Antioxidant and stabilization activity of a quercetin-containing flavonoid extract obtained from Bulgarian Sophora japonica L.

Mihaylova, Dasha; Schalow, Sebastian

doi:10.1590/s1516-89132013000300011

Cited by 25 publications

(18 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quercetin occurs abundantly in a variety of fruits and vegetables [2]. This biologically active compound exhibits remarkable antioxidant [3][4][5], anti-inflammatory [6], antibacterial [7,8], and anti-tumor [9] activities, and it possesses high anti-allergic activity [10]. However, quercetin is almost insoluble in water, sparingly soluble in gastrointestinal fluids, and it is metabolized by human intestinal bacteria [11,12].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

et al. 2020

View full text Add to dashboard Cite

The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several methods including scanning electron microscopy (SEM), IR spectroscopy, X-ray diffraction analysis (XRD), water contact angle measurements, differential scanning calorimetry (DSC), and UV-VIS spectroscopy were utilized to characterize the obtained materials. The incorporation of polyethylene glycol in the fibrous material resulted in increased hydrophilicity and burst release of quercetin from the fibers. Quercetin-containing fibrous mats exhibited high antioxidant activity as estimated by DPPH free radical scavenging method. In vitro tests with HeLa tumor cells and SH-4 melanoma skin cells were performed in order to determine the cytotoxicity of the novel materials. It was found that the fibrous CA/PEG/QUE materials exhibited high cytotoxic effect against both cell lines. Therefore, the novel polymeric materials containing quercetin are promising candidates for biomedical and pharmaceutical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Chia seeds contain several phenolic compounds which behave like antioxidants such as, caffeic acid, chlorogenic acid, myricetin, quercetin, and kaempferol [54]. Mihaylova and Schalow [55] revealed that high antioxidant properties were obtained by using quercetin in model food systems. The most important phenolic compounds present in chia seeds are caffeic and chlorogenic acids, which protect against free radicals and suppress peroxidation of fats, proteins, and DNA [5].…”

Section: Antioxidant Activity and Total Phenolic Contentmentioning

confidence: 99%

Chia Seed Mucilage Versus Guar Gum: Effects on Microstructural, Textural, and Antioxidative Properties of Set-Type Yoghurts

Atik

Demırcı

Öztürk

et al. 2020

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Texture is an important parameter which influences on the quality and acceptability of yoghurts. The utilize of stabilizers in yoghurt manufacturing has become a prevalent application to improve the textural properties of yoghurts. In this context, guar gum obtained from Cyamopsis tetragonolobus is generally used as a natural stabilizer for its thickening and gelling properties. Accordingly, this study evaluated the use of chia seed mucilage as an alternative to guar gum to improve the textural properties of yoghurt. This study focused on the effect of using chia seed mucilage (CSM) and guar gum (GG) at 1, 2, and 3% concentrations on the textural and microstructural characteristics of yoghurts. The results of fortifications with CSM and GG on the physicochemical, sensory, and antioxidative properties of yoghurts were also evaluated. Compared to GG, CSM provided higher antioxidant activity which improved with increasing concentrations of CSM. An enhancement was observed in textural properties of yoghurts containing CSM and GG, but CSM concentrations up to 2% gave better effect on firmness. Besides, the microstructure of yoghurt was enhanced depending on the increase in CSM and GG amounts. No negative effect was determined on the sensory properties of the samples by CSM and GG additions. The results showed that CSM can be used in set-type yoghurt production as an alternative stabilizer by improving firmness and consistency and reducing syneresis. Furthermore, its use is suitable for industrial yoghurt production with regards to sensorial properties.

show abstract

“…The mixture was incubated for 15 minutes at room temperature and protected from light. The scavenger action was observed by decreasing the absorbance at λ = 531 nm 17 .…”

Section: Dpph• Radical Scavenging Assaymentioning

confidence: 99%

A Simple and High-yield Synthesis of Hexadecyl Ferulate and Its In Vitro Antioxidant Potential

Nadal

Pedroso

Minozzo

et al. 2018

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Ferulic acid (FA) is a phenolic compound with well-known antioxidant potential that can be used as a promising anti-inflammatory and anti-cancer molecule. Furthermore, it has been reported to have neuroprotective activity. One of the main problems, which limit its clinical use, is its low bioavailability when administered orally. This limitation can be circumvented by changes in their structure and/or for preparing lipid-based formulations. The aim of this study was to synthesize a derivative of FA, the hexadecyl ferulate (HF). This compound would be more susceptible to pass through blood-brain barrier (BBB) due to its lipophilic character. The HF was obtained by Steglich esterification and yielded 76.77 ± 1.35%. Its structural characterization was performed by spectroscopic methods of Fourier-transformed infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). FTIR spectrum of HF presented two typical bands of ester group, a C=O ester stretching band at 1725 cm-1 and a CO stretching band at 1159 cm-1. The 1 H and 13 C spectral data confirmed the chemical structure of HF. Regarding the 13 C NMR spectrum, HF showed a chemical shift at δ 167.39 ppm which corresponded to the carbonyl carbon of the ester group. Concerning the in vitro antioxidant potential, HF had equivalent or improved scavenger activity than FA leading to IC50 values of 0.083 ± 0.009 nmol.mL-1 and 0.027 ± 0.002 nmol.mL-1 in DPPH radical scavenging and ABTS radical cation decolorization assays, respectively. Further studies are required in order to investigate the antioxidant effect of HF in biological media.

show abstract

Antioxidant and stabilization activity of a quercetin-containing flavonoid extract obtained from Bulgarian Sophora japonica L.

Abstract: This work aimed to study the antioxidant activity of a quercetin-containing flavonoid extract (QFЕ) obtained from

Cited by 25 publications

References 29 publications

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Chia Seed Mucilage Versus Guar Gum: Effects on Microstructural, Textural, and Antioxidative Properties of Set-Type Yoghurts

A Simple and High-yield Synthesis of Hexadecyl Ferulate and Its In Vitro Antioxidant Potential

Contact Info

Product

Resources

About