Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis

Alves, Monique Gabriela Chagas Faustino; Dore, Celina Maria Pinto Guerra; Castro, Allisson Jhonatan Gomes; Nascimento, Marília S.; Cruz, Ana Katarina Menezes da; Soriano, Eliane Marinho; Benevídes, Norma Maria Barros; Leite, Edda Lisboa

doi:10.1007/s10811-011-9763-3

Cited by 35 publications

(4 citation statements)

References 61 publications

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“…The results showed that the JASX presented important concentration-dependent chelating capacity at 1.0 mg.mL −1 (78.52%), while EDTA ferrous chelating ability was 99.50% at the same concentration. The ferrous ionchelating power enregistrated for JASX was higher than that reported by Alves et al [40] using sulfated polysaccharides from Hypnea musciformis, which had 8.0% ferrous ionchelating ability at 5.0 mg.mL −1 . The result of 65.13% (at 0.9 mg.mL −1 ) was higher than the result of 62.46% (at 2.0 mg.mL −1 ) found by Alencar et al [41] for sulfated polysaccharides produced from Gracilaria caudata.…”

Section: Ferrous Ion-chelating Activitycontrasting

confidence: 60%

Structural Characterization and Rheological and Antioxidant Properties of Novel Polysaccharide from Calcareous Red Seaweed

et al. 2022

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A novel sulfated xylogalactan (JASX) was extracted and purified from the rhodophyceae Jania adhaerens. JASX was characterized by chromatography (GC/MS-EI and SEC/MALLS) and spectroscopy (ATR-FTIR and 1H/13C NMR) techniques. Results showed that JASX was constituted by repeating units of (→3)-β-d-Galp-(1,4)-3,6-α-l-AnGalp-(1→)n and (→3)-β-d-Galp-(1,4)-α-l-Galp-(1→)n substituted on O-2 and O-3 of the α-(1,4)-l-Galp units by methoxy and/or sulfate groups but also on O-6 of the β-(1,3)-d-Galp mainly by β-xylosyl side chains and less by methoxy and/or sulfate groups. The Mw, Mn, Đ, [η] and C* of JASX were respectively 600 and 160 kDa, 3.7, 102 mL.g−1 and 7.0 g.L−1. JASX exhibited pseudoplastic behavior influenced by temperature and monovalent salts and highly correlated to the power-law model and the Arrhenius relationship. JASX presented thixotropic characteristics, a gel-like viscoelastic behavior and a great viscoelasticity character. JASX showed important antioxidant activities, outlining its potential as a natural additive to produce functional foods.

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Section: Ferrous Ion-chelating Activitycontrasting

confidence: 60%

Structural Characterization and Rheological and Antioxidant Properties of Novel Polysaccharide from Calcareous Red Seaweed

et al. 2022

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“…ι-Carrageenan, a marine sulfated galactan, has been widely applied in the food industry as a food ingredient. , In the functional food field, ι-carrageenan exhibits various biological activities, such as antiviral, antioxidant, and antitumor activities. , However, the application of carrageenan was limited due to its indigestible β-glycosidic bond . Therefore, biodegradation may be one of the applicable ways to solve this problem.…”

Section: Introductionmentioning

confidence: 99%

Novel ι-Carrageenan Tetrasaccharide Alleviates Liver Lipid Accumulation via the Bile Acid–FXR–SHP/PXR Pathway to Regulate Cholesterol Conversion and Fatty Acid Metabolism in Insulin-Resistant Mice

