Antioxidant Capacity and Phenolics Content of Apricot (Prunus armeniaca L.) Kernel as a Function of Genotype

Korekar, Girish; Stobdan, Tsering; Arora, Ramesh; Yadav, Ashish; Singh, Shashi Bala

doi:10.1007/s11130-011-0246-0

Cited by 68 publications

(38 citation statements)

References 23 publications

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“…Total phenols were found to correlate negatively with the EC 50 values and significantly (r = -0.9455, p < 0.01). The total tartaric esters and total flavonols correlate with with the EC 50 values also, but lower than total phenols (r= -0.7578 and -0.6158, p < 0.05, respectively), which is in agreement with data presented by others [9,10,[21][22][23]. The strong negative correlation was found between total acids and the EC 50 values (r = -0.9673, p < 0.01) and also between individual acids and the EC 50 values (gallic acid, r = -0.9047).…”

Section: Discussionsupporting

confidence: 91%

Antioxidant and Antimicrobial Activity of Polyphenol Extracts from Wild Berry Fruits Grown in Southeast Serbia

Radovanović¹,

Anđelković²,

Radovanović³

et al. 2013

Trop. J. Pharm Res

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Purpose: To assess the antioxidant and antimicrobial activities of polyphenolic extracts of three wild red wild berry fruit species from Southeast Serbia, viz, European cornel (Cornus mas), blackthorn (Prunus spinosa L.) and wild blackberry (Rubus fruticosus). Methods: Polyphenol content was determined using spectrophotometric and High performance liquid chromatography (HPLC) methods. Antioxidant activity was estimated by 2,2`-diphenyl -1 -picrylhydrazyl (DPPH) test while reliminary antimicrobial tests were carried out by disc diffusion method in which antibacterial activity was evaluated by measuring the zone of inhibition against test bacterial strains. Broth microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results: The highest amount of total phenols was found in

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Section: Discussionsupporting

confidence: 91%

Antioxidant and Antimicrobial Activity of Polyphenol Extracts from Wild Berry Fruits Grown in Southeast Serbia

Radovanović¹,

Anđelković²,

Radovanović³

et al. 2013

Trop. J. Pharm Res

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“…MEDL has also been shown to contain high TPC value, which have been associated with high antioxidant activity [37,38] as well as anti-inflammatory activity [39,40]. These claims are in line with previous findings by Wu et al [27] who reported that TPC-rich extract of Laggera pterodonta exerts both hepatoprotective and antioxidant activities when assessed using the in vitro primary cultured neonatal rat hepatocytes.…”

Section: Discussionsupporting

confidence: 75%

Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride- induced acute liver injury in rats

Kamisan

Yahya

Mamat

et al. 2014

BMC Complement Altern Med

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BackgroundDicranopteris linearis (family Gleicheniaceae) has been reported to possess anti-inflammatory and antioxidant activities but no attempt has been made to study its hepatoprotective potential. The aim of the present study was to determine the hepatoprotective effect of methanol extracts of D. linearis (MEDL) against carbon tetrachloride (CCl4)-induced acute liver injury in rats.Methods6 groups (n = 6) of rats received oral test solutions: 10% dimethyl sulfoxide (DMSO), 200 mg/kg silymarin, or MEDL (50, 250, and 500 mg/kg), once daily for 7 consecutive days, followed by hepatotoxicity induction with CCl4. Blood and liver were collected for biochemical and microscopic analysis. The extract was also subjected to antioxidant studies (e.g. 2, 2-diphenyl-1-picrylhydrazyl (DPPH)- and superoxide anion-radical scavenging assays, oxygen radical absorbance capacity (ORAC) test and total phenolic content (TPC) determination), phytochemical screening and HPLC analysis.ResultsPretreatment with MEDL and silymarin significantly (P < 0.05) reduced the serum levels of AST, ALT and ALP, which were increased significantly (P < 0.05) in DMSO-pretreated group following treatment with CCl4. Histological analysis of liver tissues in groups pretreated with MEDL and silymarin showed mild necrosis and inflammation of the hepatocytes compared to the DMSO-pretreated group (negative control group). The MEDL showed higher DPPH- and superoxide anion-radical scavenging activity as well as high TPC and ORAC values indicating high antioxidant activity.ConclusionsMEDL exerts hepatoprotective activity that could be partly contributed by its antioxidant activity and high phenolic content, and hence demands further investigation.

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“…Interestingly, we observed higher antioxidant capacity in some lichen extracts in comparison with the antioxidant capacities of native plants of trans-Himalayan cold desert [48], [75], that signifies the importance of lichens as therapeutic agents. Therefore, the trans-Himalayan saxicolous lichens might be a potential resource of natural antioxidants for their high antioxidant capacities that may be attributed to the elevated content of diverse secondary metabolites.…”

Section: Discussionmentioning

confidence: 65%

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

et al. 2014

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Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol and water extracts of the lichens were evaluated for their antioxidant capacities. The lichen extracts showing high antioxidant capacities and rich phenolic content were further investigated to determine their cytotoxic activity on human HepG2 and RKO carcinoma cell lines. The ferric reducing antioxidant power (FRAP), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) radical scavenging capacities and β-carotene-linoleic acid bleaching property exhibited analogous results where the lichen extracts showed high antioxidant action. The lichen extracts were also found to possess good amount of total proanthocyanidin, flavonoid and polyphenol. The methanolic extract of Lobothallia alphoplaca exhibited highest FRAP value. Methanolic extract of Xanthoparmelia stenophylla showed the highest ABTS radical scavenging capacity. The n-hexane extract of Rhizoplaca chrysoleuca exhibited highest DPPH radical scavenging capacity. Highest antioxidant capacity in terms of β-carotene linoleic acid bleaching property was observed in the water extract of Xanthoria elegans. Similarly, Melanelia disjuncta water extract showed highest NO scavenging capacity. Among n-hexane, methanol and water extracts of all lichens, the methanolic extract of Xanthoparmelia mexicana showed highest total proanthocyanidin, flavonoid and polyphenol content. From cytotoxic assay, it was observed that the methanolic extracts of L. alphoplaca and M. disjuncta were exhibiting high cytotoxic effects against cancer cell growth. Similarly, the water extract of Dermatocarpon vellereum, Umbilicaria vellea, X. elegans and M. disjuncta and the methanolic extract of M. disjuncta and X. stenophylla were found to possess high antioxidant capacities and were non-toxic and may be used as natural antioxidants for stress related problems. Our studies go on to prove that the unique trans-Himalayan lichens are a hitherto untapped bioresource with immense potential for discovery of new chemical entities, and this biodiversity needs to be tapped sustainably.

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Antioxidant Capacity and Phenolics Content of Apricot (Prunus armeniaca L.) Kernel as a Function of Genotype

Cited by 68 publications

References 23 publications

Antioxidant and Antimicrobial Activity of Polyphenol Extracts from Wild Berry Fruits Grown in Southeast Serbia

Antioxidant and Antimicrobial Activity of Polyphenol Extracts from Wild Berry Fruits Grown in Southeast Serbia

Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride- induced acute liver injury in rats

Antioxidant Capacities, Phenolic Profile and Cytotoxic Effects of Saxicolous Lichens from Trans-Himalayan Cold Desert of Ladakh

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