Antioxidant enzymes in women with endometrial polyps: relation with sex hormones

Pejić, Snežana; Kasapović, Jelena; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša; Pajović, Snežana B.

doi:10.1016/j.ejogrb.2013.06.024

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Gür et al (2011) reported that ewes with two fetuses have lower values than ewes with a single fetus or that are not pregnant. In women, glutation activity has been observed to fall in postmenopausal women in comparison to the follicular and luteal (Pejic' et al 2013). There is also a positive correlation between the peroxidase glutation activity and estradiol (Massafra et al 2000).…”

Section: Discussionmentioning

confidence: 97%

Oxidative state of ewes with different number of parity during gestation and lactation

et al. 2017

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This study was conducted to assess the changes in some indicators of oxidative status during pregnancy and lactation in sheep of different parity. Dorset x Suffolk ewes were classified by number of parity: 1, 2 and ≥4. They were sampled before pregnancy and on the first, second, third, and fourth months, then on day 143 of pregnancy, as well as on day 5 after birth and after one month of lactation. Antioxidant capacity was found to have two reductions, the first during the second month of pregnancy and the second on day 5 of lactation. Susceptibility to lipid oxidation decreased with an increased number of parturitions. A reduction in lipid oxidation was observed on day 143 of gestation relative to the other samplings during gestation and lactation. Total glutathione peroxidase activity increased when the two reductions in antioxidant capacity took place. Ascorbic acid decreased during lactation and gestation; the lowest values were recorded in the third month of gestation. It is concluded that susceptibility to lipid oxidation decreases with the number of parturitions and that in ewes, during gestation and lactation, there is a mechanism that prevents lipid oxidation involving changes in antioxidant capacity, glutathione peroxidase and ascorbic acid.

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Section: Discussionmentioning

confidence: 97%

Oxidative state of ewes with different number of parity during gestation and lactation

et al. 2017

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“…We have previously shown that gonadotropins influence the antioxidant enzyme (AOE) activity in women with uterine hyperplasia simplex, hyperplasia complex, leiomyoma, and polyps [12,13,14,15]. Also, the extent of AOE and lipid hydroperoxides (LOOH) alterations varied with the examined gynecological diagnosis, including adenocarcinoma [16].…”

Section: Introductionmentioning

confidence: 99%

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

et al. 2019

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We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.

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“…Estradiol did not show significant correlation with CAT and GPx in male and female stroke patients and control group [39]. There was a significant positive correlation between estradiol level and SOD activity in the blood samples of women with endometrial polyps [40].…”

Section: Discussionmentioning

confidence: 73%

Impact of Estradiol on Circulating Markers of Oxidative Stress among Hypertensive Postmenopausal Women with Co-morbidities

Salini

Jeyanthi

2014

Int J Med Res Rev

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Background: Oxidative stress plays a key role in the pathogenesis of several age-associated diseases. The antioxidant properties of estradiol reduce oxidative stress related complications. Menopause is typified by a drop in endogenous estradiol that might subsequently affect women's wellbeing. Materials and Methods: 100 postmenopausal women were selected and classed into four groups. Estradiol (E2) and enzymatic antioxidant status were assessed among normotensive postmenopausal women (group-1), hypertensive postmenopausal women (group-2), hypertensive postmenopausal women with diabetes (group-3) and hypertensive postmenopausal women with renal insufficiency (group-4). Kruskal-Wallis test and correlation analysis were performed using SPSS16.0 statistical software. Results: Estradiol (E2), catalase (CAT), superoxide dismutase activity (SOD), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities were significantly decreased in hypertensive postmenopausal women with diabetes (group-3) and hypertensive postmenopausal women with renal insufficiency (group-4) compared normotensive postmenopausal women (group-1). Catalase, glutathione peroxidise and glutathione-S-transferase activities were significantly reduced in the three experimental groups compared to normotensive control. Estradiol exhibited significant positive correlations with catalase, superoxide dismutase and glutathione peroxidase. Conclusion: Elevated oxidative stress along with drop in estradiol levels in postmenopausal women seems to be aggravated by co-morbid conditions.

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Antioxidant enzymes in women with endometrial polyps: relation with sex hormones

Cited by 8 publications

References 39 publications

Oxidative state of ewes with different number of parity during gestation and lactation

Oxidative state of ewes with different number of parity during gestation and lactation

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

Impact of Estradiol on Circulating Markers of Oxidative Stress among Hypertensive Postmenopausal Women with Co-morbidities

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