Antioxidant effect of royal jelly on immune status of hyperglycemic rats

Al-Kushi, Abdullah G.; Header, Eslam A.; ElSawy, Naser A.; Moustafa, Reham A.; Alfky, Nehal A. A.

doi:10.4103/pm.pm_87_18

Cited by 4 publications

(4 citation statements)

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“…It is a natural antibiotic and plays an efficient role in developing the larval stages in blood cells and maintains its ovulatory characteristics during the whole life span. Moreover, RJ has antioxidants with the potential of reducing the risk of cancer, high blood pressure, diabetes, and cardiovascular diseases [94,110,111]. RJ also affects the morphological characters, growth, learning, size, and shape variations in various creatures, such as honeybees, mice, and humans [112].…”

Section: Biological Activity Of Rjmentioning

confidence: 99%

“…Pharmaceutical studies elucidate that RJ has multiple activities that are attributable to their bioactive compounds, including proteins, peptides, lipids, phenolics, and flavonoid compounds. Recently, RJ has shown potential for use against cancer, diabetic, cardiovascular, and Alzheimer's disease (AD) in modern pharmaceutical research [77,102,110]. The pharmaceutical effects of RJ ( Figure 5) and its constituents in health-promotion through modulation of various biological activities are discussed below.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

“…RJ also has the potential to reduce the irregular status of 30 mM glucose conditions in human endothelial cells under diabetic situations [151]. The splenic tissue repair in diabetic rats by RJ via increasing antioxidant enzymes and reducing glucose levels [110]. Furthermore, RJ considerably improves the serum level of triglycerides, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein, cholesterol, and ApoA-1 in diabetic patients, thereby promoting the glycemic status, oxidative stress, and lipid profile [83].…”

Section: Anti-diabetic Effectmentioning

confidence: 99%

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New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

161

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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Section: Biological Activity Of Rjmentioning

confidence: 99%

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Section: Anti-diabetic Effectmentioning

confidence: 99%

See 1 more Smart Citation

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

161

134

View full text Add to dashboard Cite

show abstract

“…DISCUSSION AND CONCLUSION Traditional medicine has long employed bee products extensively.Intriguing bioactivities, such as antimicrobial[21][22], anti-inflammatory[23], and anticancer[24] properties, have been demonstrated for the components, water or ethanolic extrats, and izolated biologicaly active ingredients from these products. Along with treating some tumors, bee products have also been widely used to treat a number of immune-related disorders[25]. Numerous malignant cell lines, including those from the prostate, breast, lung, and liver malignancies, have shown evidence of in vitro cellular apoptosis being induced by bee products.…”

mentioning

confidence: 99%

Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells

Ayna

Darendelioğlu

2022

Türk Doğa Ve Fen Dergisi

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Due to their high toxicity to healthy body cells, chemotherapy drugs used to treat cancer pose a serious threat to the organism. Recent studies have encouraged the utilization of bee products to prevent and treat the cancer. The specific food for the queen honeybee larva (Apis mellifera), royal jelly (RJ) is a yellow, milky, cremy product of the bee which is stowed from the mandibular and hypopharyngeal glands of the worker honeybee. According to the reports, RJ may have cytotoxic effects in animal models. However, RJ's cytotoxic and antioxidant properties on PC-3 prostate cancer and MCF-7 breast cancer cell lines have yet to be thoroughly investigated at the cellular level. Therefore, the antioxidant and anti-proliferative activities of RJ in PC-3 prostate cancer cells and MCF-7 breast cancer cells were evaluated to investigate a chemopreventive strategy to increase cancer therapy efficacy. WST-1 assay was used to measure cell proliferation, and levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) were analyzed to look at antioxidant activities. According to the data of this research, RJ act as prooxidants in PC-3 and MCF-7 cancer cell lines by lessening cellular viability and raising ROS and LPO formation.

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The Protective Role of Royal Jelly against the Biochemical and Structural changes of Penile Corpora Cavernosa in Diabetic Rats

Alshali,

El-Aziz,

Aggad

et al. 2024

Preprint

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Diabetes mellitus (DM) is a leading cause of erectile dysfunction (ED). Understanding the structure of erectile tissue within the penile corpora cavernosa and their pathological changes in these tissues is essential for developing protective and therapeutic strategies. As the current diabetes management does not protect against ED, promising natural agents such as royal jelly (RJ), which has variable bioactive components that possess antioxidant, anti-inflammatory and antidiabetic properties are needed. This study aimed to investigate the effect of induced DM on the biochemical and structural components of the corpora cavernosa and to evaluate the protective effect of RJ on these parameters. Forty adult albino male rats were randomly divided into 4 groups: the control group, the RJ group: received oral RJ (100 mg/kg/day), the diabetic group: subjected to induction of DM by using Streptozotocin (60 mg/kg) intraperitoneally; and the diabetic and RJ groups: subjected to DM induction and received RJ. All rats were sacrificed after 60 days; blood was drawn to estimate differences in diabetes parameters, testosterone levels, oxidative/antioxidant markers and nitrous oxide (NO) concentrations. Additionally, penile tissues were fixed in formalin for histological and immunohistochemical studies. STZ-induced DM results in marked hyperglycemia, decreased insulin, testosterone, and NO levels; and oxidative/antioxidative imbalance. Histologically, corpora cavernosa showed a decrease in collagen fibers, elastic and smooth muscle fibers with a disturbed normal architecture. Treatment of diabetic rats with RJ markedly decreased these biochemical and structural alterations. In conclusion, RJ cotreatment is a promising practice for diabetes-induced corpora cavernosal damage possibly through its antihyperglycemic, antioxidant, and androgenic effects.

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Antioxidant effect of royal jelly on immune status of hyperglycemic rats

Cited by 4 publications

References 0 publications

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells

The Protective Role of Royal Jelly against the Biochemical and Structural changes of Penile Corpora Cavernosa in Diabetic Rats

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