Antioxidant Capacity of Rigenase®, a Specific Aqueous Extract of Triticum vulgare

Antonucci, Immacolata; Fiorentino, Gabriella; Contursi, Patrizia; Minale, Massimiliano; Riccio, Rodolfo; Riccio, Salvatore; Limauro, Danila

doi:10.3390/antiox7050067

Cited by 17 publications

(26 citation statements)

References 19 publications

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“…An increase of actin polymerization has been linked to an increase in cell migration on wound edge and an improvement of wound contraction. By increasing the level of polymerized actin in fibroblasts, TVE could regulate the proliferative and remodeling phases of wound healing, accelerating the ability of fibro-blasts to repair the damage [9]. In 2018, Sanguigno, et al demonstrated that TVE also exerts anti-inflammatory properties since it reduces the release of the well-known agents triggering the inflammatory process, such as IL-6, TNFα, prostaglandin E2 and nitric oxide in LPS-stimulated BV2 microglial cells and in primary rat microglia, thus exerting an anti-inflammatory activity and favoring the transition from the inflammatory to regenerative process [12].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Verification of the Activity and Tolerability of Fitostimoline Vaginal Pessaries in Women with Hysterectomy: Randomized, Perspective, Monoscentric Study

2022

Gynecol Obstet Open Acc

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Objective: To evaluate the activity of Fitostimoline ® pessaries in comparison to the standard of care in the treatment of women with hysterectomy. Methods: An observational, randomized, perspective study performed on 60 women where 30 women were treated with Fitostimoline ® pessaries for 12 days after surgery and 30 women were treated with the standard of care. A first follow-up visit was performed at 12 +/-3 days and a final follow-up visit was performed at 40 +/-3 days. Results: At the first control, 45% of patients in the Fitostimoline ® group reported no evidence of vaginal bleeding after surgery; instead, 41% in the control group reported such result. At the final visit, 79% patients reported no evidence of vaginal bleeding in the Fitostimoline ® group, while 63% in the control group. The medial duration of minor vaginal bleeding in the Fitostimoline ® group was 11.8 days, whilst for discrete vaginal bleeding the medial duration was 4 days. In the control group instead it was 12 days, whilst for discrete vaginal bleeding the medial duration was 8 days. Conclusion: The use of Fitostimoline ® ovules after hysterectomy is effective in reducing the quantity of vaginal bleeding, regardless the menopausal status, surgical approach and type of indication to surgery.

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Section: Discussionmentioning

confidence: 99%

“…Vaginal cuff dehiscence usually occurs in the first weeks after surgery but can be delayed up to several years (especially in postmenopausal women). Vaginal cuff dehiscence often presents with postcoital bleeding, other vaginal spotting, or watery vaginal discharge [9].…”

Section: Introductionmentioning

confidence: 99%

Clinical Verification of the Activity and Tolerability of Fitostimoline Vaginal Pessaries in Women with Hysterectomy: Randomized, Perspective, Monoscentric Study

2022

Gynecol Obstet Open Acc

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“…Rigenase ® , a specific patented Triticum vulgare extract, exhibits antioxidant capacity by tissue-repairing activity and moisturizing action [ 18 ]; thus, it is used in the formulation of different medical devices—under the brand name Fitostimoline ® —with properties of accelerating tissue repair, improving the restoration of the epidermal barrier, and stimulating lipid synthesis [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial Activity Evaluation of a Novel Fitostimoline® Plus Spray Formulation

Falciglia

Palladino

Schiavo

2021

International Journal of Microbiology

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Wound contaminants are the main cause of healing delay and infection in both chronic and acute wounds; for this reason, the microbial infection management in wound healing is one of the most important components for an effective standard of care. The wound contaminants are most likely to originate from the environment and from the surrounding skin lesion, and to date, the most frequent bacteria isolated are Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In order to counteract and control these contaminants, the standard care includes topical antiseptic agents. The most commonly used include iodine-releasing agents (e.g., povidone-iodine), hydrogen peroxide, and polyhexanide. This study aims to investigate the in vitro antibacterial activity of a novel topical spray (Fitostimoline® Plus spray) based on 0.1% polyhexanide and Rigenase® against S. aureus, P. aeruginosa, K. pneumoniae, and the combination of S. aureus and K. pneumoniae. The in vitro antimicrobial activity of Fitostimoline® Plus spray was evaluated by the agar disk diffusion assay, quantitative suspension test, and quantitative carrier test, demonstrating that Fitostimoline® Plus spray is able to kill 99.9% bacteria. These results support the microbiological characterization of Fitostimoline® Plus spray confirming the antibacterial activity of polyhexanide (PHMB).

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“…as recently demonstrated, Damor TVE has a regenerating [13,14], antinflammatory [15] and anti-MMP9 activity [16], and antioxidant activity [17], which play a crucial role in the treatment of VVA. Furthermore, these recent studies suggest that Damor TVE is at least as efficacious as hyaluronic acid in favoring tissue re-epithelization and in contrasting inflammation.…”

Section: Introductionmentioning

confidence: 96%

Treatment of Vaginal Atrophy with the Aqueous Extract of Triticum vulgare: Comparison between Different Pharmaceutical Forms

2020

ARCH Women Health Care

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first-line treatment of VVA is a continuous sexual relationship, using non-hormonal lubricant over the counter vaginal [6]. The systemic and local estrogen administration is recommended for the treatment of VVA in postmenopausal women [7]. Although hormone therapy may alleviate the short and long term complications of menopause, such as hot flashes, night sweats, and VVA, it may increase the risk of breast and endometrial cancer [8]. Because of the adverse effects of estrogen therapy, some women prefer not to use this method for alleviating VVA, and they tend to use non-hormonal medication for this matter [9]. In this regard, it is noteworthy the evidence that a local treatment based on hyaluronic acid is more effective than hormonal therapy in improving VVA symptoms [10]. More recently, it has been showed that the aqueous extract of Triticum vulgare (TVE) in cream [11] and pessaries [12] formulation could reduce sign and symptoms of VVA in postmenopausal women. TVE containing mainly poly/ oligosaccharides' components has been extensively used in different pharmaceutical forms. The Damor Farmaceutici TVE, because of its global patent based on its production process, has unique characteristics that lead to its application in VVA treatment. In fact,

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Antioxidant Capacity of Rigenase®, a Specific Aqueous Extract of Triticum vulgare

Cited by 17 publications

References 19 publications

Clinical Verification of the Activity and Tolerability of Fitostimoline Vaginal Pessaries in Women with Hysterectomy: Randomized, Perspective, Monoscentric Study

Clinical Verification of the Activity and Tolerability of Fitostimoline Vaginal Pessaries in Women with Hysterectomy: Randomized, Perspective, Monoscentric Study

In Vitro Antimicrobial Activity Evaluation of a Novel Fitostimoline® Plus Spray Formulation

Treatment of Vaginal Atrophy with the Aqueous Extract of Triticum vulgare: Comparison between Different Pharmaceutical Forms

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