Antioxidant capacity of major royal jelly proteins of honeybee (Apis mellifera) royal jelly

Park, Min Ji; Kim, Bo Yeon; Deng, Yulin; Park, Hee Geun; Choi, Yong Soo; Lee, Kwang-Sik; Jin, Byung Rae

doi:10.1016/j.aspen.2020.03.007

Cited by 32 publications

(33 citation statements)

References 32 publications

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“…Both research teams affirmed that the antioxidant capacity of wax extracts is higher than that of (some) honey. In Table 5 also royal jelly and bee venom antioxidant properties are considered [ 20 , 29 , 161 , 162 , 163 , 164 , 165 , 166 ].…”

Section: Beeswaxmentioning

confidence: 99%

“…Table 5 summarizes the results of the most recent studies on the antioxidant properties of royal jelly and its derivatives. Using a DPPH radical-scavenging assay, Park et al [ 29 ] confirmed the antioxidant capacity of MRJPs 1–7 of A. mellifera at levels ranging between approximately 30 and 80% of residual radical. Pavel et al [ 162 ] quantified TPC and AOA in local (Romanian) and commercial royal jelly (10% in distilled water).…”

Section: Royal Jellymentioning

confidence: 99%

“…Different studies have been carried out to determine in vitro the AOA of bee products using biological (cellular) systems. The more recent ones are summarized in Table 6 [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 , 34 , 47 , 74 , 118 , 142 , 161 , 165 , 180 ]. Cell lines of different types and origins have, in the main, been used for this purpose in all bee products.…”

Section: In Vitro Determination Of Aoamentioning

confidence: 99%

“…In vitro and in vivo studies are seldom used to quantify the AOA of bee products, with a wide variability in tests and results, which we will outline below. The antioxidant properties of bee products have been applied to biological systems in vitro and in vivo, e.g., on cell lines [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], blood cells [ 30 , 31 , 32 , 33 , 34 ], or in different types of diseases in animal models and humans [ 3 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity in Bee Products: A Review

2021

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Bee products have been used since ancient times both for their nutritional value and for a broad spectrum of therapeutic purposes. They are deemed to be a potential source of natural antioxidants that can counteract the effects of oxidative stress underlying the pathogenesis of many diseases. In view of the growing interest in using bioactive substances from natural sources to promote health and reduce the risk of developing certain illnesses, this review aims to update the current state of knowledge on the antioxidant capacity of bee products such as honey, pollen, propolis, beeswax, royal jelly and bee venom, and on the analytical methods used. The complex, variable composition of these products and the multitude of analytical methods used to study their antioxidant activities are responsible for the wide range of results reported by a plethora of available studies. This suggests the need to establish standardized methods to more efficiently evaluate the intrinsic antioxidant characteristics of these products and make the data obtained more comparable.

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Section: Beeswaxmentioning

confidence: 99%

Section: Royal Jellymentioning

confidence: 99%

Section: In Vitro Determination Of Aoamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity in Bee Products: A Review

2021

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“…It is used to improve human health due to its remarkable antimicrobial and antioxidant properties. It is made up of various bioactive substances such as water (50-60%), proteins (18%), carbohydrates (15%), lipids (3-6%), vitamins, free amino acids and mineral salts (1,5%) (Aslan 2015;Ozsahin et al 2019;Sharif and Darsareh 2019;Park et al 2020;Aslan et al 2020a;Demir et al 2020). Royal jelly is known to have antitumor, antioxidative, antidiabetic, antiallergic, antibacterial, antiin ammatory and antihypertensive effects.…”

Section: Introductionmentioning

confidence: 99%

The inducing of caspase and bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Aslan

Can

Gök

et al. 2021

Preprint

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In this study, 42 Wistar albino female rats (n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control Group: Standard diet; (ii) RJ (royal jelly) Group: Standard diet + royal jelly; (iii) F50 Group: Standard diet + 50 mg/kg fluoride; (iv): F100 Group: Standard diet + 100 mg/kg fluoride; (v) F50 + RJ Group: Standard diet + 50 mg/kg fluoride + royal jelly; (iv): F100 + RJ Group: Standard diet + 100 mg/kg fluoride + royal jelly. After the 8-week study period, the rats were decapitated and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, Tnf-α, IL1-α and Bcl-2 proteins in muscle tissue were determined by Western Blotting method. Histopathological analyzes were also performed on the muscle tissue. MDA, GSH, and CAT analyzes were determined by spectrophotometric analysis. According to our findings, Bcl-2, Tnf-α and IL1-α protein expression were increased in damage groups compared to control and royal jelly groups, Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. There was an increase in MDA level in damage groups compared to the control and royal jelly groups, CAT and GSH levels decreased in damage groups. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects against fluoride damage.

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The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Aslan

Can

Gök

et al. 2021

Environ Sci Pollut Res

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Graphical abstract In this study, 42 Wistar albino male rats ( n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control group: Standard diet; (ii) RJ (royal jelly) group: Standard diet + royal jelly; (iii) F50 group: Standard diet + 50 mg/kg fluoride; (iv): F100 group: Standard diet + 100 mg/kg fluoride; (v) F50+RJ group: Standard diet + 50 mg/kg fluoride + royal jelly; (vi): F100+RJ group: Standard diet + 100 mg/kg fluoride + royal jelly. After 8 weeks, the rats were decapitated, and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, tumor necrosis factor-α (TNF-α), interleukin 1 alpha (IL1-α) and Bcl-2 proteins in muscle tissue were determined by western blotting method. Histopathological analyses were also performed on the muscle tissue. Malondialdehyde (MDA), glutathione (GSH) and catalase (CAT) analyses were determined by a spectrophotometer. According to the obtained results, Bcl-2, TNF-α and IL1-α protein expression was increased in damage groups compared to the control and royal jelly groups, while Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. MDA level increased in damage groups compared to the control and royal jelly groups, while CAT and GSH levels increased with royal jelly application in royal jelly-given group in comparison to the flouride-exposed group. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects on muscle tissue against fluoride damage.

show abstract

Antioxidant capacity of major royal jelly proteins of honeybee (Apis mellifera) royal jelly

Cited by 32 publications

References 32 publications

Antioxidant Activity in Bee Products: A Review

Antioxidant Activity in Bee Products: A Review

The inducing of caspase and bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

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