Antioxidant, Anti-Inflammatory and Antiproliferative Activity of<i>Angelica Dahurica</i>Root Extracts

Pervin, Mehnaz; Hasnat, Abul; Debnath, Trishna; Park, Sa Ra; Kim, Da Hye; Lim, Beong Ou

doi:10.1111/jfbc.12046

Cited by 20 publications

(19 citation statements)

References 65 publications

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“…Extracts of Baizhi root have anti-oxidant properties (Pervin et al 2014 ; Wang et al 2017 ). Both reports have successfully used BHT as a standard to determine the antioxidant activity.…”

Section: Resultsmentioning

confidence: 99%

“…The multiple pharmacological effects of Baizhi root extracts include antioxidation (Piao et al 2004 ), anti-inflammatory (Pervin et al 2014 ), antiproliferative (Yousif et al 1999 ), skin whitening (Cho et al 2006 ), anti-tumor (Kim et al 2007 ), antimicrobial (Kwon et al 1997 ) and anti-Alzheimer effects (Marumoto and Miyazawa 2010 ). These effects are believed to be attributed to the plant’s rich furanocoumarin compounds such as imperatorin and isoimperatorin.…”

Section: Introductionmentioning

confidence: 99%

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Influence of harvest stage on the pharmacological effect of Angelica dahurica

Liang

Chang²,

Charng

2018

Bot Stud

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BackgroundBaizhi (Angelica dahurica) has been widely used as a traditional Chinese herbal medicine, functional food and cosmetic product ingredient, mostly because of the high furanocoumarin compounds in roots. The cropping system of Baizhi with its unique summer dormancy feature, is easily affected by the transition of its growth stages. The aim of this study was to analyze the quantity (size, form and dry weight [DW]) and quality (antioxidant and furanocoumarin content) of taproot and lateral root from three growth stages of Baizhi; vegetative (V-stage), summer dormancy (S-stage) and bolting stage (B-stage).ResultsRoot length and diameter were lower at V-stage than the other two stages, and S-stage had higher lateral root to total root ratio. However, the highest root DW was observed at S-stage. Antioxidant activity was revealed by 2,2-diphenyl-l-picrylhydrazyl and Fe2+ chelating assay, and the content of six furanocoumarin compounds, including xanthotoxin, bergapten, oxypeucedanin, imperatorin, phellopterin and isoimperatorin, was analyzed by liquid chromatography. Although the antioxidant activity was less at S-stage than the other stages, furanocoumarin contents showed little variation.ConclusionConsidering the high DW and stable furanocoumarin composition, S-stage is the best harvest stage than the other stages because of its richer total pharmacological content.

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“…Extracts of Baizhi root have anti-oxidant properties (Pervin et al 2014 ; Wang et al 2017 ). Both reports have successfully used BHT as a standard to determine the antioxidant activity.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of harvest stage on the pharmacological effect of Angelica dahurica

Liang

Chang²,

Charng

2018

Bot Stud

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“…The DPPH· scavenging activity was evaluated according to reference (Pervin et al . ) with slight modification in details. Briefly, 2.0 mL of diluted sample solution or positive control (BHT) was mixed with 2.0 mL of 0.1 mM DPPH solution (in methanol).…”

Section: Methodsmentioning

confidence: 99%

Antioxidant Activity and Phenolic Acids Profiles of Artemisia Selengensis Turcz Extracted with Various Methods by HPLC-QTOF-MS/MS

Zhang

Wang

et al. 2016

Journal of Food Biochemistry

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Effects of dynamic high pressure microfluidization (DHPM), microwave, ultrasound, maceration and high temperature, on the phenolic acids and antioxidant activity of Artemisia selengensis Turcz (AST) were investigated. Microwave exhibited the best extraction efficacy on phenolic compounds and flavonoids with the content of 40.30 μg GAE/mg Extract, and 37.75 μg RTE/mg Extract, respectively. Microwave extract (MWE) also showed the strongest DPPH· and HO· scavenging ability (IC50 value of 0.23 and 0.50 mg/mL, respectively), and reducing power (Ab0.3 value of 0.23 mg/mL). Quinic acid, 3 caffeoylquinic acids (CQAs), 2 coumaroylquinic acids, 4 dicaffeoylquinic acids (diCQAs) were identified as the major phenolic acids in AST using HPLC‐QTOF‐MS/MS, and 3‐CQA (63.71 μg/mL) showed the highest content followed by 1,5‐diCQA (17.91 μg/mL) and 3,5‐diCQA (13.50 μg/mL). MWE had the highest 3‐CQA and diCQAs. While, high temperature could promote the degradation of diCQAs, 3‐ and 4‐caffeoyl are more liable to decompose as compared with 1‐ and 5‐caffeoyl. Practical Application Over production of reactive oxygen species (ROS) in body will induce various chronic diseases. AST is an underutilized vegetable with many health benefits. This research indicates that AST possessed appreciating antioxidant activities and abundant phenolic acids, it is could be a potentail antioxidants resource and for prevention of chronic diseases associated with ROS. It also suggested that microwave could be a promising method for extracting the antioxidants in AST. Therefore, this research could lay a foundation for the high‐value application of AST in food, health care and natural therapy industry, and provide some methodological references for the development of antioxidants in AST.

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“…Total phenolic contents were determined by Folin-ciocalteu (FC) method as previously mentioned 30 with some changes. The extracts (1 mg/mL) and various concentrations of GA (0-100 µg/mL) were prepared.…”

Section: Total Phenolic Contentmentioning

confidence: 99%

Antioxidant, Anti-inflammatory, and Antiproliferative Activity of Mori Cortex Radicis Extracts

Bayazid

Kim²,

Park

et al. 2020

Natural Product Communications

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Mori Cortex Radicis (MCR) is a well-known Korean and Chinese folk medicine with anti-obesity, anti-inflammatory, anti-asthmatic, and hypoglycemic activities. This study was aimed to evaluate the total phenolic and flavonoid contents, as well as intracellular antioxidant and anti-inflammatory effects of water and 70% (v/v) ethanol extracts of MCR. The antioxidant activities of MCR extracts were determined with diphenyl-2-picrylhydrazyl and 2,2′-azinobis[3-ethylbenzothiazoline-6-sulfonic] scavenging activity assays. The suppressive activities of MCR extracts on the production of nitric oxide (NO*) and the expression of cytokines, c-Fos, activated p38-Mitogen-activated protein kinase (MAPK), and Nuclear factor Kappa B (NF-κB) and splenocytes proliferation in lipopolysaccharide-treated macrophages were determined. Furthermore, this study demonstrated the effects of MCR on reactive oxygen species production in murine macrophages. Mori Cortex Radicis restored deoxyribonucleic acid damages at higher concentrations of the extracts and significantly suppressed free radicals and NO* production. In this study, MCR significantly restored inflammatory responses and intracellular antioxidant activities in murine macrophages (RAW 264.7), which anticipated that MCR could be used as a natural anti-inflammatory agent.

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Antioxidant, Anti-Inflammatory and Antiproliferative Activity ofAngelica DahuricaRoot Extracts

Cited by 20 publications

References 65 publications

Influence of harvest stage on the pharmacological effect of Angelica dahurica

Influence of harvest stage on the pharmacological effect of Angelica dahurica

Antioxidant Activity and Phenolic Acids Profiles of Artemisia Selengensis Turcz Extracted with Various Methods by HPLC-QTOF-MS/MS

Antioxidant, Anti-inflammatory, and Antiproliferative Activity of Mori Cortex Radicis Extracts

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