Antioxidant and α-Glucosidase Inhibition Activities of Solvent Fractions from Methanolic Extract of Sericea Lespedeza (Lespedeza cuneata G. Don)

김현영,; 고지연,; 송석보,; 김정인,; 서혜인,; 이재생,; 곽도연,; 정태욱,; 김기영,; 오인석,; 정헌상,; 우관식,

doi:10.3746/jkfn.2012.41.11.1508

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…The n-BuOH fraction (50-250 μg/mL) had the highest anti-oxidant activity among the four fractions. Our results support the observations of a previous study on the anti-oxidant activity of L. cuneata extracts [22] and demonstrate that the EtOAc and n-BuOH fractions have the highest anti-oxidant activities compared to those of the other fractions [4].…”

Section: Resultssupporting

confidence: 92%

“…Flavonoids are polyphenolic compounds comprised of two benzene rings that are linked together with a heterocyclic pyran or pyrone ring [3]. This particular structure of flavonoids, combined with the position of its hydroxyl groups and the polarity of its glycoside derivatives, contributes to its anti-oxidant properties [4][5][6]. Flavonoids can also act as modulators of signaling pathways that are directly involved in cellular function and survival, such as the phosphoinositide 3kinase (PI3K), Akt/PKB, and MAPK pathways [7].…”

Section: Introductionmentioning

confidence: 99%

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Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

Lee

Quilantang

et al. 2019

JABC

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This study evaluated the anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata using 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydroxyl (OH) scavenging assays. The results showed that among the four fractions, the highest OH radical scavenging activity was exhibited by the n-butanol fraction. The DPPH radical scavenging activities of avicularin and isovitexin were higher than 50% at a concentration of 100 μg/mL. Moreover, one hundred micrograms per liter of avicularin and isovitexin exhibited effective anti-oxidant activity, with the OH radical scavenging rates being 87.54 and 91.48%, respectively. These results suggest that Lespedeza cuneata would be useful anti-oxidant agents from natural sources.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

Lee

Quilantang

et al. 2019

JABC

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“…Sericea lespedeza is known to have antioxidant properties that reduce free radical production [15]. In vitro studies using Lespedeza virgata have revealed presence of natural antioxidant properties in this species [16].…”

Section: Introductionmentioning

confidence: 99%

High-Condensed Tannin Diet and Transportation Stress in Goats: Effects on Physiological Responses, Gut Microbial Counts and Meat Quality

Batchu

Hazard

Lee

et al. 2021

Animals

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Feeding condensed tannin (CT)-containing diets such as sericea lespedeza (Lespedeza cuneata) and reducing stress have been reported to improve meat quality and food safety in goats. In a completely randomized design with split-plot, thirty-six uncastrated male Spanish goats were assigned to 3 dietary treatments (n = 12/treatment): ground ‘Serala’ sericea lespedeza hay (SER), bermudagrass (Cynodon dactylon) hay (BG), or bermudagrass hay—dewormed goats (BG-DW; Control) at 75% of intake, with a corn-based supplementation (25%) for 8 weeks. Prior to slaughter, goats were either transported for 90 min to impose stress or held in pens. Basophil counts were lower (p < 0.01) in the SER group compared to BG or BG-DW groups suggesting a better anti-inflammatory capacity due to polyphenols in the SER diet. Compared to BG-DW group, cortisol level was higher (p < 0.05) and norepinephrine was lower (p < 0.05) in the SER group. The SER group had the lowest aerobic plate counts (APC) in both rumen and rectum (p < 0.01). Longissimus dorsi muscle initial pH was not affected by diet or stress. Feeding sericea hay to goats may have beneficial effects, such as enhanced antioxidant and anti-inflammatory properties during stress and reduced gut microbial counts, without changing meat quality characteristics.

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“…In addition, the tannin-protein complexes that are formed when tannin-rich diets are fed to ruminants are reported to be harmful to gastrointestinal nematodes 7 . Sericea lespedeza (SL; Lespedeza cuneata ) is a perennial, drought tolerant legume that grows well on acidic soils with low fertility 8 and contains high concentration of CT. Sericea is known to have antioxidant properties that reduce free radical production 9 . In vitro studies using SL have revealed presence of natural antioxidant properties in this species 10 .…”

Section: Introductionmentioning

confidence: 99%

Plasma metabolomic profiles as affected by diet and stress in Spanish goats

Batchu

Terrill

Kouakou

et al. 2021

Sci Rep

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The effects of high-condensed tannin (CT) diet combined with preslaughter stress have not been studied at the metabolome level in goats. This study was conducted to determine the effects of feeding sericea lespedeza (SL; Lespedeza cuneata), a high-CT legume, and transportation stress on plasma metabolome in goats. Uncastrated male Spanish goats (age = 8 months; BW = 26.0 ± 0.48 kg) were either fed ground ‘Serala’ SL hay (SER), bermudagrass (Cynodon dactylon) hay (BG), or bermudagrass hay-dewormed goats (BG-DW; Control) at 75% of intake, with a corn-based supplementation (25%) for 8 weeks (n = 12/Diet). At the end of the trial, goats were subjected to one of two stress treatments (ST): transported for 90 min to impose stress (TS) or held in pens (NTS) before slaughtering, in two replicates. Live and carcass weights, and blood samples were collected at 0, 30, 60 and 90 min of transportation or holding time (Time). The data were analyzed using MIXED procedures in SAS and metabolomics data were analyzed using the R software. When measured after ST, SER group had the lowest body weight (P < 0.05) among the three diet groups. Carcass weights were high in the BG-DW, low in SER, and intermediate in BG group. Plasma creatine concentrations decreased over Time (P < 0.01) in the TS goats in all diet groups. Meat crude protein percentages were higher (P < 0.05) in SER (22.5 ± 0.22) and BG-DW (22.3 ± 0.22) groups compared to the BG group (21.6 ± 0.22). At the metabolome level, SER group had the lowest (P < 0.05) glycine, alanine, threonine, taurine, trans-hydroxyproline, methionine, and histidine concentrations and highest (P < 0.01) lysine and citrulline concentrations among the Diet groups. Butyric acid, concentration was higher (P < 0.05) in the SER group compared to BG group. Eight medium- and long-chained acylcarnitines were higher (P < 0.05) in the BG-DW group than SER or BG groups. In general, amino acid levels decreased and acylcarnitine increased with Time (P < 0.05) in all groups. Sericea diet can be beneficial in enhancing stress coping abilities in goats due to elevated butyrate, lysine, and citrulline levels; however, SER resulted in lower energy level in goats compared to BG or BG-DW groups. Fatty acid metabolism is the main energy pathway in all groups during prolonged stress. Inclusion of certain varieties of SL in the diet must be carefully controlled to prevent possible negative effect.

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Antioxidant and α-Glucosidase Inhibition Activities of Solvent Fractions from Methanolic Extract of Sericea Lespedeza (Lespedeza cuneata G. Don)

Cited by 13 publications

References 21 publications

Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

High-Condensed Tannin Diet and Transportation Stress in Goats: Effects on Physiological Responses, Gut Microbial Counts and Meat Quality

Plasma metabolomic profiles as affected by diet and stress in Spanish goats

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