Antioxidant, antimicrobial, and skin-whitening effects and quantitative analysis of phenolic compounds in Korean wild Chrysanthemum flowers via HPLC/UV

So, Jeong; Lee, Hak-Dong; Kim, Ji Hyun; Lee, Sanghyun; Lim, Jin Hee

doi:10.1007/s13580-023-00570-7

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Another study reported that C. zawadskii var. lucidum flowers, containing high levels of 3- O -caffeoylquinic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, and acacetin 7- O -rutinoside, exhibited skin-whitening activity by inhibiting melanin production in α-melanocyte-stimulating hormone-induced B16F10 cells [ 53 , 54 , 55 ]. The study also confirmed their antimicrobial activity against Staphylococcus aureus , Pseudomonas aeruginosa , and Candida albicans .…”

Section: Discussionmentioning

confidence: 99%

Comparative Antioxidant Potentials and Quantitative Phenolic Compounds Profiles among the Flowers and Leaves from Various Chrysanthemum morifolium Cultivars

Doan,

Tran,

Nguyen

et al. 2024

Pharmaceuticals

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Chrysanthemum morifolium is a valuable plant that contains a wide range of phytochemical compounds and exhibits various biological activities. Ethanol extracts from both the leaves and flowers of 17 different cultivars of C. morifolium were tested for antioxidant activities using the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) assays and were quantitatively analyzed for 12 phenolic compounds using high-performance liquid chromatography with diode-array detection. We found that the ‘Ford’ and ‘Raina’ cultivars demonstrated strong antioxidant abilities and high phenolic compound contents compared to other cultivars, while the flowers of ‘Cielo’ and the leaves of ‘White Cap’ exhibited low antioxidant capacity in both assays. The ‘Cielo’ cultivar also displayed the lowest compound contents. Additionally, in most samples, 3,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid stood out as high-content compounds in the extracts. This study provides foundational knowledge that can be used for selecting appropriate C. morifolium cultivars for further research. Moreover, the ‘Ford’ and ‘Raina’ cultivars, containing high amounts of bioactive compounds and showing superior antioxidant ability, could be applied to produce health-beneficial products.

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Section: Discussionmentioning

confidence: 99%

Comparative Antioxidant Potentials and Quantitative Phenolic Compounds Profiles among the Flowers and Leaves from Various Chrysanthemum morifolium Cultivars

Doan,

Tran,

Nguyen

et al. 2024

Pharmaceuticals

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Evaluation of Bioactive Functions and Quantitative Analysis of Phenolic Compounds of Glehnia littoralis from Different Regions

Yoon,

Lee,

Choi

et al. 2024

Horticulturae

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Glehnia littoralis F. (GLF), a perennial herb indigenous to the coastal areas of northern Pacific countries is widely utilized in medicine for various diseases and symptoms. The current study aimed to determine the relationship between phytochemicals and their diverse functional abilities. High-performance liquid chromatography and a photodiode array detector were used to identify chlorogenic acid (1), rutin (2), isoquercitrin (3), psoralen (4), 8-methoxy psoralen (5), and bergapten (6). 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+)- and 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical-scavenging assays were conducted. It was found that GLF from the Chungnam Province had a higher content of compounds 4–6 contents of approximately 51.29 µmoL/g, which was primarily composed of bergapten (6) (44.44 µmoL/g). Moreover, GLF from Jeju Island exhibited the strongest ABTS+- and DPPH-radical-scavenging activities, with IC50 values of 6.69 mg/mL and 10.26 mg/mL, respectively, followed by Chungnam Province and Jeonnam Province. In contrast, the radical-scavenging activities of GLF did not correlate with compounds 4–6 (furanocoumarins) and were predicted to be related to compounds 1–3. These differences in chemical composition and biological functions are consistent with differences in environmental conditions. Therefore, GLF with high amounts of flavonoid compounds such as rutin and isoquercitrin could potentially be utilized as herbal medicines; however, further research into their additional biological effects is needed.

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Phytochemical Profile, Antioxidant, Anti-Atopic, and Anti-Inflammatory Activities of Filipendula glaberrima Nakai at Different Growth Stages

Lee,

Tonog,

et al. 2024

Pharmaceuticals

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Since atopic dermatitis is an inflammatory skin disease, natural remedies, such as Filipendula glaberrima Nakai (FG), with anti-inflammatory properties are possible promising therapeutic options. This study aimed to investigate the therapeutic potential of FG extracts at different growth stages. Seven compounds were isolated from the FG leaf extracts using open-column chromatography, and they were analyzed using HPLC. The extracts were further evaluated for their total polyphenol and flavonoid content (TPC and TFC). The in vitro antioxidant properties of the FG extracts were evaluated using radical scavenging assays, whereas their anti-inflammatory activities were assessed by evaluating their ability to inhibit the production of inflammation-associated biomarkers using the Griess assay and ELISA, respectively. The MTT assay was used to evaluate the viability and cytotoxicity of the FG extracts in keratinocyte cell lines. The results showed that the full-flowering stage exhibited the highest TPC, TFC, and antioxidant activities, thus suggesting a positive correlation between these properties. All FG extracts showed significant anti-inflammatory activity by inhibiting the production of pro-inflammatory biomarkers in lipopolysaccharide-stimulated macrophages. Additionally, the FG extracts suppressed the production of cytokines and chemokines in keratinocytes, indicating their anti-atopic potential. HPLC analysis revealed that the full-flowering stage had the highest content of all the analyzed phytochemicals (gallic acid, (+)-catechin, hyperin, miquelianin, astragalin, afzelin, and quercetin). These results suggest that the full-flowering stage of FG is the most promising source for therapeutic applications owing to its superior phytochemical profile and biological activities. This study highlights the potential of FG extracts, particularly in its full-flowering stage, as a natural therapeutic agent for the management of inflammation-related diseases, and it can also serve as a reference for further research on FG.

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Antioxidant, antimicrobial, and skin-whitening effects and quantitative analysis of phenolic compounds in Korean wild Chrysanthemum flowers via HPLC/UV

Cited by 3 publications

References 45 publications

Comparative Antioxidant Potentials and Quantitative Phenolic Compounds Profiles among the Flowers and Leaves from Various Chrysanthemum morifolium Cultivars

Comparative Antioxidant Potentials and Quantitative Phenolic Compounds Profiles among the Flowers and Leaves from Various Chrysanthemum morifolium Cultivars

Evaluation of Bioactive Functions and Quantitative Analysis of Phenolic Compounds of Glehnia littoralis from Different Regions

Phytochemical Profile, Antioxidant, Anti-Atopic, and Anti-Inflammatory Activities of Filipendula glaberrima Nakai at Different Growth Stages

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