Antioxidant and Scavenging Activity of Emodin, Aloe-Emodin, and Rhein on Free-Radical and Reactive Oxygen Species

Vargas, Franklin; Díaz, Yrene; Carbonell, K.

doi:10.1080/13880200490519613

Cited by 41 publications

(33 citation statements)

References 24 publications

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“…7.0o d H o7.2). In addition, a 5,5 0 -linkage between the two emodin moieties forms the known skyrin, 13 which was likewise isolated from T. wortmanii in this study. Accordingly, the 7,7 0 -linkage of the emodin building blocks to form the new atropisomer 1 was unambiguously confirmed.…”

supporting

confidence: 52%

Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera

Bara

Aly

Pretsch³

et al. 2013

J Antibiot

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supporting

confidence: 52%

Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera

Bara

Aly

Pretsch³

et al. 2013

J Antibiot

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“…Our present study found that emodin glucuronides were the major molecules in blood after oral administration of emodin, whereas emodin glucuronides, ω‐OHE and ω‐OHE sulfates/glucuronides were present following intravenous administration. Given that previous in vitro studies reporting beneficial bioactivities of emodin all focused on emodin parent form,1–12 we therefore suspect whether the in vitro activities of emodin could predict its in vivo effects. Interestingly, as an extension of our pharmacokinetic study, we found that the effects of intravenous and oral metabolites of emodin against AAPH‐induced hemolysis were more effective than emodin.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past two decades, the free radical‐mediated peroxidation of membrane lipid and oxidative damage of DNA was believed to be associated with a variety of health problems, such as cancer, atherosclerosis, neurodegenerative diseases and aging. Previous studies have reported promising in vitro antioxidation activity of emodin,1, 2 nevertheless, the in vitro efficacy of emodin remained to be explored. As an extension of our pharmacokinetic study, the serum metabolites of emodin after intravenous and oral administrations were obtained from rats and characterized.…”

Section: Introductionmentioning

confidence: 99%

“…ex B ALF , Rheum officinal B AILL and Polygonum cuspidatum S IEB and Z UCC . Various in vitro beneficial activities of emodin, including antioxidation,1, 2 anti‐inflammation,3, 4 anti‐angiogenesis5, 6 and anticancer7–12 have been reported. However, whether the in vitro findings can predict in vivo effects of emodin remained an unanswered question for the lack of understanding the metabolism and pharmacokinetics of emodin in animals.…”

Section: Introductionmentioning

confidence: 99%

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External validation of FIB-4: Diagnostic accuracy is limited in elderly populations

Kurosaki

Izumi

2007

Hepatology

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We read with interest the articles by Stering et al. 1 and ValletPichard et al. 2 The former authors developed the FIB-4 index, a noninvasive method for assessing liver fibrosis in patients with HIV/HCV coinfection. The variables used are age, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and platelet (PLT) count, and the formula is as follows:). They showed that over 70% of patients could be classified into either absence or presence of advanced fibrosis by cutoff of Ͻ1.45 or Ͼ3.25 respectively, with diagnostic accuracy of 87%. The latter authors expanded the applicability of the FIB-4 index to HCVmonoinfected patients and showed that 73% of patients were classified with diagnostic accuracy of 93%, an excellent performance in both classification and accuracy of diagnosis.Because the mean age of patients was young in these studies (40 years 1 and 44 years 2 ), we wondered whether this index could also fit to Japanese patients who are rather older than the Western patients. We validated the FIB-4 index in a retrospective cohort of 1,405 patients who underwent liver biopsy at our hospital. The mean age was 55 Ϯ 12 years. The distribution of METAVIR fibrosis scores was as follows: 1.6% showed no fibrosis (F0), 44.8% showed mild fibrosis (F1), 29.5% showed moderate fibrosis (F2), 20.2% showed severe fibrosis (F3), and 3.9% showed cirrhosis (F4). The proportion of advanced fibrosis (F3 or F4) was slightly higher in our population compared to the former studies (24.1% vs. 20.7% 1 and 17.2% 2 ). As shown in Table 1, only 53% of patients were classified to either Ͻ1.45 or Ͼ3.25, a much lower rate than previous reports. The diagnostic accuracy was excellent in patients with a FIB-4 index Ͻ1.45 (94%), however, it was relatively poor in patients with a FIB-4 index Ͼ3.25 (50%) making the overall accuracy as low as 67%.We supposed this discordance with previous reports may be derived from the older age of our populations and thus we categorized patients into three groups according to age and analyzed separately. In patients with age Յ50 years, 64% of patients were classified, and the diagnostic accuracy was 94% for a FIB-4 index Ͻ1.45 and 68% for a FIB-4 index Ͼ3.25 making the overall accuracy of 90%, a result comparable to previous reports. In older patients, however, diagnostic accuracy was significantly low compared to those with age Յ50 years (56% for age 51-60 years, P Ͻ 0.0001 and 51% for age Ն60 years, P Ͻ 0.0001). Because patients with a FIB-4 index Ͼ3.25 increased according to age (6%, 34%, and 53% for ages Յ50, 51-60 and Ͼ60 years), and the diagnostic accuracy was low in these patients (48% to 50%), these results suggest that, in elderly patients, a variable "age" generates excessively high FIB-4 index leading to misclassification of no-moderate fibrosis (F0-F2) into a FIB-4 index Ͼ3.25.In conclusion, the FIB-4 index could accurately differentiate advanced fibrosis in young Japanese patients with chronic hepatitis C but the diagnostic accuracy is limited in the elderly. Thus, in elderly patients,...

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“…Later, Beppu et al, (57) reported the oxygen scavenging activity of the two phenolic compounds (2'-O-p-coumaroylaloesin and 2'-O-feruloylaloesin), preventing thus the destruction of the pancreatic islets. The antioxidant activity of aloeemodin depends also on scavenging hydroxyl radicals (58,59). Moreover, it appears that the antioxidant or pro-oxidant activity of aloe-emodin is related to its concentration (60).…”

Section: Antioxidant Activitymentioning

confidence: 98%

Biology and Chemistry of the Genus Aloe from Africa

Koroch¹,

Juliani²,

Simon³

2009

ACS Symposium Series

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Aloe is a medicinal plant that has been used since ancient times by cultures in many countries and continents for many of the same applications. Africa is blessed with a wide variety of Aloe spp. each used by the indigenous cultures. Fleshy leaves are the source of two of the main products, gel and latex, with both products showing distinct differences in their chemical composition. Chemical composition of gel consists mainly of water with carbohydrate polymers and a range of other organic and inorganic components. In contrast, the chemical composition of the latex includes many phenolic compounds such as anthraquinones and chromones. The objective of this paper is to review the the botany, chemistry and pharmacological properties of Aloes from Africa.

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Antioxidant and Scavenging Activity of Emodin, Aloe-Emodin, and Rhein on Free-Radical and Reactive Oxygen Species

Cited by 41 publications

References 24 publications

Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera

Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera

External validation of FIB-4: Diagnostic accuracy is limited in elderly populations

Biology and Chemistry of the Genus Aloe from Africa

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