Antioxidant functionalized polymer capsules to prevent oxidative stress

Larrañaga, Aitor; Isa, Isma Liza Mohd; Patil, Vaibhav; Thamboo, Sagana; Lomora, Mihai; Fernández‐Yagüe, Marc A.; Sarasua, Jose‐Ramon; Palivan, Cornelia G.; Pandit, Abhay

doi:10.1016/j.actbio.2017.12.014

Cited by 58 publications

(53 citation statements)

References 86 publications

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“…A wide variety of enzymatic reactions have been performed in the polymer capsules. The PAH/DS/TA microcapsules exhibited an excellent scavenging capacity for hydrogen peroxide and hydroxyl radical, suggesting better antioxidant properties [188]. Catalase enzyme encapsulated in the capsules was used to prevent oxidative stress in an in vitro inflammation model depicting that the PE shell can make encapsulated enzymes more stable compared to free enzymes.…”

Section: Bioreactorsmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

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Section: Bioreactorsmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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“…Reports to date include the encapsulation of antioxidant enzymes within several carriers including liposomes, 10 polymersomes, 11 polymer capsules 12 or mesoporous silica particles. 13 While these encapsulation platforms have successfully demonstrated the ability to sustain enzymatic reactions, even within the complex intracellular environment, [11][12][13] it is worth noticing that such architectures are typically fabricated by a single constituent material (i.e., lipids, polymers or silica). However, hybrid architectures composed of two different types of materials have emerged as an interesting alternative.…”

Section: Introductionmentioning

confidence: 99%

A dual-component carrier with both non-enzymatic and enzymatic antioxidant activity towards ROS depletion

et al. 2019

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“…The main limitations of small molecule antioxidants lie in their systemic distribution, rapid metabolism, and low retention at the diseased site, thereby resulting in low bioavailability in target tissues/cells. In this aspect, nanoparticles can protect the loaded small molecule antioxidants from hydrolysis, achieve site-specific delivery and controlled release of antioxidants at disease sites, and therefore improve their bioavailability ( Table 3) (Wang et al, 2015;Kang et al, 2016;Jung et al, 2018;Larrañaga et al, 2018;Gou et al, 2019). For example, our group fabricated a SOD/CAT-mimetic nanomedicine comprising H 2 O 2 -eliminating nanoparticles derived from a PBAP-conjugated β-CD material and a free radical scavenger Tempol .…”

Section: Drug-loaded Nanoparticles With Antioxidant Activitymentioning

confidence: 99%

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are essential in regulating various physiological functions. However, overproduction of ROS is implicated in the pathogenesis of various inflammatory diseases. Antioxidant therapy has thus represented an effective strategy for the treatment of oxidative stress relevant inflammatory diseases. Conventional anti-oxidative agents showed limited in vivo effects owing to their non-specific distribution and low retention in disease sites. Over the past decades, significant achievements have been made in the development of antioxidant nanotherapies that exhibit multiple advantages such as excellent pharmacokinetics, stable anti-oxidative activity, and intrinsic ROS-scavenging properties. This review provides a comprehensive overview on recent advances in antioxidant nanotherapies, including ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activity, and drug-loaded anti-oxidant nanoparticles. We highlight the biomedical applications of antioxidant nanotherapies in the treatment of different inflammatory diseases, with an emphasis on inflammatory bowel disease, cardiovascular disease, and brain diseases. Current challenges and future perspectives to promote clinical translation of antioxidant nanotherapies are also briefly discussed.

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Antioxidant functionalized polymer capsules to prevent oxidative stress

Cited by 58 publications

References 86 publications

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

A dual-component carrier with both non-enzymatic and enzymatic antioxidant activity towards ROS depletion

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

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