Tian

Cai

et al. 2021

J. Agric. Food Chem.

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ι-Carrageenan tetrasaccharide (ιCTs), a novel oligosaccharide, was hydrolyzed from ι-carrageenan with targeting marine tool-enzyme Cgi82A. Previously, we have found ιCTs exhibited a hypoglycemic effect, whether it could regulate lipid metabolism remains unknown. In this study, the insulin-resistant mice induced by high-fat−high-sucrose diet were orally administrated with ιCTs (30 mg/kg•bw) for 20 weeks. The results showed that the contents of triglyceride and cholesterol in both serum and liver were reduced by ιCTs, and their excretion in feces were promoted, suggesting lipid accumulation was inhibited. Intriguingly, the overall levels of bile acid in serum, liver, and feces were all raised by ιCTs. Given that bile acids are the essential signal factors for regulating lipid metabolism via the farnesoid-X-receptor (FXR), we conducted serum bile acid profile analysis and found that the levels of high-affinity agonists deoxycholic acid and lithocholic acid were decreased in the ιCTs group, showing that ιCTs failed to activate FXR. Western blot analysis showed that ιCTs downregulated hepatic FXR and small heterodimer partner (SHP) expression and increased downstream CYP7A1 expression via regulating the FXR−SHP signal to accelerate liver cholesterol conversion. Meanwhile, ιCTs decreased the expression of PXR and SREBP1c and elevated the expression of PPARα and CPT1α via regulating the FXR-PXR-SREBP1c/PPARα signal to inhibit fatty acid synthesis and promote fatty acid β-oxidation. To the best of our knowledge, this study for the first time reported that ιCTs alleviated liver lipid accumulation via the bile acid−FXR−SHP/PXR signal to regulate cholesterol conversion and fatty acid metabolism, which highlighted a new idea for ameliorating insulin resistance.

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“…Hypnea musciformis is a widely-distributed red seaweed known to produce large amounts of -carrageenan (Alves et al, 2012). It has been commercially exploited in Brazil (McHugh, 2003), and is considered a potentially profitable species due to its high yields of -carrageenan, fast growth rate and tolerance to different environmental conditions (Vázquez-Delfin, Robledo, & Freile-Pelegrin, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…It has been commercially exploited in Brazil (McHugh, 2003), and is considered a potentially profitable species due to its high yields of -carrageenan, fast growth rate and tolerance to different environmental conditions (Vázquez-Delfin, Robledo, & Freile-Pelegrin, 2013). Although several works have previously studied the sulfated galactans from this seaweed, they usually focused on single aspects, such as their structure (Bi, Arman, Hassan, & Iqbal, 2006;Greer, Shomer, Goldstein, & Yaphe, 1984;Hamilton & Carrol, 1962;Knutsen et al, 1995), rheological properties (Andrade, Azero, Luciano, & Gonc ¸ alves, 2000;Bi, Hassan, Arman, Iqbal, & Mahmood, 2007;Mahmood et al, 2007) or biological activities as elicitors of plant defense mechanisms (Arman, 2011;Arman & Ul Qader, 2012;Bi, Arman, Ali, & Iqbal, 2009;Bi & Iqbal, 1999, 2000, 2005Bi, Iqbal, Ali, Aman, & Hassan, 2008;Bi, Iqbal, Arman, Ali, & Hassan, 2011), antioxidant (Alves et al, 2012), antiinflamatory (De Brito et al, 2013Rodrigues, de Araújo, de Paula, Vanderlei, et al, 2011) or cytotoxic (Alves et al, 2012;Rodrigues, de Araújo, de Paula, Lima, et al, 2011). In most of these works, the non-purified extracted polysaccharide (considered to be -carrageenan) was used.…”

Section: Introductionmentioning

confidence: 99%

Chemical and rheological characterization of the carrageenans from Hypnea musciformis (Wulfen) Lamoroux

Navarro

Fissore

Rojas

et al. 2014

Carbohydrate Polymers

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Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis

Cited by 35 publications

References 61 publications

Structural Characterization and Rheological and Antioxidant Properties of Novel Polysaccharide from Calcareous Red Seaweed

Structural Characterization and Rheological and Antioxidant Properties of Novel Polysaccharide from Calcareous Red Seaweed

Novel ι-Carrageenan Tetrasaccharide Alleviates Liver Lipid Accumulation via the Bile Acid–FXR–SHP/PXR Pathway to Regulate Cholesterol Conversion and Fatty Acid Metabolism in Insulin-Resistant Mice

Chemical and rheological characterization of the carrageenans from Hypnea musciformis (Wulfen) Lamoroux

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