Antioxidant, antiproliferative, and acetylcholinesterase inhibition activity of amino alcohol derivatives from 1,4-naphthoquinone

Crystal structure and Hirshfeld surface analysis of 1-(tert-butylamino)-3-mesitylpropan-2-ol hemihydrate

“…In particular, the -amino alcohol moiety is the predominant structural motif in a series of natural and synthetic biologically active molecules (Lee & Kang, 2004). Amino alcohol derivatives are currently being studied for their antimicrobial, antifungal, antioxidant, cytotoxic, enzyme inhibitory and other important biological activities, which have been well documented in recent works (Baker et al, 2021;Estolano-Cobia ´n et al, 2020;Tafelska-Kaczmarek et al, 2020).…”

Optimization of Ultrasound-Assisted Extraction of Bioactive Compounds from Acacia Seyal Gum Using Response Surface Methodology and Their Chemical Content Identification by Raman, FTIR, and GC-TOFMS

“…The 1,2,3,12a-Tetrahydro-6,9,10-trimethoxy-2-oxo-12H-benz(6,7) oxepino(2,3,4-i,j) isoquinoline alkaloid compound with antitumor activity was also detected and reported on by various researchers for its biological activities [93]. R)-(-)-2-Amino-1-propanol (alaninol) is one of the amino alcohol derivatives that poses antioxidant and anti-proliferative activity [94]. Compound like Monoalkylamines, isobutylamine, and N, N-dimethyl-4-nitroso-3-(trimethylsilyl) aniline, are phenylamine compounds with antitumor activity found in the analysis results [95].…”

A Green Multicomponent Domino Mannich‐Michael Reaction to Synthesize Novel Naphthoquinone‐Polyphenols with Antiproliferative and Antioxidant Activities

“…[22][23][24][25][26][27] Several pharmacological studies demonstrate that naphthoquinones and their derivatives have a range of anticancer activities, such as DNA intercalations, inhibition of DNA polymerases, modulation, and/or inhibition of protein kinase signaling pathways, inducing DNA breakage, chromosomal modifications and redox cycling transitions. [28] Figure 1 shows some synthetic structures with an anticancer activity that have been studied recently. [22,23,[28][29][30][31][32][33] Organic synthesis is constantly enriched by the improvement of synthetic methodologies and the development of new reactions.…”

“…[28] Figure 1 shows some synthetic structures with an anticancer activity that have been studied recently. [22,23,[28][29][30][31][32][33] Organic synthesis is constantly enriched by the improvement of synthetic methodologies and the development of new reactions. The paradigms of organic synthesis have changed from the traditional concept of using only chemical yield to define efficiency to one in which the economic and ecological values are also considered.…”

“…More specifically, 1,4‐naphthoquinones are an important scaffold, common in the structure of various natural products, [19–21] and are present in synthetic compounds that exert diverse biological and pharmaceutical applications as antibacterial, antifungal, and antitumor agents [22–27] . Several pharmacological studies demonstrate that naphthoquinones and their derivatives have a range of anticancer activities, such as DNA intercalations, inhibition of DNA polymerases, modulation, and/or inhibition of protein kinase signaling pathways, inducing DNA breakage, chromosomal modifications and redox cycling transitions [28] . Figure 1 shows some synthetic structures with an anticancer activity that have been studied recently [22,23,28–33] …”