Antioxidant Capacity and Bioactive Contents of Mulberry Species from Eastern Anatolia Region of Turkey

Gündoğdu, Muttalip; Tunçtürk, Murat; Berk, Selma Kuru; Şekeroğlu, Nazım

doi:10.5530/ijper.52.4s.82

Cited by 18 publications

(11 citation statements)

References 14 publications

(24 reference statements)

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“…Numerous researches have proven antioxidant properties of M. nigra with different in vitro methods, including DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay [ 15 , 23 , 24 , 25 , 26 , 28 , 61 , 70 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ], ABTS (2,2’-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid) radical scavenging assay [ 15 , 91 , 94 , 99 , 100 , 101 , 102 , 103 , 107 , 110 , 112 , 113 , 114 , 115 , 116 , 117 ], reducing power assay [ 15 , 99 , 113 , 118 , 119 ], superoxide anion radical (O2 − ) scavenging assay [ 15 …”

Section: Antioxidant Activitymentioning

confidence: 99%

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

2019

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Mulberry plants belonging to the Moraceae family have been grown for the purpose of being the nutrient source for silk worm and raw materials for the preparation of jams, marmalades, vinegars, juices, wines, and cosmetics. Morus nigra L. (black mulberry) is native to Southwestern Asia, and it has been used as a traditional herbal medicine for animals and humans. In this article, recent research progress on various biological and pharmacological properties of extracts, fractions, and isolated active constituents from different parts of M. nigra are reviewed. M. nigra exhibited a wide-spectrum of biological and pharmacological therapeutic effects including antinociceptive, anti-inflammatory, antimicrobial, anti-melanogenic, antidiabetic, anti-obesity, anti-hyperlipidemic, and anticancer activities. M. nigra also showed protective effects against various human organs and systems, mainly based on its antioxidant capacity. These findings strongly suggest that M. nigra can be used as a promising nutraceutical resource to control and prevent various chronic diseases.

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Section: Antioxidant Activitymentioning

confidence: 99%

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

2019

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“…By now, anticancer, antiproliferative, anticholinesterase, antityrosinase, antioxidant, and other biological activities of numerous medicinal and aromatic plants (MAPs) and secondary metabolites isolated from MAPs were analysed in our laboratory (Akgunlu et al, 2016;Sekeroglu et al, 2017;Gezici et al, 2017;Belkhodja et al, 2017;Karik et al, 2018;Gundogdu et al, 2018;Senol et al, 2018;Gezici, 2018;Das et al, 2019;Shida et al, 2019;Gezici and Sekeroglu, 2019a;Gezici and Sekeroglu, 2019b;Gezici, 2019a;Gezici 2019b;Gezici, 2019, Sekeroglu et al, 2019 in press). Take into consideration our ongoing projects, evaluation cancer protective potentials against human cancer cells, investigating neuroprotective activities through enzyme inhibitions on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and TYR (tyrosinase) enzymes, along with determination of antioxidant capacities of extracts obtained from red hulls, kernels and oleo-gum resins of Pistachio (P. vera L.) are the main objectives of the presented research.…”

