Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius

Dufour, Dominic; Pichette, André; Mshvildadze, Vakhtang; Bradette‐Hebert, Marie‐Eve; Lavoie, Serge; Longtin, Angélique; Laprise, Catherine; Legault, Jean

doi:10.1016/j.jep.2006.10.021

Cited by 76 publications

(56 citation statements)

References 30 publications

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“…Pentacyclic triterpene compounds are well known to exert anti-inflammatory effects through targeting macrophages, oxidative stress mediators (ie, superoxide dismutase, prostaglandins, cyclooxygenase-2 or nitric oxide) [26,27] . To investigate whether betulin, a pentacyclic triterpene compound, has an effect on T cells, T cell subsets were analyzed 10 h after Con A injection.…”

Section: Resultsmentioning

confidence: 99%

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice

et al. 2016

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Hedyotis hedyotidea has been used in traditional Chinese medicine for the treatment of autoimmune diseases. However, the mechanisms underlying for the effect remain unknown. We previously showed that, among 11 compounds extracted from H hedyotidea, betulin produced the strongest suppressive effect on T cell activation. Here, we examined the hepatoprotective effects of betulin against acute autoimmune hepatitis in mice and the mechanisms underlying the effects. Freshly isolated mouse splenocytes were stimulated with concanavalin A (Con A, 5 μg/mL) in the presence of betulin, the cell proliferation was assessed with CSFE-dilution assay. Mice were injected with betulin (10, 20 mg· kg -1 ·d -1 , ip) for 3 d. One hour after the last injection, the mice were injected with Con A (15 mg/kg, iv) to induce acute hepatitis. Blood samples and liver tissues were harvested at 10 h after Con A injection, and serum transaminase levels and liver histopathology were detected; serum levels of proinflammatory cytokines, hepatic T lymphocyte ratios, and functional statuses of conventional T and NKT cells were also analyzed. Betulin (16 and 32 μmol/L) dose-dependently suppressed the proliferation of Con A-stimulated mouse splenocytes in vitro. In Con A-challenged mice, preinjection with betulin (20 mg· kg -1 ·d -1 ) significantly decreased the levels of proinflammatory cytokines IFN-γ, TNF-α and IL-6, and ameliorated liver injury. Furthermore, pretreatment with betulin (20 mg· kg -1 ·d -1 ) significantly inhibited the Con A-induced activation of NKT and conventional T cells, and decreased production of proinflammatory cytokines IFN-γ, TNF-α and IL-6 in these two cell populations. Betulin has immunomodulatory effect on overly activated conventional T and NKT cells and exerts hepatoprotective action in mouse autoimmune hepatitis. The findings provide evidence for the use of H hedyotidea and its constituent betulin in the treatment of autoimmune diseases.

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Section: Resultsmentioning

confidence: 99%

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice

et al. 2016

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“…Some triterpinoids are found to have promising anticancer and antioxidant activity. MEDP shows the presence of tannins and triterpenes which may act as anticancer and antioxidant principles with MEDP [26,27]. In our earlier studies, we found that MEDP possess hepatoprotective and antioxidant properties [28].…”

Section: Discussionmentioning

confidence: 99%

Antitumor Activity of <i>Diospyros peregrina</i> on Ehrlich Ascites Carcinoma in Mice

Raju

Ravindranath

et al. 2011

J. Sci. Res.

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The methanol extract of Diospyros peregrina (Ebenaceae) bark (MEDP) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing swiss albino mice. The extract was administered at the doses of 200 and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MEDP on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MEDP caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MEDP exhibited significant antitumor activity in EAC-bearing mice.

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“…Generally there is very tiny biological knowledge of the specific modes of action in the treatment of diabetes, but the article reviews show that this plant contains substance like sterol, flavanone, chalcone, triterpene acid, b-sitos-terol, ursolic acid, etc., which are frequently implicated as having antidiabetic effects [37,38].…”

Section: Reducing Power Capacitymentioning

confidence: 99%

Antidiabetic and antioxidant activities of methanol extract of Syzygium operculatum (Roxb.) Niedz. bark

2015

J Coast Life Med

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Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius

Cited by 76 publications

References 30 publications

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice

Antitumor Activity of <i>Diospyros peregrina</i> on Ehrlich Ascites Carcinoma in Mice

Antidiabetic and antioxidant activities of methanol extract of Syzygium operculatum (Roxb.) Niedz. bark

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