Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats

Abstract

The effect of Monascus purpureus red mould rice (RMR) on modulation of lipid metabolism and oxidative stress was studied in hypercholesterolemic rats. Cholesterol feeding for 14 weeks caused a significant increase in the lipid peroxides and total thiols and antioxidant enzymes, viz. glutathione peroxidase (GPx), glutathione reductase (GRd), superoxide dismutase (SOD) and catalase (CAT) in serum and liver in comparison to the control group. However, supplementation of RMR to hypercholesterolemic rats at 8, 12 and 16% significantly increased the GRd, GPx, SOD and CAT activities in serum and liver tissues. Furthermore, RMR feeding significantly decreased total thiols and lipid peroxides and also increased other antioxidant molecules such as glutathione and ascorbic acid in high-cholesterol fed rats. The efficiency of RMR (16%) in modulating the antioxidant molecules and antioxidant enzymes is comparable to standard drug-lovastatin. Thus, this study suggests that the long-term administration of RMR may play an important role in suppressing oxidative stress and, thus, may be useful for the prevention and/or early treatment of hypercholesterolemia.

Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants

“…Therefore to maintain the physiological redox environment, the excess radicals are get scavenged by blood antioxidants [ 2 ]. Hyperlipidemia disrupts this redox balance and cause abnormal and uncontrolled release of free radicals resulting in accelerated atherogenic events developing a state of oxidative stress [ 3 ]. Endothelial cell membrane and unsaturated lipids including trans fatty acids is the main content of circulating low density lipoproteins (LDL) are the most vulnerable sites for free radical attack.…”

Antioxidant effect of amaranth flour or protein isolate incorporated in high‐fat diets fed to Wistar rats. Influence of dose and administration duration

“…A 1 g sample was homogenized with 10 ml of cold PBS [in ice, 6 min, 400 rpm, ULTRA-TURRAX T8.01 (IKA)]. After centrifugation (10,000× g, 10 min, 4°C), the supernatant was separated and stored at −80°C(Mohan-Kumari et al, 2011;Noeman et al, 2011). Lipid oxidation (TBARS), GSH content, SOD activity, and GPx activity were evaluated.…”

Analisis Kimia, Mikrobiologi Dan Organoleptik Margarin Yang Memanfaatkan Bubuk Angkak Sebagai Pewarna Alami

“…Komponen tersebut merupakan pigmen dan senyawa fenolik yang mempunyai aktivitas antioksidan yang tinggi. Menurut Kumari et al, (2011) Angkak mengandung beberapa antioksidan seperti asam dimerumik, tanin dan fenol (Mohan-Kumari et al, 2011).…”