Antioxidant capacity of broccoli sprouts subjected to gastrointestinal digestion

Rychlik, Joanna; Olejnik, Anna; Olkowicz, Mariola; Kowalska, Katarzyna; Juzwa, Wojciech; Myszka, Kamila; Dembczyński, Radosław; Moyer, Mary Pat; Grajek, W.

doi:10.1002/jsfa.6895

Cited by 22 publications

(13 citation statements)

References 37 publications

(45 reference statements)

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“…In recent years, there has been a growing interests in foods that are able to reduce the harmful effects of free radicals in the human body (Rychlik et al ., ). Free radicals can be generated during normal oxygen metabolism or induced by exogenous damage (Valko et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Broccoli seed extracts but not sulforaphane have strong free radical scavenging activities

Zou

Yuanfeng

Shen

et al. 2017

Int J of Food Sci Tech

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The abilities of broccoli seed extracts and purified sulforaphane (SF) to scavenge 2,2 0 -azinobis [3-ethylbenzothiazoline-6-sulphonate] (ABTS •+ ), 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and superoxide anions were studied. The free radical scavenging activities of broccoli seed extracts had no exact correlation with SF content, indicating that SF was not the main antioxidant component. The broccoli seed extracts were separated by high-speed countercurrent chromatography to obtain purified SF, which showed dosedependent free radical scavenging activities in the DPPH • and ABTS •+ assays, but its activities were weaker to those of ascorbic acid. The same trend was observed in the chemiluminescence assay. The results showed that broccoli seed extracts had strong free radical scavenging activities that were not attributable to SF.

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Section: Introductionmentioning

confidence: 97%

Broccoli seed extracts but not sulforaphane have strong free radical scavenging activities

Zou

Yuanfeng

Shen

et al. 2017

Int J of Food Sci Tech

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“…Isothiocyanates, the hydrolytic product of glucosinolate, is considered one of the antioxidant components, which motivates DNA protection from damage through its antioxidant activity [113,114]. The antioxidant property of broccoli may be direct by contributing in biochemical, cellular and physiological steps that inhibit free radical production, or indirect by inducing phase II enzymes that have a protective effect against OS [115]. The antioxidant activity of broccoli was observed in the human colon mucosa that exposed to oxidative stress [115].…”

Section: Broccoli Sproutsmentioning

confidence: 99%

“…The antioxidant property of broccoli may be direct by contributing in biochemical, cellular and physiological steps that inhibit free radical production, or indirect by inducing phase II enzymes that have a protective effect against OS [115]. The antioxidant activity of broccoli was observed in the human colon mucosa that exposed to oxidative stress [115]. Broccoli showed a potential anticancer activity due to its high content of glucosinolates [116].…”

Section: Broccoli Sproutsmentioning

confidence: 99%

Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors

Abdel-Hamid

Abass

Mohamed

et al. 2018

Biomedicine & Pharmacotherapy

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Hepatocellular carcinoma (HCC) is considered the most frequent tumor that associated with high mortality rate. Several risk factors contribute to the pathogenesis of HCC, such as chronic persistent infection with hepatitis C virus or hepatitis B virus, chronic untreated inflammation of liver with different etiology, oxidative stress and fatty liver disease. Several treatment protocols are used in the treatment of HCC but they also associated with diverse side effects. Many natural products are helpful in the co-treatment and prevention of HCC. Several mechanisms are involved in the action of these herbal products and their bioactive compounds in the prevention and co-treatment of HCC. They can inhibit the liver cancer development and progression in several ways as protecting against liver carcinogens, enhancing effects of chemotherapeutic drugs, inhibiting tumor cell growth and metastasis, and suppression of oxidative stress and chronic inflammation. In this review, we will discuss the utility of diverse natural products in the prevention and co-treatment of HCC, through its capturing of the common risk factors known to lead to HCC and shed the light on their possible mechanisms of action. Our theory assumes that shutting down the risk factor to cancer development pathways is a critical strategy in cancer prevention and management. We recommend the use of these plants side by side to recent chemical medications and after stopping these chemicals, as a maintenance therapy to avoid HCC progression and decrease its global incidence.

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“…Cruciferous vegetables could protect colonocytes against oxidative stress. Rychlik et al . reported that undigested extracts of raw broccoli sprouts and extracts subjected to an in vitro method of gastrointestinal digestion had a similar ability to protect NCM460 colon cells against H 2 O 2 ‐induced oxidative DNA damage.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3]18,19 Cruciferous vegetables could protect colonocytes against oxidative stress. Rychlik et al 20 reported that undigested extracts of raw broccoli sprouts and extracts subjected to an in vitro method of gastrointestinal digestion had a similar ability to protect NCM460 colon cells against H 2 O 2 -induced oxidative DNA damage. Cells were incubated with the extracts for only 1 h before exposure to H 2 O 2 , so protection was tentatively attributed to direct antioxidant effects of phenolic compounds such as sinapic acid, which were resistant to gastrointestinal digestion.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effect of raw and blanched‐frozen broccoli on DNA damage in colonocytes

Lynn

Fuller

Collins

et al. 2015

Cell Biochemistry & Function

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(2015).Comparison of the effect of raw and blanched-frozen broccoli on DNA damage in colonocytes. Cell Biochemistry and Function, 33 (5), 266-276. diet, whereas blanched-frozen broccoli had no significant effect. Both broccoli diets had no 25 2 significant effect on plasma antioxidant status or hepatic and colonic XME. This study is the 26 first to report that the consumption of raw broccoli can damage DNA in porcine colonocytes. Copyright and re-use policy

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Antioxidant capacity of broccoli sprouts subjected to gastrointestinal digestion

Abstract: The results lend support to the possible application of BS as a rich source of antioxidants to improve the defensive system against oxidative stress in the human colon mucosa.

Cited by 22 publications

References 37 publications

Broccoli seed extracts but not sulforaphane have strong free radical scavenging activities

Broccoli seed extracts but not sulforaphane have strong free radical scavenging activities

Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors

Comparison of the effect of raw and blanched‐frozen broccoli on DNA damage in colonocytes

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