Antioxidant functions of carotenoids

Krinsky, Norman I.

doi:10.1016/0891-5849(89)90143-3

Cited by 846 publications

(388 citation statements)

References 93 publications

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“…BC possesses a wide array of pharmacological and biological activities including: antioxidant, radioprotective, cardiovascular protection, antiepilepsy [15][16][17][18][19]. Previous studies have demonstrated protective action of BC against some toxicants including Fenvalerate, metotroxate and Cadmium [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Orazizadeh

Khorsandi

Absalan

et al. 2014

J Assist Reprod Genet

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Objective This study evaluated the protective effect of betacarotene (BC) on titanium oxide nanoparticle (TNP) induced spermatogenesis defects in mice. Materials and methods Thirty-two NMRI mice were randomly divided into four groups. BC group received 10 mg/kg of BC for 35 days. TNP group received 300 mg/kg TNP for 35 days. TNP+BC group initially received 10 mg/kg BC for 10 days and was followed by concomitant administration of 300 mg/kg TNP for 35 days. Control group received only normal saline for 35 days. Epididymal sperm parameters, testicular histopathology, spermatogenesis assessments and testosterone assay were performed for evaluation of the TNP and BC effects on testis. Results Serum testosterone levels were markedly decreased in TNP-intoxicated mice. Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in TNP-intoxicated mice (p < 0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ cells and detachment were significantly increased in TNP-intoxicated mice (p<0.001). BC+TNP treatment significantly prevented these changes (p<0.05). BC also significantly elevates testosterone levels in BC+TNP group compared to TNP-treated mice (p<0.01). Discussion and conclusion The results of this study demonstrated that BC improved the spermatogenesis defects in TNPtreated mice. BC had a potent protective effect against the testicular toxicity and might be clinically useful.

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Section: Introductionmentioning

confidence: 99%

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Orazizadeh

Khorsandi

Absalan

et al. 2014

J Assist Reprod Genet

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“…Over 600 carotenoids have been isolated from natural sources [1]. Vertebrates and invertebrates cannot synthesize carotenoids, but they can ingest them in their diet and subsequently utilize them for important physiological functions [4,5]. The earliest role established for carotenes in animals was as a vitamin A precursor, typically by way of cleavage of the polyene carotenoid backbone to form one or two functional retinoid molecules.…”

Section: Introductionmentioning

confidence: 99%

Vertebrate and invertebrate carotenoid-binding proteins

Bhosale

Bernstein

2007

Archives of Biochemistry and Biophysics

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In invertebrates and vertebrates, carotenoids are ubiquitous colorants, antioxidants, and provitamin A compounds that must be absorbed from dietary sources and transported to target tissues where they are taken up and stabilized to perform their physiological functions. These processes occur in a specific and regulated manner mediated by high-affinity carotenoid-binding proteins. In this minireview, we examine the published literature on carotenoid-binding proteins in vertebrate and invertebrate systems, and we report our initial purification and characterization of a novel luteinbinding protein isolated from liver of Japanese quail (Coturnix japonica).

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“…In contrast, there is considerable in vitro evidence for interaction of 13-carotene with free radicals [1][2][3][4][5], for its properties as a chain-breaking antioxidant [2] and in scavenging and quenching singlet oxygen [6][7][8][9]. 13-Carotene has also been reported to protect against photosensitivity diseases in humans [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of carotenes and xanthophylls

et al. 1996

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The purpose of this study was to assess the relative antioxidant activities of a range of carotenes and xanthophylls through the extent of their abilities to scavenge the ABTS "+ radical cation. The results show that the relative abilities of the carotenoids to scavenge the ABTS "÷ radical cation are influenced by the presence of functional groups with increasing polarities, such as carbonyl and hydroxyl groups, in the terminal rings, as well as by the number of conjugated double bonds.

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Antioxidant functions of carotenoids

Cited by 846 publications

References 93 publications

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice

Vertebrate and invertebrate carotenoid-binding proteins

Antioxidant activities of carotenes and xanthophylls

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