Antioxidant defense capacity in scleroderma patients

Sfrenț-Cornățeanu, Roxana; Mihai, Carina; Stoian, Irina; Lixandru, Daniela; Bara, Constantin; Moldoveanu, E

doi:10.1515/cclm.2008.132

Cited by 17 publications

(26 citation statements)

References 31 publications

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“…The TAS value remained low, even when corrected as a function of plasma albumin and uric acid, which is defined as RAS. The RAS values were 0.37 ± 0.09 mmol/L Trolox equivalents, which is low compared to those reported by Miller and Sfrent-Cornateanu et al (0.45 and 0.92 mmol/L Trolox equivalents, respectively) (33,50). A number of studies have thus shown that TAS decreases during aging and that there is a gender-related difference, with higher values for men than for women, which is in agreement with our results (data not show).…”

Section: Variables Total (N = 57) Placebo (N = 12) Rt (N = 17) As (N contrasting

confidence: 62%

Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Bobeuf

Labonté

Dionne

et al. 2011

The Journal of nutrition, health and aging

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This study was aimed to examine the effect of vitamin C/E intake alone or combined with resistance training on antioxidant/pro-oxidant status, muscle strength and body composition in an elderly population. Fifty-seven men and women with a mean age of 65.6 ± 3.8 years were recruited and randomized in a double-blind fashion into four groups: control-placebo; resistance training (RT); vitamins C/E supplementation (AS); AS+RT. Oxidative stress status and metabolic and lipid profiles were determined at baseline and after six months. Fat-free mass and fat mass measured by DXA were similar at baseline for all groups. At six month, there was a significant difference among the groups as a function of vitamin E supplementation. Moreover, although there was no effect on pro-oxidative parameters, a significant effect on body composition was noted, but no difference was noted on strength gain. The combination of RT+AS had a positive effect on the plasma antioxidant profile but not on the pro-oxidant status.

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Section: Variables Total (N = 57) Placebo (N = 12) Rt (N = 17) As (N contrasting

confidence: 62%

Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Bobeuf

Labonté

Dionne

et al. 2011

The Journal of nutrition, health and aging

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“…,15,23,32 The plasma components responsible for the antioxidant status are albumin, uric acid, ascorbic acid, a-tocopherol, b-carotene, bilirubin, glutathione, cysteine, dihydrolipoate and ubiquinol. TAC is modulated by the free radical load, metal concentration and dietary intake of antioxidants and results from the balance between oxidant species and plasma antioxidants.…”

mentioning

confidence: 99%

Oxidative stress in the pathogenesis of systemic scleroderma: An overview

Vona¹,

Giovannetti

Gambardella³

et al. 2018

J Cellular Molecular Medi

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Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability and death as the result of end‐stage organ failure. Two clinical subsets of the SSc are accepted: limited cutaneous SSc (lc‐SSc) and diffuse cutaneous SSc (dc‐SSc). At present, the aetiology and pathogenesis of SSc remain obscure, and consequently, disease outcome is unpredictable. Numerous studies suggest that reactive oxidizing species (ROS) play an important role in the pathogenesis of scleroderma. Over the years, several reports have supported this hypothesis for both lc‐SSc and dc‐SSc, although the specific role of oxidative stress in the pathogenesis of vascular injury and fibrosis remains to be clarified. The aim of the present review was to report and comment the recent findings regarding the involvement and role of oxidative stress in SSc pathogenesis. Biomarkers proving the link between ROS and the main pathological features of SSc have been summarized.

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“…Regarding clinical correlation, there was no influence of age, disease duration, skin score, lung involvement (DLco), or inflammation (ESR) on TAP level. [22]. In both reports, there was no difference observed about TAP levels between dSSc and lSSc patients.…”

Section: Discussionmentioning

confidence: 79%

“…TAP measurement in plasma from SSc patients has been reported with conflicting result [21,22]. In the first paper reported by Italian group, TAP level was not decreased against odds, moreover, it was even higher than in healthy control.…”

Section: Discussionmentioning

confidence: 99%

Increasing levels of serum antioxidant status, total antioxidant power, in systemic sclerosis

et al. 2011

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Sciences Running title: Total antioxidant power levels in SScKey words: systemic sclerosis, oxidative stress, total antioxidant power, biomarker Methods: Serum TAP levels were examined in 49 patients with SSc by colorimetric microplate assay. The assay measures the total abilities for reducing Cu++ into Cu+.Clinical evaluation including medical history, physical examination, and laboratory tests were conducted for all SSc patients.Results: Serum TAP levels were significantly elevated in SSc patients compared to normal controls (p<0.01). When values higher than the mean + 2SD of the control serum samples were considered to be elevated, TAP levels were elevated in 24% of total SSc patients with 26% of diffuse cutaneous SSc patients and 23% of limited cutaneous SSc patients. Serum TAP levels were correlated positively with C-reacting protein (r=0.35, p<0.05). However, no other significant correlation was observed between serum TAP levels and clinical features in SSc patients. Conclusion:These results suggested that oxidative stress is enhanced in SSc patients and serum TAP levels increase as an indicator of the global response to oxidative stress.

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Antioxidant defense capacity in scleroderma patients

Cited by 17 publications

References 31 publications

Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population

Oxidative stress in the pathogenesis of systemic scleroderma: An overview

Increasing levels of serum antioxidant status, total antioxidant power, in systemic sclerosis

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