Antioxidant compounds of Kielmeyera coriacea Mart. with α-amylase, lipase and advanced glycation end-product inhibitory activities

Justino, Allisson Benatti; Santana, Eder Cley; Queiroz, Julia Silveira; Silva, Heitor Cappato Guerra; Júnior, Joed Pires de Lima; Saraiva, André Lopes; Martins, Mário Machado; Morais, Sérgio Antônio Lemos de; Oliveira, Alberto de; Goulart, Luiz Ricardo; Aquino, Francisco José Tôrres de; Espíndola, Foued Salmen

doi:10.1016/j.jpba.2021.114387

Cited by 5 publications

(5 citation statements)

References 62 publications

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“…[21] Flavonoids are a class of specialized metabolites abundant in the Miconia genus, [3] constituting 48 % of the compounds isolated from the genus. Some molecules of this class were annotated as present in M. ibaguensis samples, namely: ( 14), (15), and (17), proposed as quercetinÀ hexoside (t R = 7.22 min; m/z 463.0899), quercetinÀ pentoside (t R = 7.43 min; m/z 433.0783) and quercetinÀ rhamnoside (t R = 7.69 min; m/z 447.0952), respectively. Regarding the fragmentation proposal, quercetin derivatives have in common the fragment ions m/z 300 and m/z 301, which correspond to the homolytic and heterolytic cleavage of the molecule.…”

Section: Annotation Of Specialized Metabolites Of M Ibaguensismentioning

confidence: 99%

“…These compounds help mitigate oxidative damage by scavenging free radicals, potentially alleviating diabetic symptoms and complications. [15][16][17] This study aims to contribute to the natural product chemistry field by investigating the chemical composition of Miconia ibaguensis leaves, which has not been done before. The biological potential of these leaves will be evaluated through antifungal, antibacterial, antidiabetic, and antioxidant assays.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, oxidative stress is implicated in diabetes progression, and phenolic compounds, especially flavonoids, are well‐recognized for their antioxidant properties. These compounds help mitigate oxidative damage by scavenging free radicals, potentially alleviating diabetic symptoms and complications [15–17] …”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

Sehnem,

Silva,

da C. Silva

et al. 2024

Chemistry & Biodiversity

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The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95 – 3.90 µg mL‐1) and potent antioxidant activity in the DPPH (1.74 ± 0.07 µg mL‐1), FRAP (654.01 ± 42.09 μmol ETrolox/gsample), and ORAC (3698.88 ± 37.28 μmol ETrolox/gsample) methods. The EE displayed inhibition against the α‐amylase enzyme (8.42 ± 0.05 µg mL‐1). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (–)‐HPLC‐ESI‐MS/MS analysis, were found to contribute to the species' biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.

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Section: Annotation Of Specialized Metabolites Of M Ibaguensismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

Sehnem,

Silva,

da C. Silva

et al. 2024

Chemistry & Biodiversity

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“…Antioxidant activity [80] Kielmeyera coriacea Protocatechuic acid, procyanidins A, B, and C and epicatechin Antioxidant and antiglycation activity, and LPL inhibition. [81].…”

Section: Guazuma Ulmifoliamentioning

confidence: 99%

“…The study conducted with Kielmeyera coriacea confirmed, in addition to antioxidant and antiglycation effects, the inhibitory effect on LPL, as well as other enzymes related to carbohydrate metabolism in vitro. The compounds found, including protocatechuic acid, epicatechin, and procyanidins A, B, and C, are likely responsible for the antioxidant, hyperglycemic, and hyperlipidemic effects of the plant [81].…”

Section: Antilipidemic Effects Of Cerrado Plants Through Enzymatic In...mentioning

confidence: 99%

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Monteiro-Alfredo,

Macedo,

de Picoli Souza

et al. 2023

IJMS

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Brazil has several important biomes holding impressive fauna and flora biodiversity. Cerrado being one of the richest ones and a significant area in the search for new plant-based products, such as foods, cosmetics, and medicines. The therapeutic potential of Cerrado plants has been described by several studies associating ethnopharmacological knowledge with phytochemical compounds and therapeutic effects. Based on this wide range of options, the Brazilian population has been using these medicinal plants (MP) for centuries for the treatment of various health conditions. Among these, we highlight metabolic diseases, namely obesity and its metabolic alterations from metabolic syndrome to later stages such as type 2 diabetes (T2D). Several studies have shown that adipose tissue (AT) dysfunction leads to proinflammatory cytokine secretion and impaired free fatty acid (FFA) oxidation and oxidative status, creating the basis for insulin resistance and glucose dysmetabolism. In this scenario, the great Brazilian biodiversity and a wide variety of phytochemical compounds make it an important candidate for the identification of pharmacological strategies for the treatment of these conditions. This review aimed to analyze and summarize the current literature on plants from the Brazilian Cerrado that have therapeutic activity against obesity and its metabolic conditions, reducing inflammation and oxidative stress.

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Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities of α-amylase and α-glucosidase

Justino

Silva

Pimentel

et al. 2022

Journal of Ethnopharmacology

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Antioxidant compounds of Kielmeyera coriacea Mart. with α-amylase, lipase and advanced glycation end-product inhibitory activities

Cited by 5 publications

References 62 publications

Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities of α-amylase and α-glucosidase

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