Antioxidant characteristics and antibacterial activity of native woody species from Catamarca, Argentina

Lorenzo, María Emilia; Casero, Carina Noelia; Gómez, Patricia Elizabeth; Segovia, Adrián Federico; Figueroa, Lara Carolina; Quiroga, Alejandro; Werning, María Laura; Wunderlin, Daniel Alberto; Baroni, María Verónica

doi:10.1080/14786419.2020.1839461

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…The FRAP value of CIEO was 1,502 μmol/L, 5.8 folds higher than that of CID at the equivalent concentration ( Figure 7 ). Several research highlights a robust positive correlation between the antioxidant activity of a substance and its antibacterial properties ( Martelli and Giacomini, 2018 ; Li et al, 2022 ; Lorenzo et al, 2022 ). The underlying mechanism suggests that the substance exerts antibacterial effects through its anti-free radical activity ( Lorenzo et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Several research highlights a robust positive correlation between the antioxidant activity of a substance and its antibacterial properties ( Martelli and Giacomini, 2018 ; Li et al, 2022 ; Lorenzo et al, 2022 ). The underlying mechanism suggests that the substance exerts antibacterial effects through its anti-free radical activity ( Lorenzo et al, 2022 ). Our results indicated that CIEO and CID displayed potent antioxidant activity ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

Shu,

Ge,

et al. 2024

Front. Pharmacol.

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Background: Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial mechanisms, especially the in vivo antibacterial mechanisms, remain elusive.Methods: In this study, we utilized the in vivo assessment system of Caenorhabditis elegans (C. elegans) to investigate the effects and mechanisms of high dose (100 mg/L) and low dose (10 mg/L) CIEO and CID in inhibiting Pseudomonas aeruginosa (P. aeruginosa). In addition, we also examined the in vitro antibacterial abilities of CIEO and CID against other common pathogens including P. aeruginosa and 4 other strains.Results: Our research revealed that both high (100 mg/L) and low doses (10 mg/L) of CIEO and CID treatment significantly alleviated the reduction in locomotion behavior, lifespan, and accumulation of P. aeruginosa in C. elegans infected with the bacteria. During P. aeruginosa infection, the transcriptional expression of antimicrobial peptide-related genes (lys-1 and lys-8) in C. elegans was upregulated with low-dose CIEO and CID treatment, while this trend was suppressed at high doses. Further investigation suggested that the PMK-1 mediated p38 signaling pathway may be involved in the regulation of CIEO and CID during nematode defense against P. aeruginosa infection. Furthermore, in vitro experimental results also revealed that CIEO and CID exhibit good antibacterial effects, which may be associated with their antioxidant properties.Conclusion: Our results indicated that low-dose CIEO and CID treatment could activate the p38 signaling pathway in C. elegans, thereby regulating antimicrobial peptides, and achieving antimicrobial effects. Meanwhile, high doses of CIEO and CID might directly participate in the internal antimicrobial processes of C. elegans. Our study provides research basis for the antibacterial properties of CIEO and CID both in vivo and in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

Shu,

Ge,

et al. 2024

Front. Pharmacol.

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“…In another study, the antioxidant activity of L. divaricata and L. cuneifolia collected in the province of Catamarca, Argentina, was corroborated by different methods such as the ferric reducing antioxidant power (FRAP), the Trolox equivalent antioxidant capacity (TEAC) and the 2,2-diphenyl-1picrylhydrazyl scavenger activity (DPPH) in vitro assays. These assays demonstrated that L. cuneifolia extracts had the highest antioxidant activity, followed by L. divaricata (Lorenzo et al, 2020).…”

Section: Antioxidant Effectsmentioning

confidence: 96%

Larrea divaricataa native Argentine plant with potential activity against SARS-CoV-2?

Alonso¹,

Marrassini²,

Martin³

et al. 2023

BLACPMA

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Larrea divaricataCav. is an autochthonous South American plant popularly used in inflammatory and infectious diseases with reported anti-inflammatory, immunomodulatory, antimicrobial and antioxidant activities. Covid-19 is an infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can cause pneumonia and even death in about 5% of the cases. The objective of the article was to demonstrate, through a literature review, that L. divaricatahas sufficient attributes to be assayed against SARS-CoV-2. For this, the chemical composition, reported activities and docking studies were taken into account. This review demonstrated that the plant extracts are capable of inhibiting the proliferation of fungi, bacteria and viruses and that they exert anti-inflammatory and immunomodulatory actions in different "in vitro" and "in vivo" models. These results suggest that the plant is a good candidate to be studied for the prevention and/or treatment of SARS -CoV-2.

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Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. on a melanoma cell line

Martino

Arcos

Peralta

et al. 2021

Natural Product Research

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Most of the deaths from skin cancer are caused by melanoma, a malignancy in which STAT3 plays a crucial role. The inhibition of STAT3 is considered a potential target to induce cell death, tumor regression and metastasis inhibition. The objective of this work was to evaluate the activity of the aqueous extract of Larrea divaricata (Aq), a fraction rich in polyphenols (EA),and the isolated compound quercetin-3-methyl ether (Q3ME) on B16F10 melanoma cells. The effects of Aq, EA and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3. The phytochemical composition of the extracts was determined by High Performance Liquid Chromatography. Aq, EA and Q3ME presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late apoptosis induction (EC 50 EA= ≤0.1 µg/ml; Aq= 316±30 µg/ml; Q3ME= <0.1 µg/ml). L. divaricata could be considered for the development of adjuvant phytotherapies in melanoma treatment.

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Antioxidant characteristics and antibacterial activity of native woody species from Catamarca, Argentina

Cited by 3 publications

References 16 publications

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

Larrea divaricataa native Argentine plant with potential activity against SARS-CoV-2?

Antiproliferative activity of aqueous and polyphenol-rich extracts of Larrea divaricata Cav. on a melanoma cell line

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