Antioxidant capacity of lipid- and water-soluble antioxidants in dogs with subclinical myxomatous mitral valve degeneration anaesthetised with propofol or sevoflurane

Tomsič, Katerina; Svete, Alenka Nemec; Nemec, Ana; Petrič, Aleksandra Domanjko; Pirman, Tatjana; Rezar, Vida; Vovk, Tomaž; Seliškar, Alenka

doi:10.1186/s12917-020-02529-7

Cited by 4 publications

(5 citation statements)

References 52 publications

(60 reference statements)

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“…Glutathione peroxidase activity remained unchanged in both groups ( 32 ). These results are in general agreement with clinical studies investigating oxidative stress in dogs with early-stage MMVD during propofol and sevoflurane anesthesia ( 9 , 44 ).…”

Section: Inhalational Anestheticssupporting

confidence: 91%

“…Tomsič et al ( 9 , 44 ) examined the effects of propofol on oxidative stress in dogs with early-stage myxomatous mitral valve degeneration (MMVD) undergoing periodontal treatment. In one study, the authors compared the effects of TIVA with propofol to anesthesia induced with propofol and maintained with sevoflurane on vitamin E, SOD, GPX, and lipid peroxidation marker malondialdehyde (MDA) ( 9 ).…”

Section: Intravenous Anestheticsmentioning

confidence: 99%

“…This could be attributed to the antioxidant properties of propofol. The authors concluded that propofol may be more suitable than sevoflurane for anesthesia of dogs with early-stage MMVD in terms of antioxidant capacity ( 44 ).…”

Section: Intravenous Anestheticsmentioning

confidence: 99%

“…Studies on the effects of anesthesia on oxidative stress in humans (3,4,(30)(31)(32)(33) and dogs (9,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) are based on the determination of changes in antioxidant (and oxidative) capacity, activities of antioxidant enzymes, and markers of oxidative damage to DNA, proteins, and lipids.…”

Section: Oxidative Stress Reactive Oxygen Species and Antioxidantsmentioning

confidence: 99%

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A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Tomsič

Svete

2022

Front. Vet. Sci.

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General anesthesia increases the production of reactive oxygen species (ROS), which can exacerbate or increase oxidative stress and thus affect the prognosis of surgical procedures. Oxidative stress has been implicated in the development of cardiovascular, dermatologic, oncologic, and other diseases in dogs, as well as ischemia and reperfusion injury. Some anesthetics, such as halogenated anesthetics, have been shown to stimulate the production of ROS, while others, such as propofol, have antioxidant properties. However, the antioxidant effects of these anesthetics may not be sufficient to counteract oxidative damage at the doses used clinically. Nevertheless, the effects of anesthetics should be considered to minimize oxidative damage during anesthesia in dogs to improve the outcome of procedures requiring general anesthesia. This mini-review addresses the current knowledge on oxidative stress during inhalational and intravenous anesthesia in dogs. There is still a lack of information on the management of anesthesia in dogs with respect to oxidative stress. Further research, including comprehensive clinical studies is needed to better understand oxidative injury mechanisms and improve perioperative protocols during anesthesia in dogs.

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Section: Inhalational Anestheticssupporting

confidence: 91%

Section: Intravenous Anestheticsmentioning

confidence: 99%

Section: Intravenous Anestheticsmentioning

confidence: 99%

Section: Oxidative Stress Reactive Oxygen Species and Antioxidantsmentioning

confidence: 99%

See 2 more Smart Citations

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Tomsič

Svete

2022

Front. Vet. Sci.

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“…Plasma ACL and ACW concentrations were measured as previously described ( 39 ) using a PHOTOCHEM analyzer and the reagent kits provided (Analytik Jena, Jena, Germany). Results are expressed in nmol equivalents of ascorbic acid in mL of sample for ACW and in nmol equivalents of Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) in mL of sample for ACL.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1

Tomsič,

Domanjko Petrič,

Nemec

et al. 2023

Front. Vet. Sci.

