Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies

Pace, Nelson; Desrosiers, Tania A.; Carmichael, Suzan L.; Shaw, Gary M.; Olshan, Andrew F.; Siega‐Riz, Anna Maria

doi:10.1111/ppe.12403

Cited by 10 publications

(13 citation statements)

References 30 publications

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“…As has been done previously in birth defects research, to appropriately control for confounding, 14 we selected covariates a priori using subject matter expertise and causal-directed acyclic graphs. 15 The covariates included in adjusted models were maternal age, education, race and/or ethnicity (white non-Hispanic, African American non-Hispanic, Hispanic), marital status (yes or no), and Medicaid status (yes or no).…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic Factors and Survival of Infants With Congenital Heart Defects

Pace

Oster

Forestieri³

et al. 2018

Pediatrics

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Section: Discussionmentioning

confidence: 99%

Sociodemographic Factors and Survival of Infants With Congenital Heart Defects

Pace

Oster

Forestieri³

et al. 2018

Pediatrics

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“…It is well established that maternal dietary intake during pregnancy is important for the developing foetus, and subsequent child outcomes [ 47 , 48 ]. Dietary pattern analysis during pregnancy has mainly focused on pregnancy and child outcomes rather than on associations with maternal nutrient status.…”

Section: Discussionmentioning

confidence: 99%

Dietary Determinants of Polyunsaturated Fatty Acid (PUFA) Status in a High Fish-Eating Cohort during Pregnancy

et al. 2018

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Polyunsaturated fatty acids (PUFA) are essential for neurodevelopment and the developing foetus depends on an optimal maternal status. Fish is a rich source of PUFA. The current study investigated dietary patterns, and associations with PUFA status in a high-fish consuming cohort of pregnant women in the Seychelles. At 28 weeks’ gestation, pregnant women provided a blood sample, from which serum total PUFA concentrations were measured, A Food Frequency Questionnaire (FFQ) and Fish Use Questionnaire (FUQ) were also completed. Principal component analysis (PCA) of dietary information identified four patterns. Regression analyses found dietary pattern 2, containing foods traditionally eaten in the Seychelles e.g., fish, fruit and vegetables was positively associated with serum docosahexaenoic acid (DHA) (β = 0.134; CI = 0.001, 0.022), and serum total n-3 PUFA (β = 0.139; CI = 0.001, 0.023) concentrations. Dietary pattern 1, high in processed foods, snacks, white meat and eggs, was not significantly associated with any of the serum PUFA concentrations. The FUQ indicated that fatty fish was associated with EPA status (β = 0.180; CI = 0.001, 0.005) in high consumers. The second dietary pattern, consisting of higher consumption of fish and fruit, was positively associated with n-3 PUFA status during pregnancy.

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“…In our examination, foreign‐born NH Black mothers were also more educated (12+ years) compared to U.S.‐born mothers (which was not observed in the other acculturation analysis indicated above). A recent NBDPS analysis found that mothers with a higher antioxidant intake in their diet (based on an estimation of prepregnancy antioxidant consumption of total fruits and vegetables collected in the NBDPS food frequency questionnaire) was associated with a reduced risk of both transverse (OR 0.74, 95% CI 0.57, 0.96) and longitudinal limb defects (OR 0.82, 95% CI 0.59, 1.13) (Pace et al, ). Although a range of factors have been correlated with a healthier diet—including higher levels of education (Xie, Gilliland, Li, & Rockett, ), household income (Xie et al, ), and lower BMI (Ohlund, Hernell, Hörnell, Stenlund, & Lind, )—acculturation to the U.S.‐lifestyle among Hispanic and NH Black immigrants has been associated with more unhealthy diets (e.g., increased intake of salty snacks/calorie‐rich foods and fewer fruits and vegetables) (Batis, Hernandez‐Barrera, Barquera, Rivera, & Popkin, ; Desilets, Rivard, Shatenstein, & Delisle, ).…”

Section: Discussionmentioning

confidence: 99%

Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study

Hoyt

Ramadhani

et al. 2020

Birth Defects Research

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Background There are noted birth defects prevalence differences between race/ethnicity groups. For instance, non‐Hispanic (NH) Black mothers are more likely to have an infant with encephalocele, although less likely to have an infant with anotia/microtia compared to NH Whites. When stratifying by nativity and years lived within the United States, additional variations become apparent. Methods Data from the National Birth Defects Prevention Study were used to calculate descriptive statistics and estimate crude/adjusted odds ratios (aORs) and 95% confidence intervals (95%CIs) among NH Blacks with one of 30 major defects and non‐malformed controls. Total case/controls were as follows: U.S.‐ (2,773/1101); Foreign‐ (343/151); African‐born (161/64). Study participants were also examined by number of years lived in the U.S. (≤5 vs. 6+ years). Results Compared to U.S.‐born, foreign‐born NH Black controls tended to be older, had more years of education, and were more likely to have a higher household income. They also had fewer previous livebirths and were less likely to be obese. In the adjusted analyses, two defect groups were significantly attenuated: limb deficiencies, aORs/95%CIs = (0.44 [0.20–0.97]) and septal defects (0.69 [0.48–0.99]). After stratifying by years lived in the United States, the risk for hydrocephaly (2.43 [1.03–5.74]) became apparent among those having lived 6+ years in the United States. When restricting to African‐born mothers, none of the findings were statistically significant. Conclusions Foreign‐born NH Blacks were at a reduced risk for a few selected defects. Results were consistent after restricting to African‐born mothers and did not change considerably when stratifying by years lived in the United States.

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Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies

Abstract: Dietary intake of antioxidants was associated with reduced odds of limb deficiencies. These findings add further evidence for women's periconceptional diet reducing occurrence of some birth defects.

Cited by 10 publications

References 30 publications

Sociodemographic Factors and Survival of Infants With Congenital Heart Defects

Sociodemographic Factors and Survival of Infants With Congenital Heart Defects

Dietary Determinants of Polyunsaturated Fatty Acid (PUFA) Status in a High Fish-Eating Cohort during Pregnancy

Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study

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