Antioxidant, anticoagulant and mosquitocidal properties of water soluble polysaccharides (WSPs) from Indian seaweeds

Venkatesan, Manigandan; Arumugam, Velusamy; Pugalendi, Rubanya; Ramachandran, Karthik; Sengodan, Karthi; Ramkumar, Vijayan Sri; Sundaresan, Umamaheswari; Ramachandran, Saravanan; Pugazhendhi, Arivalagan

doi:10.1016/j.procbio.2019.05.029

Cited by 46 publications

(28 citation statements)

References 69 publications

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“…Biologically derived polysaccharides have the advantages of nontoxicity, biodegradability, and biocompatibility, which makes them ideal candidates for widespread use [ 5 ]. Polysaccharides isolated from marine algae, especially fucose-rich polysaccharides isolated from brown algae, exert a variety of effects, such as antioxidant [ 6 ], anti-inflammatory [ 7 ], antimicrobial [ 8 ], and anticancer [ 9 ] effects. However, high-molecular-weight polysaccharides show limited biological activity due to their large molecular weight, high viscosity, and complex structures, which hinder their ability to enter cells or bind to receptors [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction

Lee

Fernando

et al. 2021

Antioxidants

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Among the components derived from brown algae, anionic sulfated polysaccharides, which contain sulfated fucose as the major monosaccharide, exert significant biological activities. In this study, we purified and structurally characterized sulfated polysaccharides from brown algae, Sargassum binderi (S. binderi; SBPs), and evaluated their biological activity in vitro and in vivo. The SBPs were separated based on their charges and their biophysical properties were investigated according to their functional groups, structural features, and molecular weights using FTIR, NMR, and MALS. Among all the SBPs, Fraction 4 (SBP-F4), with an average molecular weight of 2.867 × 105 g/mol, had the highest polysaccharide and sulfate contents (75.15 ± 0.25% and 24.08 ± 0.18%, respectively). The biological activities of SBP-F4 were investigated further in vitro and in vivo. Our results showed that SBP-F4 significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in LPS-activated macrophages. Moreover, in the LPS-treated zebrafish model, a significant decrease in cell death and NO production was observed. Collectively, these results show that SBPs not only exert protective effects against LPS-induced cytotoxicity but also inhibit the activation and anti-inflammatory activity of macrophages. Therefore, polysaccharides derived from S. binderi are potential anti-inflammatory agents for use in clinical settings.

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Section: Introductionmentioning

confidence: 99%

Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction

Lee

Fernando

et al. 2021

Antioxidants

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“…Sulfated polysaccharides (SP) from marine sources were investigated to have good antioxidant, antitumor, and immunomodulating activities. It was suggested that, next to the pharmacological activities of SP, their physicochemical properties, like good water solubility, thickening, and solidity over a wide pH range, offer extra benediction for their use as a preservative in topical application products [10] 5 International Journal of Polymer Science the formulated product. From our data, we found that the FA does not show any indication of phase separation during the study period, which are consistent with the findings of Andrade et al [24].…”

Section: Resultsmentioning

confidence: 99%

“…The filtered extract was kept at RT, and it gets gelated. The gelated samples were dried out at 60°C overnight and stored in -20°C for further experiments [10].…”

Section: Extraction Of Agarmentioning

confidence: 99%

“…The samples were read at 570 nm (Tecan Multimode Multiwall Plate Reader, Austria). Percentage cytotoxicity was calculated as described earlier [10].…”

Section: Formulation Of Agar (Fa)mentioning

confidence: 99%

“…The polysaccharides are major components of brown seaweed, accounting for 40% of the dry weight. The hot water extract of agar biomass is loaded in low molecular weight, water-soluble polysaccharides, (WSC) and insoluble in aqueous medium [10]. 7 International Journal of Polymer Science investigation of chromophore associations of atoms identified by energetically absorbing electronic transitions.…”

Section: Phytochemical Composition Of Famentioning

confidence: 99%

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Antiskin Cancer and Antioxidant Activities of Formulated Agar from Brown Seaweed Laminaria digitata (Hudson) in Dimethyl Benzanthracene-Induced Swiss Albino Mice

George

Thabitha

Vignesh

et al. 2021

International Journal of Polymer Science

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This study explores the antiskin cancer effect of formulated agar (FA) from Laminaria digitata on dimethyl benzanthracene- (DMBA-) induced skin cancer mice. The agar was extracted and formulated (emulgel), and FA was biochemically characterized. The in vitro cytotoxicity of FA was tested using NTT 3T3 mice fibroblast cells. The mice were divided into 5 groups: group 1 served as control mice, group 2 mice were considered as DMBA-induced cancer control, group 3 mice were FA pretreated (low dose) + DMBA-induced mice, group 4 mice were FA pretreated (high dose) + DMBA-induced mice, and group 5 were positive control + DMBA-induced mice. The behaviour and biochemical markers of cancer were significantly decreased in group 2 (DMBA-induced) mice, which were brought to near normalcy by FA pretreated mice (groups 3 and 4). The levels of p53 and keratin were significantly elevated in group 2 mice and these levels were decreased in 3 and 4 mice as well. The histopathological examination of DMBA-induced mice was shown degenerated cervical patches in the skin, cirrhosis in liver, oedema in the renal tissue, and swollen and damage in cardiac tissue, which were reduced for the mice applied with FA. This confirms that FA pretreatment offered potential antiskin cancer property.

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Flame retardancy, smoke suppression and enhancement properties of Enteromorpha based flame retardants onEPDM

Lan

Zhou

Zhao

et al. 2022

J of Applied Polymer Sci

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Enteromorpha as a waste from marine pollution brings great pressure to environmental governance every year, especially for China. Under the premise of shortage of industrial materials, taking appropriate measures can turn waste into wealth, which will benefit us a lot. In this work, a bio-based reinforcing type flame retardant based on Enteromorpha is designed. The designed Enteromorpha based flame retardant system mainly is focused on the reinforcing action and the flame retardant effects on ethylene-propylene-diene tripolymer (EPDM) systemically. Therefore, with the emergence of innovate reinforcing type Enteromorpha flame retardants in the future, the application of Enteromorpha in the polymer flame retardants field will surely usher in bright development.

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Antioxidant, anticoagulant and mosquitocidal properties of water soluble polysaccharides (WSPs) from Indian seaweeds

Cited by 46 publications

References 69 publications

Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction

Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction

Antiskin Cancer and Antioxidant Activities of Formulated Agar from Brown Seaweed Laminaria digitata (Hudson) in Dimethyl Benzanthracene-Induced Swiss Albino Mice

Flame retardancy, smoke suppression and enhancement properties of Enteromorpha based flame retardants onEPDM

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