Antioxidant effect of riboflavin in enzymic lipid peroxidation

Toyosaki, Toshiyuki

doi:10.1021/jf00022a001

Cited by 23 publications

(18 citation statements)

References 6 publications

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“…There is evidence for direct antioxidant effects of folate, B6 species, and riboflavin (25)(26)(27). We found that patients with high circulating vitamin concentrations, e.g., vitamin supplement users, and participants in WENBIT (compared to NORVIT) exhibited the same (and, in some cases, larger) relative differences in vitamin concentrations between smoking categories as patients with lower concentrations.…”

Section: Possible Mechanismsmentioning

confidence: 57%

Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins

et al. 2010

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Section: Possible Mechanismsmentioning

confidence: 57%

Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins

et al. 2010

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“…Riboflavin inhibits the formation of hydroperoxides (Huang et al, 2010). The mechanism may be that riboflavin can quench free radicals through its reversion from reduced form to oxidized form (Toyosaki, 1992).…”

Section: Discussionmentioning

confidence: 99%

Dietary riboflavin requirement of fingerlingChanna punctatus(Bloch) based on growth, conversion efficiencies, protein retention, liver riboflavin storage, RNA/DNA ratio and carcass composition

Zehra

Khan

2017

Aquacult Nutr

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A 16‐week experiment was conducted to determine the dietary riboflavin requirement of the fingerling Channa punctatus (6.7 ± 0.85 cm; 4.75 ± 0.72 g) by a feeding casein–gelatin‐based (450 g/kg crude protein; 18.39 kJ/g gross energy) purified diet containing graded levels of riboflavin (0, 2, 4, 6, 8, 10 and 12 mg/kg diet) to triplicate groups of fish near to satiation at 09:30 and 16:30 hr. Absolute weight gain (AWG), protein efficiency ratio (PER), specific growth rate (SGR, % per day), protein retention efficiency (PRE%) and RNA/DNA ratio were positively affected by increasing concentrations of dietary riboflavin to 6 mg riboflavin per kg diet. Feed conversion ratio (FCR) decreased up to 6 mg riboflavin per kg diet but did not decrease further with higher riboflavin supplementation. Hepatic thiobarbituric acid‐reactive substance (TBARS) concentration also supported the pattern of FCR, whereas superoxide dismutase and catalase activities increased with increasing concentrations of dietary riboflavin from 0 to 6 mg/kg. Liver riboflavin concentrations increased with increasing levels of riboflavin up to 8 mg/kg diet. Broken‐line regression analysis of AWG, PRE and liver riboflavin concentrations of fingerling C. punctatus with dietary riboflavin level indicated optimum growth and liver riboflavin saturation at 5.7, 6.1 and 7.7 mg riboflavin per kg diet, respectively.

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“…In vitro studies also indicated that riboflavin was shown to inhibit the formation of hydroperoxides (such as H 2 O 2 and ROOH) (Toyosaki and Mineshita 1988). The mechanism may be that riboflavin can quench free radicals through its reversion from reduced form to oxidized form (Toyosaki 1992).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary riboflavin levels on antioxidant defense of the juvenile grouper Epinephelus coioides

Huang

Liu

et al. 2008

Fish Physiol Biochem

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This study was conducted to evaluate the effects of dietary riboflavin on antioxidant defense in the juvenile grouper Epinephelus coioides. Graded levels of riboflavin (0.9, 1.6, 4.4, 6.7, 12.9 and 19.4 mg kg(-1) dry diet) were fed to grouper juveniles (mean weight: 14.90 +/- 0.46 g) for 12 weeks. Higher levels of liver thiobarbituric acid reactive substances (TBARS) content were observed in grouper fed low doses (0.9 and 1.6 mg kg(-1) diet) of riboflavin. Both liver glutathione reductase (GR) activity and its activation coefficient (GR-AC) poorly responded to riboflavin deficiency. In addition, other indices of the glutathione-dependent defense system, including the activities of glutathione peroxidase (GSH-PX) and glutathione-S-transferase (GST), and the content of glutathione (GSH), were also non-significantly affected by dietary riboflavin levels. However, the activities of liver superoxide dismutase (SOD) and catalase (CAT) were significantly lower in fish fed 0.9 mg kg(-1) diet, with a positive correlation between the different groups. In conclusion, the present study indicated that the juvenile grouper fed the riboflavin-unsupplemented diet was susceptible to lipid peroxidation (LPO), with lower SOD and CAT activities in the liver. However, the glutathione-dependent defense system of grouper was not affected by dietary riboflavin levels.

show abstract

Antioxidant effect of riboflavin in enzymic lipid peroxidation

Cited by 23 publications

References 6 publications

Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins

Long- and Short-term Effects of Tobacco Smoking on Circulating Concentrations of B Vitamins

Dietary riboflavin requirement of fingerlingChanna punctatus(Bloch) based on growth, conversion efficiencies, protein retention, liver riboflavin storage, RNA/DNA ratio and carcass composition

Effects of dietary riboflavin levels on antioxidant defense of the juvenile grouper Epinephelus coioides

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