Antioxidant Effect in Red Ginger (Zingiber Officinale Var. Rubrum) Extract during the COVID-19 Pandemic

Sholikhati, Anisa; Farikhah, Lailatul; Ridwanto, Muhammad

doi:10.26911/icphmedicine.fp.08.2021.09

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…In contrast, in the T1, T2, and T3 treatments, the IC50 value was less than 50 ppm, which means that the antioxidant activity in this treatment was potent. The IC50 value of red ginger oleoresin nanoemulsion in the T1, T2, and T3 treatments was smaller than the red ginger extract in Sholikhati et al [29], namely 41.27 ppm. That is, the antioxidant activity of red ginger in nanoemulsion form is stronger when compared to red ginger extract.…”

Section: Antioxidant Activity Of Red Ginger Oleoresin Nanoemulsionmentioning

confidence: 60%

Effect of Ultrasonication on Some Chemical Properties of Red Ginger (Zingiber officinale var. rubrum) Oleoresin Nanoemulsion Bioactive Compounds

Wirawati,

Pratiwi,

Nirmagustina

2023

Trends Sci

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Nanotechnology has developed in various industrial fields. This encourages innovation in the use of additives such as antioxidants, dyes, flavors, and other active ingredients that can be modified in the form of nanoemulsions. Red ginger contains oleoresin, which has thick properties to form a paste. These properties make oleoresin difficult to mix with food, disperse, hydrophobic and susceptible to the effects of heat and light. One solution to overcome this problem is to convert oleoresin into a nanoemulsion so that it has high solubility, is stable, good bioavailability, and improves sensory properties. One technique for making nanoemulsions is ultrasonication. The high-intensity ultrasonication effect can cause the movement of the oil phase into the liquid phase in the form of droplets, thereby increasing the pressure in the liquid and resulting in the breakdown of the oil droplets into smaller sizes. The purpose of this research was to determine the effect of ultrasonication on some chemical properties of the red ginger oleoresin nanoemulsion bioactive compounds, which includes antioxidant activity, total phenol, gingerol content, and droplet microstructure. The study used a completely randomized design with four treatments based on sonication time. Data from the test results were analyzed using analysis of variance (ANOVA) and Tukey's advanced test. Based on the results of the analysis, it was found that ultrasonication had effect on the red ginger oleoresin nanoemulsion biactive compounds. The best treatment is 90 min of sonication. The antioxidant activity (IC50) was 11.45±3.48 ppm, the total phenolic content was 3342.74±283.00 mg GAE/g, and the gingerol content was 0.33 %. The nanoemulsion droplet microstructure complies with the standard; that is, the particles are in the form of small spheres, like balls, and there are no visible holes or cracks on the surface of the particles. HIGHLIGHTS Red ginger contains higher oleoresin than other types of ginger Oleoresin is in the form of a viscous paste, so it is hydrophobic Application of nanoemulsion to oleoresin can increase solubility and bioavailability One of the methods for making nanoemulsions is using ultrasonication The novelty in this research is the manufacture of red ginger oleoresin nanoemulsion using the ultrasonication method to increase the content of bioactive compounds such as antioxidant activity, total phenolic content, and gingerol GRAPHICAL ABSTRACT

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Section: Antioxidant Activity Of Red Ginger Oleoresin Nanoemulsionmentioning

confidence: 60%

Effect of Ultrasonication on Some Chemical Properties of Red Ginger (Zingiber officinale var. rubrum) Oleoresin Nanoemulsion Bioactive Compounds

Wirawati,

Pratiwi,

Nirmagustina

2023

Trends Sci

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“…Rubrum has long been used in Indonesian herbal medicine. Many studies have confirmed the anti-inflammatory (Fikri et al, 2016), antioxidant (Sholikhati et al, 2022), antiemetic (Hartati et al, 2022), antibacterial (Assegaf et al, 2020), and antidiabetic (Eliza Arman, 2016) properties of red ginger.…”

