Antioxidant efficacy of black pepper (<i>Piper nigrum</i>L.) and piperine in rats with high fat diet induced oxidative stress

Vijayakumar, R.; Surya, Diksha; Nalini, Namasivayam

doi:10.1179/135100004225004742

Cited by 256 publications

(163 citation statements)

References 21 publications

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“…Antioxidants effectively prevent this kind of cellular damage. 32 The reduction of serum TC, LDL-C and the atherogenic index indicates that OM reduces intestinal absorption and secretion and also possesses in vivo antioxidant activity. However, Om.Cr did not show in vitro antioxidant activity in the DPPH free radical scavenging assay.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

et al. 2009

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The objective of this study was to investigate the possible mode(s) of action for the medicinal use of Orchis mascula (OM) (family Orchidaceae) in hypertension and dyslipidemia. In spontaneously hypertensive rats (SHRs), OM significantly (Po0.05) reduced systolic blood pressure to 174.2±9.63 vs. 203.4±7.13 mm Hg (mean±s.e.m.; n¼7-10) and improved endothelial dysfunction by increasing acetylcholine-induced relaxation. In normotensive anesthetized rats, the crude extract of OM (Om.Cr) at 10 and 30 mg kg À1 caused a dose-dependent attenuation of mean arterial pressure. OM also decreased serum triglycerides to 29.28 ± 6.99 vs. 93.84 ± 5.7 mg per 100 ml (Po0.001), low-density lipoprotein-cholesterol to 5.99 ± 1.27 vs. 21.9 ± 3.5 mg per 100 ml (Po0.05) and atherogenic index to 0.096±0.017 vs. 0.36±0.08 mg per 100 ml (Po0.05). OM significantly reduced lipid levels in tyloxapol and high fat diet-induced hyperlipidemia. In a second model, OM also reduced gain in body weight with a reduction in daily diet consumption. In isolated rabbit aorta, Om.Cr caused concentration-dependent relaxation of both phenylephrine and high K + (80 mM)-induced contractions and a rightward shift of the calcium concentration-response curves similar to the effect seen with verapamil. In conclusion, OM shows antihypertensive and endothelial-modulating effects mediated through multiple pathways that include direct vasodilation by calcium channel blockade and reduction of plasma lipids by inhibition of biosynthesis, absorption and secretion. This study rationalizes the medicinal use of OM in hypertension and dyslipidemia. However, further studies are required to identify the active constituents of this plant.

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Section: Discussionmentioning

confidence: 99%

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

et al. 2009

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“…In addition to its common utility as a gustatory enhancer, it has found many rather diverse applications ranging from brandy flavouring to its use as an insecticide (Budavari et al, 1989). It is also reported to have antioxidant activity yielding potentially beneficial results versus the damaging effects of a high-fat diet (Naidu & Thippeswamy, 2002;Vijayakumar et al, 2004) and is reported to exhibit antidiarrhoeal and gastroprotective properties in rodents (Bajad et al, 2001;Szolcsanyi & Bartho, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

McNamara

Randall

Gunthorpe

2005

British J Pharmacology

272

186

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1 We have characterised the effects of piperine, a pungent alkaloid found in black pepper, on the human vanilloid receptor TRPV1 using whole-cell patch-clamp electrophysiology. 2 Piperine produced a clear agonist activity at the human TRPV1 receptor yielding rapidly activating whole-cell currents that were antagonised by the competitive TRPV1 antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red. 3 The current-voltage relationship of piperine-activated currents showed pronounced outward rectification (2574-fold between À70 and þ 70 mV) and a reversal potential of 0.070.4 mV, which was indistinguishable from that of the prototypical TRPV1 agonist capsaicin. 4 Although piperine was a less potent agonist (EC 50 ¼ 37.971.9 mM) than capsaicin (EC 50 ¼ 0.2970.05 mM), it demonstrated a much greater efficacy (approximately two-fold) at TRPV1. 5 This difference in efficacy did not appear to be related to the proton-mediated regulation of the receptor since a similar degree of potentiation was observed for responses evoked by piperine (230720%, n ¼ 11) or capsaicin (284732%, n ¼ 8) upon acidification to pH 6.5. 6 The effects of piperine upon receptor desensitisation were also unable to explain this effect since piperine resulted in more pronounced macroscopic desensitisation (t 1/2 ¼ 9.970.7 s) than capsaicin (t 1/2 420 s) and also caused greater tachyphylaxis in response to repetitive agonist applications. 7 Overall, our data suggest that the effects of piperine at human TRPV1 are similar to those of capsaicin except for its propensity to induce greater receptor desensitisation and, rather remarkably, exhibit a greater efficacy than capsaicin itself. These results may provide insight into the TRPV1-mediated effects of piperine on gastrointestinal function.

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“…[55] P. longum has revealed hepatoprotective action [56] and balances enzymatic and non-enzymatic antioxidants levels by lessening oxidative stress which is the major contributor of diabetes. [57] Nabi et al have reported duel action of Piper longum by presenting antidiabetic (reducing blood glucose level) action as well as hepatoprotective (significantly reduced the level of triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol, very LDL -cholesterol, and serum enzymes) action. [29] Hence, it can be said that Pippali has a potential as an antidiabetic as well as also manage complicated factors associated with the disease.…”

Section: Indications Referencesmentioning

confidence: 99%

Untitled

Reddy

2017

IJGP

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Over the past three decades, the number of people with diabetes mellitus (DM) has doubled globally, making it one of the most important public health challenges to all nations. This has been stimulating the development of novel and potentially more effective therapeutic approaches to treat the disease. Even after the availability of a massive amount of hypoglycemic drugs in conventional system, herbals are gaining much attention because of its spectacular therapeutic potential and also help to sustain the healthy condition of the body. In this review article, a highly valuable drug Pippali (Piper longum) has been evaluated on the basis of its pharmacognostical, pharmacological, and therapeutical background. The plant possesses significant antidiabetic activity. The systemic dysfunction associated with DM can also be cured by Pippali. Plant through exhibiting synergistic action gives a valuable response in hepatic, digestive, cardiac, and respiratory disorders. The purpose of this review is to enlighten all the remedial aspects of P. longum with a special focus on its antidiabetic potential.

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Antioxidant efficacy of black pepper (Piper nigrumL.) and piperine in rats with high fat diet induced oxidative stress

Cited by 256 publications

References 21 publications

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

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