Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates

Abstract

The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from Phoenix dactylifera L. parthenocarpic dates. The antioxidant activity was carried using DPPH radical scavenging activity. The result showed that parthenocarpic dates had strongly scavenging activity on DPPH reaching 94% with an IC50 value of 0.15 ± 0.011 mg/mL (p < 0.05). The anti-inflammatory potential was determined by the inhibitory effect of the aqueous ethanolic extract on phospholipase A2 activity as well as on carrageenan-induced paw oedema in mice. The in vitro study showed that the extract inhibited the phospholipase A2 activity with an IC50 value of 130 μg/mL and the in vivo study showed a significantly decrease in the paw oedema after 1 h compared to the control group. Finally, the antiproliferative activity of the aqueous ethanolic extract was assessed by MTT test against MCF-7 and MDA-MB-231 cancer cell lines. This extract was effective in inhibiting MDA-MB-231 and MCF-7 cancer cells growth with IC50 values of 8 and 18 mg/mL, respectively, after 72 h treatment. These results confirm the ethnopharmacological significance of Phoenix dactylifera L. parthenocarpic dates, which could add support for its pharmaceutical use.

Functional food and nutra‐pharmaceutical perspectives of date ( Phoenix dactylifera L.) fruit

“…Furthermore, the administration of these alcoholic extracts significantly enhanced the antioxidant level (Vitamin C, E, and A). EI Abed et al (2018) investigated the antimicrobial, anti‐inflammatory, and antioxidants potential of parthenocarpic dates extracts (water, ethanolic). These activities were determined through DPPH, phospholipase A 2 activity, and MTT test (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide), respectively.…”

Date Palm Extract (Phoenix dactylifera) PEGylated Nanoemulsion: Development, Optimization and Cytotoxicity Evaluation

“…Worldwide, more than 3000 date cultivars are known [12]. Saudi Arabia has a rich diversity of date cultivars of which Khalas, Sheshi, and Reziz are well known, especially in the Eastern Province of the Kingdom [13][14][15][16][17]. Although date pits represent around 11-18% of date fruit, they are considered of low market value due to their hard texture and contamination by fungi or insects during the processing of date fruits [18,19].…”

Towards the Utilization of Date Palm (<i>Phoenix dactylifera</i>) Leaves as a Rich Source of Antioxidants

“…However, the standard ascorbic acid recorded an IC 50 of 22.72µM (12µg). A report on date palm fruit conducted by El Abed et al [26] stated that the ethanolic extract of the fruit showed strong activity against DPPH and showed an IC 50 of 0.15±0.011mg/mL. On the other hand, the methanolic extracts of Deglet Nour, Medjhoul, and Barhee date palm leaves showed an IC 50 of 2.08, 2.11, and 2.14 mg/mL respectively when Gallic acid was used as standard [21].…”