Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy

Pisoschi, Aurelia Magdalena; A, Pop; Iordache, Florin; Stanca, Loredana; Geicu, Ovidiu Ionuț; Bîlteanu, Liviu; Serban, Andreea Iren

doi:10.1016/j.ejmech.2022.114175

Cited by 55 publications

(51 citation statements)

References 288 publications

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“…The severe complications of COVID19 include hyper inflammation and increased levels of reactive oxidative species (ROS) in the respiratory system [124]. Vitamin C can be toxic at high dosage [14,15,125].…”

Section: Plausibility Of the Direct Delivery Of Vitamin C And The Pot...mentioning

confidence: 99%

Vitamin C and its therapeutic potential in the management of COVID19

Reddy

Batra

et al. 2022

Clinical Nutrition ESPEN

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Section: Plausibility Of the Direct Delivery Of Vitamin C And The Pot...mentioning

confidence: 99%

Vitamin C and its therapeutic potential in the management of COVID19

Reddy

Batra

et al. 2022

Clinical Nutrition ESPEN

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“…The upregulation of systemic inflammation with pulmonary dysfunction in COVID-19 is accompanied by the production of ROS and a concomitant deficiency of antioxidants. Antioxidative enzymes such as SOD, CAT, and GPX, and nonenzymatic antioxidant and antiinflammatory molecules such as vitamins A, C, D [ 92 , 180 ] and E, melatonin, resveratrol, GSH, NAC, silymarin, quercetin, curcumin, propolis, thymoquinone, Boswellia, and hesperidin, were suggested as the therapeutic agents against COVID-19 and some of them are being evaluated in clinical trials [ 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 ]. Vitamin therapy was not suggested to replace classical antiviral and antiinflammatory treatments for COVID-19, but it could be used as an adjuvant therapy with other pharmacological treatments [ 190 ].…”

Section: Potentials For Therapeutic Approaches Based On Antioxidant T...mentioning

confidence: 99%

“…Antioxidative enzymes such as SOD, CAT, and GPX, and nonenzymatic antioxidant and antiinflammatory molecules such as vitamins A, C, D [ 92 , 180 ] and E, melatonin, resveratrol, GSH, NAC, silymarin, quercetin, curcumin, propolis, thymoquinone, Boswellia, and hesperidin, were suggested as the therapeutic agents against COVID-19 and some of them are being evaluated in clinical trials [ 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 ]. Vitamin therapy was not suggested to replace classical antiviral and antiinflammatory treatments for COVID-19, but it could be used as an adjuvant therapy with other pharmacological treatments [ 190 ]. A prospective, double-blinded, randomized parallel-controlled interventional clinical study evaluated the effect of antioxidant supplements in 87 hospitalized COVID-19 patients.…”

Section: Potentials For Therapeutic Approaches Based On Antioxidant T...mentioning

confidence: 99%

Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

et al. 2022

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The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

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“…α-TOH is a lipid-soluble antioxidant that serves for the preservation of cell membranes, as it acts as a defense against oxidative stress [ 124 ]. It traps reactive oxygen species, thus preventing the oxidative explosion associated with SARS-CoV-2 [ 125 ]. Vitamin E is able to reduce inflammatory cytokine production, promote T-cell proliferation and differentiation, and influence inflammatory responses in various tissues, including the lungs [ 126 ].…”

Section: Nutraceuticals and Dietary Supplements Against Covid-19 Dise...mentioning

confidence: 99%

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano

Iacopetta

Ceramella

et al. 2022

Foods

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The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The reduction of severe cases and deaths from COVID-19 led to increasing importance of a new disease called post-COVID syndrome. The term post-COVID is used to indicate permanency of symptoms in patients who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well as ozone therapy have been used to treat COVID-19 disease. Vaccines have then become available and administered worldwide to prevent the insurgence of the disease. However, the pandemic is not over yet at all given the emergence of new omicron variants. New therapeutic strategies are urgently needed. In this view, great interest was found in nutraceutical products, including vitamins (C, D, and E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), and curcumin. This review summarizes the role of nutraceuticals in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.

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Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy

Cited by 55 publications

References 288 publications

Vitamin C and its therapeutic potential in the management of COVID19

Vitamin C and its therapeutic potential in the management of COVID19

Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

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