Section: Introductionmentioning

confidence: 99%

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Gezici¹

2019

International Journal of Agriculture Environment and Food Sciences

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This research was performed to assess cancer prevention and neuroprotective capacities of different parts of Pistachio (Pistachio vera L.). Red hulls, kernels and oleo-gum resins of Pistachio were extracted with methanol-MeOH and distilled water-dH 2 O, and subjected to in vitro biological assays varying from 100 to 1000 μg mL −1 concentrations. Their anticancer activities were evaluated against A549, MCF-7, and HeLa human cancer cells. Neuroprotective activities of the extracts were tested through enzyme inhibition on AChE, BChE, and TYR, which are closely related to pathogenesis of neurobiological disorders, particularly Alzheimer's and Parkinson's diseases. Due to cancer and neurodegenerative diseases are associated with oxidative damage, the extracts were analyzed for their antioxidant activities. With respect to free radical scavenging activities of the extracts, red hull extracts were found as the most potent ones both DPPH (67.95±1.13 to 80.55±0.12%) and ABTS (86.92±0.10 to 92.04±1.06%) radicals. The highest anticancer activity were determined in MeOH and dH 2 O extracts obtained from oleo-gum resin against HeLa cells (IC 50 = 18.50±0.85 and 28.97±0.08 µg mL-1 , p< 0.01, respectively), whilst dH 2 O-kernel extract was found to have the weakest anticancer activity towards A549 cells (IC 50 = 268.66±1.02 µg mL-1 , p< 0.01). Neuroprotective potentials on AChE and BChE enzymes were resulted in the superiority of dH 2 O-red hull extract was exerted the highest inhibition on AChE and BChE enzymes with 81.50±0.08 and 62.96±1.01% inhibition, respectively. However, dH 2 O extract from oleo-gum resin showed the highest inhibitory effect on TYR enzyme (58.16±0.18% inhibition). P. vera is of valuable nutritional source for human diet. Other than kernel parts used as food, waste parts like red hulls and oleo-gum resins have been proven as a potential pharmacological source. Consequently, this study reveals that non-food parts of Pistachio could be valuable source for pharmaceutical industry.

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“…Antioxidant activities of the extracts were performed using in vitro methods including 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing capacity (CUPRAC) (Chaturvedi, 2012;Gezici et al, 2017;Sekeroglu et al, 2017;Gundogdu et al, 2018;Gezici and Sekeroglu, 2019b). The extracts and commercial antioxidant standards were dissolved in DMSO at different concentrations, ranging from 100 g ml -1 to 1000 g ml -1 for the antioxidant assays.…”

Section: Antioxidant Activity Analysesmentioning

confidence: 99%

Original article Astragalus neurocarpus Bioss. as a potential source of natural enzyme inhibitor associated with Alzheimer’s and Parkinson diseases along with its rich polyphenolic content and antioxidant activities

Şekeroğlu¹,

Gezici²

2019

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Astragalus neurocarpus Bioss. (AN), a member of the Fabaceae family, is a traditional medicinal plant that its root parts have been known as strengthening the immune system. As far as our literature survey could ascertain, enzyme inhibitory activity, free radical scavenging and reducing antioxidant power activities of AN have not been reported elsewhere previously. Therefore, the present study was performed to assess total polyphenolic contents, antioxidant activities and neuroprotective potentia ls of the ethanol a nd water extra cts from aerial part and root of the plant.Total phenol and flavonoid contents of the extracts were determined spectrophotometrically. Antioxidant activity was analysed by using in vitro DPPH, ABTS, FRAP and CUPRAC assays. Neuroprotective activities of the extracts were assessed through enzyme inhibition on AChE, BChE and TYR. Regarding of total phenol and flavonoid quantities, all the extracts obtained from the aerial parts possessed higher polyphenolic contents, when compared to the root extracts. Ethanol extract prepared from the aerial parts of the plant were found the highest amount of total flavonoid quantity (179.34 ± 1.02 mg/g extract, as QE), while ethanol extract prepared from the root part possessed the lowest amount of total flavonoid quantity (49.73 ± 1.56 mg/g extract, as QE). The tested extracts were fou nd to have higher inhibition a gainst cholinestera se enzymes than those of the tyrosinase enzyme. Cholinesterase inhibitory activity assays on AChE and BChE enzymes were resulted in the superiority of the ethanol extracts obtained from the aerial parts (68.14 ± 0.03% and 59.44 ± 1.02% inhibition, respectively). According to antioxidant assays, all the extracts obtained from different parts of the plant exhibited remarkable activities on DPPH, ABTS and FRAP, whilst they were moderate effects on CUPRAC.

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Antioxidant Capacity and Bioactive Contents of Mulberry Species from Eastern Anatolia Region of Turkey

Cited by 18 publications

References 14 publications

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Original article Astragalus neurocarpus Bioss. as a potential source of natural enzyme inhibitor associated with Alzheimer’s and Parkinson diseases along with its rich polyphenolic content and antioxidant activities

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