Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia–reperfusion injury

Dokuyucu, Recep; Karateke, Atilla; Gökçe, Haşan; Kurt, Raziye Keskin; Özcan, Oğuzhan; Öztürk, Savaş; Tas, Zeynel Abidin; Karateke, Faruk; Duru, Mehmet Emin

doi:10.1016/j.ejogrb.2014.10.018

Cited by 31 publications

(27 citation statements)

References 31 publications

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“…Erdosteine [ N -(carboxymethylthioacetyl)-homocysteine thiolactone] is a mucoactive agent with antioxidant activity that involves a thiol group [15]. Erdosteine has been reported to protect against hepatic, renal, retinal, and cardiotoxicity [16].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model

Karateke¹,

Dokuyucu²,

Doğan

et al. 2018

Med Princ Pract

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Objective: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder. In the present study, we investigated the therapeutic effects of erdosteine in letrozole-induced PCOS in rats. Methods: Thirty-two Wistar albino female rats were grouped as control group (C), PCOS group (PCOS), PCOS-metformin group (PCOS+MET), and PCOS-erdosteine group (PCOS+Erd). PCOS was induced by administering letrozole; such rats presented with sex hormone disorder, abnormal estrous cycles determined by daily vaginal smear, large cystic follicles, and increasing fasting insulin levels. After induction of PCOS, metformin (500 mg/kg/day) and erdosteine (100 mg/kg/day) were given orally to the treatment groups for 30 days. Serum concentrations of glucose, total cholesterol, low- and high-density lipoprotein, triglyceride, as well as the total oxidant and antioxidant status, oxidative stress index, circulating estrone (E1), estradiol (E2), testosterone, and androstenedione were evaluated. The ovaries were graded histologically. Results: Weights of ovarian tissues (p < 0.05) and the number of atretic follicles (p < 0.001) and cystic follicles (p < 0.01) decreased in the PCOS+Erd group; the corpus luteum number was significantly higher in the PCOS+Erd group (p < 0.01) as compared with the PCOS group. Lipid parameters (total-C, LDL-C, and TG), E1 (estrone), E1/E2 ratio, testosterone, and androstenedione significantly decreased, while HDL-C and E2 (estradiol) significantly increased in the PCOS+Erd group as compared with the PCOS group. Moreover glucose, insulin, and HOMA-IR were reduced with treatment of erdosteine (p > 0.05, p < 0.001, and p < 0.001, respectively). Conclusion: It is suggested that erdosteine may be used in the treatment of PCOS as an alternative to metformin. It appears that our findings might be supported by clinical and molecular studies.

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Section: Introductionmentioning

confidence: 99%

Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model

Karateke¹,

Dokuyucu²,

Doğan

et al. 2018

Med Princ Pract

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“…Administration of Tempol at a dose of 50 mg/kg was more effective than at a dose of 30 mg/kg, and this difference was statistically significant. OSI values were significantly lower in Group IV and Group V compared with Group III (Dokuyucu et al 2014) demonstrated that TOS and OSI increased and TAS decreased in ischemia and I/R groups compared with the sham group. Group III compared with Group I.…”

Section: Discussionmentioning

confidence: 94%

“…Ischemia (i.e. insufficient blood flow and lack of oxygen) not only decreases ATP production but also increases lactic acid production and accumulates lipid peroxidase in tissues (Dokuyucu et al 2014). After reperfusion of the ovarian tissues, reactive oxygen species such as hydroxyl radical (OH), superoxide anion (O 2 -.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of tempol in an experimental ovarian ischemia–reperfusion injury model in female Wistar albino rats

Pınar

Karapınar

Özcan

et al. 2017

Can. J. Physiol. Pharmacol.

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“…In a previous study, 150 mg/kg erdosteine was found to be effective in preventing local tissue injury following testicular torsion (18). In another study, Yurdakul et al reported that levels of MDA and xanthine oxidase were decreased by erdosteine treatment (19).…”

Section: Discussionmentioning

confidence: 98%

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

Özer¹,

Demirtaş²,

Çomu³

et al. 2018

Turk J Med Sci

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Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods:Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control' , n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion' , n = 6), and an ischemia/ reperfusion group with erdosteine at 150 mg kg -1 , intraperitoneally (group 'ischemia/reperfusion -erdosteine' , n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion -erdosteine groups revealed similar results (P = 0.051). The values of the ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion -erdosteine groups (P < 0.0001 and P = 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/ reperfusion compared to the control and ischemia/reperfusion -erdosteine groups (P < 0.05). Conclusion:We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversing undesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies with larger volumes.

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Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia–reperfusion injury

Cited by 31 publications

References 31 publications

Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model

Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model

Protective effects of tempol in an experimental ovarian ischemia–reperfusion injury model in female Wistar albino rats

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

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