Antioxidant, Anti-Inflammatory, and Cytotoxic Properties and Chemical Compositions of Filipendula palmata (Pall.) Maxim.

Abstract

Filipendula palmata (Pall.) Maxim. remains unexplored and underutilized resources with a high potential to improve human health. In this study, a new ursane-type triterpenoid, namely, 2α, 3β-dihydroxyurs-12-en-28-aldehyde (compound 10), and other 23 known compounds were isolated. 5 triterpenoids (compounds 6, 8, and 10–12), 11 flavonoids (compounds 13–15 and 17–24), 6 phenolic compounds (compounds 1, 2, 4, 5, 9, and 16), 2 sterols (compounds 3 and 7) were isolated from the aqueous solution extract of the aerial parts of F. palmata. The structures of all compounds were elucidated by the use of extensive spectroscopic methods such as infrared spectroscopy (IR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1H-NMR, and 13C-NMR. The solvent extractions of ethyl acetate fraction were evaluated for antioxidant activities using DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ABTS+ (2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) methods. The anti-inflammatory effects of the compounds were evaluated in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages. The extract cytotoxicity on the cancer cell lines MCF-7, HeLa, 4T1, and A549 was determined by MTT assay. As a result, compounds 10, 11, and 12 exhibited better antioxidant activity compared to the other compounds. Compounds 8–24 had different inhibitory effects on the release of NO, TNF-α, and IL-6 in LPS-stimulated RAW 264.7 cells. The new compound has shown a significant inhibiting effect on cancer cells, and the cell inhibition rate increased in a dose-dependent manner. Further research to elucidate the chemical compositions and pharmacological effects of F. palmata is of major importance towards the development and foundation of clinical application of the species.

Comparative and phylogenetic analyses of the chloroplast genomes of Filipendula species (Rosoideae, Rosaceae)

“…Filipendula species have long been utilized for medicinal purposes and most published papers have focused on the medicinal properties of these plants 11 , 12 . Their aerial parts (leave and flower) and underground organs (roots) are good resources of bioactive substances, including tannins, polyphenolic acid and essential oils, which have antioxidant, anticancer, anti-inflammatory, gastroprotective, anti-hyperalgesic, anti-genotoxic, and hepatoprotective effects 13 , 14 . Besides, the leaves of Filipendula can be processed into the herbal tea in Russia and other Siberia countries, which is used to relieve influenza and gout, to clean wounds and eyes 15 .…”

Antiviral Activity of Original Flavonoids-Containing Phytopreparation Against Human Alphaherpesvirus 2, Hepatitis C Surrogate Virus and Transmissible Gastroenteritis Coronavirus

“…Flavonoids such as apigenin from Petroselinum crispum [47], apiin from Petroselinum crispum and Apium graveolens, pectolinarin, isolinariin and pectolinarigenin from Linaria vulgaris [12,24,26,30,35,49] are of particular interest among phytopreparation's phenolic active pharmaceutical ingredients. Flavonoids (quercetin from Filipendula vulgaris [50], kaempferol from Petroselinum crispum [17], spireoside and isoquercitrin from Filipendula vulgaris [42] are also promising active substances with antiviral activity. According to European Agency for the Evaluation of Medicinal Products (1999) [16], Calendula officinalis flowers tincture inhibits the replication of herpes simplex viruses, influenza A2 and influenza APR-8 viruses in vitro.…”

<i>In-vitro</i> antioxidant, anti-inflammatory and cytotoxic activity of <i>Cucumis melo L. </i>of ethanolic extract

“…The availability of these fruit constituents may provide a rich source of natural drugs against the modern medicine. The cytotoxic effect of these fruit extracts is to be evaluated besides on the host cells (7). The safety of fruits as a potential therapeutically agents must be ascertained and the concomitant might be acceptable to the host cell.…”