Section: Introductionmentioning

confidence: 95%

IN SILICO STUDY: SECONDARY METABOLITES FROM RED GINGER RHIZOME (Zingiber Officinale Var. Rubrum) AS POTENTIAL INHIBITORS OF3CLpro AND PLpro OF SARS-CoV-2

Suherman,

Maulidya

2023

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The COVID-19 outbreak prompted the development of novel drugs to treat the disease. Targeting of virus proteins has attracted great interest in the discovery of COVID-19 drugs. 3CLpro and PLpro are promising targets because of their important role in viral replication. Hence, various efforts have been made to find specific therapeutics for COVID-19, including those derived from plants as anti-Covid-19. Red ginger rhizome (Zingiber officinale var. rubrum) contains secondary metabolites that are known for their health benefits. This in silico study aimed to determine the potency of red ginger rhizome as PLpro and 3CLpro of SARS-CoV-2 inhibitor which may be applied to treat COVID-19. This research was conducted using molecular docking and molecular dynamics simulations. The molecular docking simulation of red ginger compounds in complex with SARS-CoV-2 PLpro showed that 27 compounds have a binding free energy (?G) lower than that of the reference ligand. On the other hand, none of the complexes between red ginger compounds and 3CLpro had a lower binding free energy than the reference ligand. Visualization of interaction features at the PLpro of SARS-CoV-2’s active site shows that secondary metabolites dominantly interact with hydrogen bonds. The ar-curcumene and PLpro complex of SARS-CoV-2 appears very stable and has the lowest flexibility compared to HBA as a native ligand and molnupiravir as a reference ligand based on RMSD and RMSF plot analysis using molecular dynamic simulation...

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“…Gingerol and 6-gingerol are the main components of oleoresin that are sensitive to heat, light, and oxygen. Gingerol and shogaol are the sources of ginger's spicy and pungent flavor (Sholikhati et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The quality of tinuktuk in the frozen temperature storage

Damanik,

Riris,

Susanti

et al. 2024

J. Pendidik. Kim

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Tinuktuk is considered nutritious and able to boost immunity. A local product based on natural resources and spices in Indonesia. The different concentrations of the main ingredients used in the production of tinuktuk produce good quality and nutrition for safe, healthy, and nutritious consumption. So far, there is no optimum composition of tinuktuk and also quality analysis during the storage period in the frozen temperature of tinuktuk, so this research is necessary. In this research, the roasting method is used for the drying process of making tinuktuk. The roasting process is one of the isothermal drying processes. The purpose of this study was to determine the quality characteristics of tinuktuk during storage at -10°C for 56 days which is analyzed every 7 days. Tinuktuk characteristic parameters include pH, moisture content, ash content, and microbial analysis. The results of the research that have been carried out are 30%: 70% and 40%: 60%, which have similarities with the results of the analysis of tinuktuk that has been marketed, namely the 30%: 70% ratio, wherein the 30%: 70% ratio the pH analysis decreases steadily from 6.3 to 5.9. Ash content analysis resulted in a stable decrease from 7% to 5%. Microbial analysis with ALT testing resulted in stable data during storage at 2.5 x 102 colonies/g. Antioxidant analysis of 30%:70% ratio resulted in antioxidant IC50 data of 93, 4 ppm to 183.6 ppm.

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Antioxidant Effect in Red Ginger (Zingiber Officinale Var. Rubrum) Extract during the COVID-19 Pandemic

Cited by 3 publications

References 4 publications

Effect of Ultrasonication on Some Chemical Properties of Red Ginger (Zingiber officinale var. rubrum) Oleoresin Nanoemulsion Bioactive Compounds

Effect of Ultrasonication on Some Chemical Properties of Red Ginger (Zingiber officinale var. rubrum) Oleoresin Nanoemulsion Bioactive Compounds

IN SILICO STUDY: SECONDARY METABOLITES FROM RED GINGER RHIZOME (Zingiber Officinale Var. Rubrum) AS POTENTIAL INHIBITORS OF3CLpro AND PLpro OF SARS-CoV-2

The quality of tinuktuk in the frozen temperature storage

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