Antioxidant Flavonoid Glycoside from Leaves of Cacao Mistletoe (<i>Scurrula ferruginea</i> (Jack) Danser)

Abstract

Scurrula ferruginea (Jack) Danser is a folk medicine to treat several diseases. S. ferruginea is the mistletoe that lives by deriving nutrients from the host. Hence, the host has a significant effect on the biological activities and bioactive components of S. ferruginea. In this study, the leaves of S. ferruginea were macerated by methanol solvent to extract the chemical components and fractionated by hexane and ethyl acetate solvent, respectively, to separate organic compounds. The biological activity of crude extracts as the antioxidant was investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result showed that the highest antioxidant activity was obtained from the ethyl acetate fraction with the IC50 of 10.88 ± 0.39 µg/mL. Furthermore, the trituration method used several solvents to isolate secondary metabolites from the initial crude methanol extract. This purification process produced a flavonoid compound of quercitrin. The antioxidant activity of quercitrin was also determined by the DPPH method. The result showed that this compound has stronger activity than the crude extracts with the IC50 of 5.95 ± 0.11 µg/mL. This study demonstrated that cacao mistletoe of S. ferruginea may have the potential activity to treat the diseases caused by the presence of free radicals.

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“…Seiring dengan slogan back to nature, penggunaan obat tradisional di kalangan masyarakat sebagai alternatif pengobatan semakin meningkat. WHO menyatakan sekitar 80% penduduk di dunia menggunakan obat tradisional yang berasal dari tumbuhan [1]. Selain itu, kombinasi obat tradisional dan modern memiliki peran penting dalam meningkatkan sistem perawatan kesehatan.…”

“…Pengujian dilakukan dengan mengikuti metode studi sebelumnya [1,8] dengan sedikit modifikasi. Dimasukkan sampel yang akan diuji ke dalam tabung reaksi, ditambahkan dengan kloroform dan air suling perbandingan 1:1 sebanyak 5 mL, dilakukan pengocokan, kemudian didiamkan hingga terbentuk dua lapisan kloroform-air lapisan bawah merupakan lapisan kloroform, lapisan atas merupakan lapisan air.…”

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