Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles

Hieda, Yuhzo; Anraku, Makoto; Choshi, Tominari; Tomida, Hisao; Fujioka, Haruto; Hatae, Noriyuki; Hori, Osamu; Hirose, Junzo; Hibino, Satoshi

doi:10.1016/j.bmcl.2014.05.050

Cited by 41 publications

(24 citation statements)

References 31 publications

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“…reported the protective effects of a monoterpene indole alkaloid, psychollatine, on the hydroxyl radicals, employing the hypoxanthine/xanthine oxidase assay. Several other studies reported the antioxidant potential of alkaloids isolated from different plant sources …”

Section: Resultsmentioning

confidence: 99%

Investigations on Antioxidant, Antiproliferative and COX‐2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.) Miq. Leaves

Chandel

Kumar

Sharma

et al. 2017

Chemistry & Biodiversity

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In the present study, an ayurvedic medicinal plant, Anthocephalus cadamba (Roxb.) Miq. commonly known as 'Kadamb' was explored for its potential against oxidative stress and cancer. The fractions namely AC-4 and ACALK (alkaloid rich fraction) were isolated from A. cadamba leaves by employing two different isolation methods and evaluated for their in vitro antioxidant and antiproliferative activity. The structure of the isolated AC-4 was characterized tentatively as dihydrocadambine by using various spectroscopic techniques such as ESI-QTOF-MS, H- and C-NMR, DEPT, COSY, HMQC, and HMBC. Results of various antioxidant assays viz. 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS cation radical, superoxide anion radical scavenging, and plasmid nicking assay demonstrated that both the fractions viz. AC-4 and ACALK possess ability to scavenge DPPH, ABTS radicals and effectively protected plasmid pBR322 DNA from damage caused by hydroxyl radicals. Further, when both fractions were evaluated for their potential to suppress growth of HeLa and COLO 205 cells, only ACALK fraction showed antiproliferative effects. ACALK exhibited GI of 205.98 and 99.54 μg/ml in HeLa and COLO 205 cell lines, respectively. Results of Hoechst staining in cervical carcinoma (HeLa) cells confirmed that ACALK induced cell death in HeLa cells via apoptotic mode. Both the fractions also inhibited COX-2 enzyme activity.

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Section: Resultsmentioning

confidence: 99%

Investigations on Antioxidant, Antiproliferative and COX‐2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.) Miq. Leaves

Chandel

Kumar

Sharma

et al. 2017

Chemistry & Biodiversity

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“…Terpenoids are important phytochemicals that have significant antioxidant and anti-inflammatory potentials [26,27]. Alkaloids have also been demonstrated to scavenge diphenyl-2-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, reduce cupric ions attributed to the ability of the pyrrole nitrogen to form an iminoquinone structure by donating either a hydrogen or electrons to the free radicals [28]. It has also been suggested that the alkaloids could also strengthen the antioxidation of other phytochemicals such as polyphenols [29].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract

Ndoni¹,

Ere²,

Okoko³

2017

Oxid Antioxid Med Sci

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Objective: Costus afer is a perennial monocot consumed as a remedy for various ailments. The present study investigates the effect of C. afer stem extract on ferrous/ascorbate-induced lipid peroxidation in rat brain, liver, and kidney homogenates. The inherent antioxidant and free radical scavenging potentials of the extract were also assessed using various in vitro models. Methods: Homogenates of isolated tissues were prepared, and lipid peroxidation was induced using the ferrous/ascorbate system and subsequently incubated with various concentrations of the extract. The ability of the methanolic extract to scavenge hydroxyl radicals, hydrogen peroxide and its ability to reduce ferric ions were investigated. The total antioxidant potential through the phosphomolybdate method was also measured. Results: The results revealed that C. afer stem extract reduced tissue lipid peroxidation induced by ferrous/ascorbate. The extract also possessed significant antioxidant/ free radical scavenging activity through the other in vitro models. In all cases, the effects were concentration dependent. Conclusion: The methanolic extract of C. afer stem possessed significant antioxidant potential ascribable to important phytochemicals and could protect cells/tissues from reactive oxygen species-induced damage. Thus, the plant has high pharmacological and ethnobotanical prospects.

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“…Antioxidants are regarded as drugs that can be used in the treatment of conditions such as inflammation, carcinogenesis, cardiovascular diseases . Although there was not any studies on the antioxidant capacity of thieno[ a ]dibenzothiophene derivatives, the antioxidant effects of thiophenes and benzothiophenes have been reported in many studies .…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and In vitro Evaluation of Thieno[a]dibenzothiophene Derivatives

et al. 2020

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A variety of highly substituted thieno[2,3‐a]dibenzothiophenes and thieno[3,2‐a]dibenzothiophenes are readily prepared via cascade electrophilic cyclization reaction. The reaction was tolerated a variety of compounds. In the present study, antimicrobial and antifungal activities were investigated for all synthesized molecules against A. niger ATCC 16404, C. albicans ATCC 10231, S. aureus ATCC 25923 and B. subtilis ATCC 6633, respectively.

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Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles

Cited by 41 publications

References 31 publications

Investigations on Antioxidant, Antiproliferative and COX‐2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.) Miq. Leaves

Investigations on Antioxidant, Antiproliferative and COX‐2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.) Miq. Leaves

Assessment of the in vitro anti-lipid peroxidative activity of Costus afer stem extract

Design, Synthesis, and In vitro Evaluation of Thieno[a]dibenzothiophene Derivatives

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