Antioxidant enzymes and cancer

Khan, Md. Asaduzzaman; Tania, Mousumi; Zhang, Dianzheng; Chen, Hanchun

doi:10.1007/s11670-010-0087-7

Cited by 150 publications

(33 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13,14] Cancer patients show depressed adaptogenic functions in the body, including those of antioxidant protection. [15] We know about an important role of glutathione in antioxidant lung protection. [16] Some papers have shown that GGT-dependent prooxidant reactions are involved in inhibition of cancer cells proliferation.…”

Section: Introductionmentioning

confidence: 99%

The activity of metabolic enzymes in the saliva of lung cancer patients

Bel’skaya¹,

Kosenok²

2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

Background: So far, optimization problems for diagnostics and prognostication aids have been still relevant for lung cancer as a leader in the structure of cancers. Aims and Objectives: A search for regularities of changes in the saliva enzyme activity in patients with lung cancer. Materials and Methods: In the case-control study, 859 people divided into two groups took part: Primary (lung cancer, n = 286) and control (conventionally healthy, n = 573). All the participants went through a questionnaire survey, saliva biochemical counts, and a histological verification of their diagnosis. The enzyme activity was measured by spectrophotometry. Between group differences were measured with the nonparametric test. Results: In terms of lung cancer, we observe metabolic changes described with decreased de Ritis coefficient (P ˂ 0.001), as well as the increased activity of alanine aminotransferase (P = 0.022), alkaline phosphatase (P ˂ 0.001), gamma-glutamyl transpeptidase (P = 0.043), and α-amylase (P ˂ 0.001). We have identified specifics of the change in the enzyme activity depending on a histological type and a growth form of the tumor. There is the observable increased activity of α-amylase in the saliva in lung adenocarcinoma and neuroendocrine tumors (P ˂ 0.001). It has been found that irrespective of the histological type of lung cancer in a transition from central to peripheral forms of growth; there is the observable increased activity of all the enzymes. The significantly reduced activity of aspartate aminotransferase (by 51.4% for adenocarcinoma, P = 0.032; 48.8% for squamous cell lung cancer, P = 0.042) is a distinctive feature of central lung cancer. Conclusion: The nature of the change in the enzyme activity is ambiguous and to a greater degree depends on the tumor form of growth (central/peripheral lung cancer) than the histological type (adenocarcinoma/squamous cell lung cancer).

show abstract

Section: Introductionmentioning

confidence: 99%

The activity of metabolic enzymes in the saliva of lung cancer patients

Bel’skaya¹,

Kosenok²

2017

Natl J Physiol Pharm Pharmacol

View full text Add to dashboard Cite

show abstract

“…The role of MnSOD and its changes in gene expression during tumorigenicity in several cancer cell lines have been areas of intense investigation in the last decades; these studies have been reviewed in recent years [48,49,51]. In human bladder cancer, however, such information is quite limited.…”

Section: Discussionmentioning

confidence: 99%

Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer

Carta

Pavanello

Mastrangelo

et al. 2018

IJERPH

View full text Add to dashboard Cite

Introduction: Additional or better markers are needed to guide the clinical monitoring of patients with non-muscle-invasive bladder cancer (NMIBC). Aim: To investigate the influence of occupational exposures and genetic polymorphisms on recurrence and progression of NMIBC. Methods: The study includes 160 NMIBC patients. We collected on questionnaire information on demographic variables, lifetime smoking history, lifetime history of occupational exposure to aromatic amines and polycyclic aromatic hydrocarbons. Genetic polymorphism (glutathione S-transferase M1; T1; P1 (GSTM1; GSTT1; GSTP1); N-acetyltransferase 1; 2 (NAT1; NAT2); cytochrome P450 1B1 (CYP1B1); sulfotransferase 1A1 (SULT1A1); myeloperoxidase (MPO); catechol-O-methyltransferase (COMT); manganese superoxide dismutase (MnSOD); NAD(P)H:quinone oxidoreductase (NQO1); X-ray repair cross-complementing group 1; 3 (XRCC1; XRCC3) and xeroderma pigmentosum complementation group (XPD)) was assessed in peripheral blood lymphocytes. DNA adducts were evaluated by 32P-postlabeling. Predictors of recurrence (histological confirmation of a newly found bladder tumor) and progression (transition of tumor from low-grade to high-grade and/or increase in TNM stage) were identified by multivariate Cox proportional hazard regression with stepwise backward selection of independent variables. Hazard ratios (HR) with 95% confidence interval (95%CI) and two-tail probability of error (p-value) were estimated. Results: The risk of BC progression decreased with the homozygous genotype “ValVal” of both COMT and MnSOD (HR = 0.195; 95%CI = 0.060 to 0.623; p = 0.006). The results on BC recurrence were of borderline significance. No occupational exposure influenced recurrence or progression. Conclusion: Our results are supported by experimental evidence of a plausible mechanism between cause (ValVal genotype of both MnSOD and COMT) and effect (decreased progression of tumor in NMIBC patients). The genetic polymorphisms associated with better prognosis may be used in clinic to guide selection of treatment for patients initially diagnosed with NMIBC. However, external validation studies are required.

show abstract

“…The effects of curcumin on GST expression are complex and may involve competitive enzyme inhibition as well as indirect enzyme induction [25]. Genetic polymorphisms in GST and its altered expression and activity are associated with oxidative DNA damage with subsequent risk of cancer susceptibility [26]. The inducible response of curcumin action biomarker GST is sharper and lasted longer in case of the NCD in comparison to CUR.…”

Section: Discussionmentioning

confidence: 99%

Novel Anticancer Curcumin Derivative with Conserved Functional Groups

Aziz¹,

El-Asmar²,

Rezq³

et al. 2012

J Cancer Ther Res

View full text Add to dashboard Cite

Background: Curcumin, a polyphenol from turmeric, has potent anticancer properties in human cancer cell lines. Nevertheless, its multitargeting clinical application in cancer and other diseases is hampered by its poor systemic bioavailability. A novel curcumin derivative "NCD" was developed through covalent modification of the curcumin "CUR" molecule on sites remote from its natural functional groups.

show abstract

Antioxidant enzymes and cancer

Cited by 150 publications

References 47 publications

The activity of metabolic enzymes in the saliva of lung cancer patients

The activity of metabolic enzymes in the saliva of lung cancer patients

Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer

Novel Anticancer Curcumin Derivative with Conserved Functional Groups

Contact Info

Product

Resources

About