxidants are expected to play a negative role in the management of active tuberculosis. But, oxidative stress is a proved fact that invariably happens in tuberculosis patients which is known to cause immunosuppression. Immunosuppression in turn is expected to augment tuberculosis. Hence, antioxidant supplementation is expected to benefit tuberculosis patients by minimising oxidative stress induced immunosuppression. Therefore, the role of antioxidants in tuberculosis appears to be paradoxical and urgent. Understanding of the role of antioxidant supplementation in tuberculosis is warranted. It is in this context that we have reviewed the recent literature and addressed the problem for its solution.

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Antioxidant-Induced Stress

Cited by 131 publications

References 95 publications

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Reactive oxygen species in disease: Rebuttal of a conventional concept

Antioxidants: Friend or foe for tuberculosis patients

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