Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved

Miguel, Constanza Ágata; Noya-Riobó, María Victoria; Mazzone, Graciela L.; Villar, Marcelo J.; Coronel, Marı́a Florencia

doi:10.1016/j.neuint.2021.105188

Cited by 40 publications

(29 citation statements)

References 73 publications

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“…Resveratrol (Res), as a potential SCI therapeutic drug, exhibits a variety of pharmacological effects, such as good antioxidant, anti-inflammatory, neuroprotective, and antiapoptotic properties (Fu et al, 2018 ; Huang et al, 2019 ; Fan et al, 2021 ). However, due to its poor water solubility, low bioavailability, and difficulty in crossing physiological barriers to reach the injury site, its application in SCI is limited greatly (Zhang et al, 2014 ; Miguel et al, 2021 ). To solve these problems, CM was used as the delivery carrier of Res to improve its water solubility and bioavailability in this study.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury

Zou

et al. 2022

Drug Delivery

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Spinal cord injury (SCI) is a serious central nervous system disease, and secondary injury, including oxidative stress, the inflammatory response and accompanying neuronal apoptosis, will aggravate the condition. Due to the existence of the blood–spinal cord barrier (BSCB), the existing drugs for SCI treatment are difficulty to reach the injury site and thus their efficacy is limited. In this study, we designed chitosan-modified hollow manganese dioxide nanoparticles (CM) for the delivery of resveratrol to help it pass through the BSCB. Resveratrol (Res), a poorly soluble drug, was adsorbed into CM with a particle size of approximately 130 nm via the adsorption method, and the drug loading reached 21.39 ± 2.53%. In vitro dissolution experiment, the Res release of the loaded sample (CMR) showed slowly release behavior and reached about 87% at 36 h. In vitro at the cellular level and in vivo at the animal level experiments demonstrated that CMR could alleviate significantly oxidative stress by reducing level of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and increasing glutathione peroxidase (GSH) level. Additionally, immunofluorescence (iNOS, IL-1β, and Cl caspase-3) and western blot (iNOS, cox-2, IL-1β, IL-10, Cl caspase-3, bax, and bcl-2) were used to detect the expression of related factors, which verified that CMR could also reduce inflammation and neuronal apoptosis. These results indicated that CM, as a potential central nervous system drug delivery material, was suitable for SCI treatment.

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Section: Introductionmentioning

confidence: 99%

Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury

Zou

et al. 2022

Drug Delivery

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“…by lowering the concentration of C-reactive protein in the blood) and anti-apoptotic effects against central nervous system cells (incl. by stimulating kinase C and reducing the toxicity of β-amyloid in brain neurons) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Non-Commercial Grapevines Hybrids Fruits as a Novel Food of High Antioxidant Activity

Olędzki

Lutosławski

Nowicka

et al. 2022

Foods

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Non-commercial hybrid grapevine cultivars, usually used for dessert purposes or as ornamental garden plants, may contain a wealth of bioactive substances and thus can be regarded as highly valuable food resources. Antioxidant properties and selected groups of polyphenolic components in the three fractions of fruits: peel, pulp and juice; of five hybrid grape cultivars grown in Poland—Michigan, Alwood, Minnesota, V68021 and Beta—were analyzed and characterized. The liquid chromatography coupled with tandem mass spectrometry (LC-MS-PDA-Q/TOF and UPLC-PDA), total polyphenols, flavonoids and anthocyanins, and DPPH, ABTS and FRAP were used for evaluation of antioxidant potential qualitatively and quantitatively as well as simple reductive sugars were measured. The antioxidant activity and polyphenols content depend mainly on the grape fruit fraction, while they depend to a lesser extent on the cultivar of the hybrid grapes studied. It was confirmed that grape skins are characterized by high antioxidant activity and their bioactive characteristics are similar to many hybrid grape cultivars grown in southern and Mediterranean regions of Europe. Especially grape skins of Alwood and Beta cultivars were characterized by a particularly high content of polyphenolic compounds, mainly from the flavonoid and anthocyanin group and a low content of simple sugars.

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“…Resveratrol can also act as an activator of PPARalpha, enhancing the cell's ability to convert and catabolize fatty acids while inhibiting the expression of lipid-producing genes, including Srbf1 (Serrano et al, 2021). At the same time, the antioxidant activity of resveratrol has been repeatedly confirmed (Miguel et al, 2021). Because it has both hydrophilic and lipophilic properties, it may provide more effective protection than common antioxidants (such as vitamin C and vitamin E).…”

Section: Discussionmentioning

confidence: 99%

“…It can protect cells even during ethanol intoxication (Kasdallah-Grissa et al, 2007). The antioxidant mechanism of resveratrol may be related to its ability to reduce the superoxide and nitrite anions produced by neutrophils and macrophages, capture peroxy free radicals and/or hydroxyl free radicals, and reduce α-tocopherol radicals to regenerate endogenous tocopherol (Banez et al, 2020;Kasdallah-Grissa et al, 2007;Miguel et al, 2021). The hepatoprotective activity of resveratrol on fibrosis can be explained by its ability to produce more IL-10 to promote the polarization of M(LPS) to M(IL-4)-like macrophages (Yu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the impact on mouse livers of different amounts of Chinese Baijiu, beer, and wine consumption

WANG

et al. 2022

Food Sci. Technol

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Due to chronic alcohol consumption, alcoholic liver disease (ALD) has become the second most common liver disease in the world. The study was to explore the effects of consuming different amounts of various alcoholic beverages on the liver of mice. Results showed wine contained far more polyphenols and organic acids than beer and Chinese Baijiu. When daily alcohol consumption was low (less than 100 mL/60 kg/day), the liver and serum indicators of mice treated with alcohol, beer, Chinese Baijiu, and wine were not significantly d ifferent fr om th ose in sa line gr oup. At 25 0 mL /60 kg /day, be er us ed si gnificantly damaged the liver and caused adverse changes in serum components, while wine did not cause changes in serum, indicating that it may cause less damage due to the existence of a large number of polyphenols. When the daily consumption exceeded 500 mL/60 kg/day, all four alcoholic beverages significantly increased serum markers of hepatic injury and decreased serum total antioxidant capacity and liver antioxidant enzyme levels, resulting in liver fat accumulation and serious pathological damage. At this level, beer used caused the most damage and wine the least. This study explores the appropriate drinking amount of different alcoholic beverages and provides a scientific reference for alcohol consumption.

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Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved

Cited by 40 publications

References 73 publications

Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury

Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury

Non-Commercial Grapevines Hybrids Fruits as a Novel Food of High Antioxidant Activity

Comparative study on the impact on mouse livers of different amounts of Chinese Baijiu, beer, and wine consumption

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