Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice

Abstract

Polygonatum sibiricum polysaccharides (PSP), the extract of Polygonatum sibiricum, are demonstrated to exhibit a wide range of pharmacological activities. A recent study reported that PSP alleviated the aging of the kidney and meninges. However, the effect of PSP on heart aging remains unclear. The present study is aimed at investigating the protection of PSP on D-galactose- (D-gal-) induced heart aging. Results showed that irregularly arranged cardiac muscle fibers were observed in heart tissues of D-gal-treated mice, and the levels of cardiac troponin T (cTnT), creatine kinase (CK), p21, and p53 were increased after D-gal treatment. D-gal-induced heart aging and injury can be attenuated by oral administration of PSP. Moreover, PSP also decreased reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the level of superoxide dismutase (SOD) in the hearts of D-gal-treated mice. DNA damages and lipid peroxidation induced by oxidative stress were also inhibited by PSP as indicated by reduced levels of 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (4-HNE). Collectively, PSP attenuated D-gal-induced heart aging via inhibiting oxidative stress, suggesting that PSP might serve as a potential effective Chinese herbal active constituent for antiaging therapy.

Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice

“…T-AOC is an important nonenzymatic antioxidant, and its decreased levels are associated with a reduced resistance of the body’s antioxidant defense system against free radicals [ 38 ]. T-SOD is a free radical scavenging enzyme in vivo key enzyme that converts superoxide anion radicals into hydrogen peroxide and oxygen to prevent oxidative stress damage [ 39 ]. Studies have shown that dietary fiber contains the presence of some active substances (e.g., polyphenols) [ 40 ], which, as key components of dietary fiber, can exert antioxidant effects by complexing metal ions, increasing antioxidant enzyme activity, scavenging free radicals, and regulating the expression of signaling pathways, such as Nrf2/ARE [ 41 , 42 ], which is more consistent with the results obtained in this study.…”

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

“…In the last three years, Polygonatum sibiricum polysaccharides (PSP) are demonstrated to exhibit a wide range of pharmacological activity [ 21 ], such as osteogenic activity [ 22 ], anti-diabetes [ 23 ], immunological activity [ 24 ], and especially antioxidant activity, which makes them suitable for application in functional foods and therapeutic agents. PSP demonstrated strong antioxidant properties, which could attenuate D-gal-induced heart aging [ 25 ] and protect the mice livers against ethanol-induced oxidative damage via inhibiting oxidative stress [ 26 ]. However, no study has been reported using PSP as a decorator to functionalize SeNPs.…”

A Review of Polygonatum Mill. Genus: Its Taxonomy, Chemical Constituents, and Pharmacological Effect Due to Processing Changes

“…D-gal treatment decreased reactive oxygen species (ROS) and MDA and enhanced SOD levels in the hearts of mice. By reducing the levels of 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal, PSP also prevented oxidative stress-induced DNA damage and lipid peroxidation (4-HNE) [ 67 ]. Regarding other species, extracts of P. alte-lobatum (EPA) dose-dependently reduced exercise-induced urea nitrogen and malondialdehyde and enhanced hepatic glycogen, an essential workout fuel [ 68 ].…”