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Myxomatous mitral valve degeneration (MMVD) is the most common naturally occurring heart disease in dogs. There is a lack of data on antioxidant status and oxidative damage in dogs with MMVD stage B1 according to the American College of Veterinary Internal Medicine (ACVIM B1). The aim of this study was to investigate antioxidant status (plasma vitamin E, lipid-standardized vitamin E (LS-VitE), antioxidant capacity of lipid-(ACL) and water-soluble antioxidants, whole blood glutathione peroxidase and erythrocyte superoxide dismutase), and lipid peroxidation [malondialdehyde (MDA)] in dogs with MMVD ACVIM B1. Serum cholesterol and triglyceride concentrations were measured to calculate LS-VitE. Fourteen dogs with MMVD ACVIM B1 and 12 control dogs were included in the study. Dogs with MMVD had significantly higher vitamin E, ACL, MDA, and cholesterol concentrations and significantly higher LS-VitE values than control dogs. No significant correlations between MDA and antioxidant parameters were determined in either group. In conclusion, oxidative damage to lipids is already present and the antioxidant status is altered but not depleted in dogs with MMVD ACVIM B1. The antioxidant response to increased oxidative damage consists mainly of the activation of fat-soluble antioxidants. Further research is needed to evaluate the efficacy and targets of early antioxidant supplementation to prevent or ameliorate oxidative stress and mitigate disease progression in dogs with early-stage MMVD.

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Effects of intravenous anesthesia with sevoflurane combined with propofol on intraoperative hemodynamics, postoperative stress disorder and cognitive function in elderly patients undergoing laparoscopic surgery

Yang¹,

Chen²,

Dengguo

2022

Pak J Med Sci

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Objectives: To analyze the effects of intravenous anesthesia with sevoflurane combined with propofol on intraoperative hemodynamics, postoperative stress disorder and cognitive function in elderly patients undergoing laparoscopic surgery. Methods: Eighty elderly patients undergoing laparoscopic surgery in Xianning Central Hospital from September 2014 to February 2018. Enrolled patients were divided into observation group (n=40) and control group (n=40) according to the random regionalization method. Patients in the control group were given intravenous anesthesia with propofol, while those in the observation group were provided with a combined use of sevoflurane based on the method in the control group. The general surgical data, intraoperative hemodynamics, postoperative stress disorder and cognitive function were compared between the two groups. Results: There were no blood transfusions and no complications during operation in the two groups, and the operation completed successfully. There was no significant difference in the time of unconsciousness, intubation time, and duration of pneumoperitoneum establishment (p>0.05). However, the spontaneous breathing time, eye opening time upon calling and extubation time in observation group were shorter than those in control group (p<0.05). The heart rate (HR) in the two groups at intubation and at exploration was significantly higher than that at the time of entering the room (p<0.05), which was lower in observation group than that in control group (p<0.05). While there was no significant difference in the index at the other time points compared with that before entering the room and control group (p>0.05). The systolic blood pressure (SBP) had different degrees of change before intubation, after 0 minutes, three minutes and six minutes of intubation, after 0 minutes and five minutes of pneumoperitoneum establishment and at exploration when compared with that before entering the room (p<0.05). But the SBP at intubation and at exploration was significantly lower in observation group than that in control group (p<0.05). MAP was only decreased significantly at intubation compared with that before entering the room (p<0.05). At exploration, there was no significant fluctuation in the MAP level in observation group (p>0.05), but the MAP was increased significantly in control group (p<0.05). In addition, the postoperative stress disorder in observation group was milder than that in control group (p<0.05), and the postoperative cognitive function was better than that in control group (p<0.05). Conclusions: Intravenous anesthesia with sevoflurane combined with propofol has little effects on intraoperative hemodynamics and postoperative cognitive function in elderly patients undergoing laparoscopic surgery. Besides, it can obtain better recovery quality and have milder postoperative stress disorder than single use of propofol. doi: https://doi.org/10.12669/pjms.38.7.5763 How to cite this:Yang L, Chen Z, Xiang D. Effects of intravenous anesthesia with sevoflurane combined with propofol on intraoperative hemodynamics, postoperative stress disorder and cognitive function in elderly patients undergoing laparoscopic surgery. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5763 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antioxidant capacity of lipid- and water-soluble antioxidants in dogs with subclinical myxomatous mitral valve degeneration anaesthetised with propofol or sevoflurane

Cited by 4 publications

References 52 publications

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Evaluation of antioxidant status and lipid peroxidation in dogs with myxomatous mitral valve degeneration stage B1

Effects of intravenous anesthesia with sevoflurane combined with propofol on intraoperative hemodynamics, postoperative stress disorder and cognitive function in elderly patients undergoing laparoscopic surgery

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