Antioxidant and Renin-Angiotensin System Inhibitory Properties of Cashew Nut and Fluted-Pumpkin Protein Hydrolysates

Malomo, Sunday A.; Nwachukwu, Ifeanyi D.; Girgih, Abraham T.; Idowu, Atinuke O.; Aluko, Rotimi E.; Fagbemi, Tayo Nathaniel

doi:10.31883/pjfns/122460

Cited by 19 publications

(39 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, highly nutritious diets with rich amino acid contents, such as arginine, tyrosine/phenylalanine and valine/leucine, have the capacity of fighting against the chronic cardiovascular diseases. For instance, arginine, aromatic and branched-chain amino acids have been extensively reported for their health beneficial effects such as, antioxidant (Malomo et al 2020), antihypertensive (Poggiogalle et al 2019) and adequate combating agents towards protein-energy malnutrition commonly associated with growing children (Arise et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Nutritional quality of formulated complementary diet from defatted almond seed, yellow maize and quality protein maize flours

Adesanmi

Malomo

Fagbemi

2020

Food Prod Process and Nutr

View full text Add to dashboard Cite

Traditional complementary foods are mainly starchy foods with limiting nutrient quality and can be fortified using protein rich crops like almond seed. This research thus aimed at investigating the nutritional quality of the formulated complementary diet from locally available almond seeds (Prunus amygdalus), high quality protein (QPM) and yellow maize after blending into flours. The proximate and amino acid compositions, in vitro protein qualities and functional properties of the blended flours were determined using standard methods. The in vivo studies involved feeding the weanling Wister albino rats with blended flours and commercial Cerelac (control), followed by hematological and histopathological determinations, while sensory attributes were evaluated by the semi-trained panelists. The protein contents of the flour blends (24–28%) were significantly (p < 0.05) better with adequate indispensable amino acids and improved functionalities than commercial cerelac (23%). Comparatively, the dried germinated QPM (DGQPM) has significant (p < 0.05) higher biological value (~ 37%) than fermented high QPM (FHQPM) (~ 30%), thereby indicating that the germination process improved protein quality of the diets. Besides, the in vivo data showed a positive effect of germination process as the rats fed with DGQPM has low white blood cells (30 × 102) compared to FHQPM (42 × 102) and cerelac (51 × 102). However, the fermentation process improved the packed cell volume of rats fed with FHQPM (49%) when compared to DGQPM and cerelac (47%). The formulated diets have no negative effects on the protein content (45.19–51.88 mg N/g) and weight (0.25–1.36 g) of the internal organs (liver, kidney and tissue) of the animals when compared to cerelac (53.72–55.04 mg N/g; 0.25–1.98 g), respectively. The panelists generally accepted all the formulated diets, hence encouraging their utilization in the global preparation of complimentary foods for young children to meet their nutritional needs and adding value to the locally produced underutilized almond seeds.

show abstract

Section: Introductionmentioning

confidence: 99%

Nutritional quality of formulated complementary diet from defatted almond seed, yellow maize and quality protein maize flours

Adesanmi

Malomo

Fagbemi

2020

Food Prod Process and Nutr

View full text Add to dashboard Cite

show abstract

“…The values obtained for DH showed that pancreatin was the most efficient in the hydrolysis of globulin fractions of Anarcardium occidentale nut protein isolate. Variation in degree of hydrolysis was probably due to protease specificity; higher degree of hydrolysis by pancreatin may be due to the fact that it contains aromatic and cationic amino acids contents in the cashew nut protein for which pancreatin has broad specificity ( Malomo et al., 2020 ). The low DH obtained for tryptic CNPH might be due to the limited amount of peptide linkages present in cashew nut for which trypsin have high specificity.…”

Section: Discussionmentioning

confidence: 99%

“…The cashew nuts were cut into pieces, dried, dehulled, pulverized, defatted and grounded into flour according to the method of Malomo et al. (2020) .…”

Section: Methodsmentioning

confidence: 99%

“…The cashew nuts were cut into pieces, dried, dehulled, pulverized, defatted and grounded into flour according to the method of Malomo et al (2020). It was sieved and stored in a plastic container at -20 C. Its protein component was extracted using the method of Arise et al (2019).…”

Section: Isolation Fractionation Purification and Characterization mentioning

confidence: 99%

“…Proteins in seeds can been developed into valuable nutraceutics. Food-based peptides are attracting attention owning to their antioxidants, α-amylase and renin-angiotensin system inhibitory activities, hence they are of considerable food and economic importance in managing diabetes and hypertension ( WHO, 2019 ; Saadi et al, 2015 ; Arise et al, 2019a ; Malomo et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Blood pressure and sugar regulating potentials of Anarcadium occidentale nut globulin and albumin hydrolysates

Arise

Taofeek

Babaita

et al. 2021

Heliyon

View full text Add to dashboard Cite

Several novel functional peptides have been successfully extracted from plant storage proteins. This study investigated the degree of hydrolysis, peptide yield, amino acid constituents, angiotensin converting enzyme (ACE), alpha amylase inhibitory and in vitro antioxidant activities of cashew (Anarcardium occidentale) nut proteins (CNP) hydrolysates (CNPHs). Cashew nut proteins (albumin and globulin) were hydrolysed using pancreatin, Alcalase and trypsin. The peptide yield and degree of hydrolysis (DH) of CNP by pancreatin (75.69 AE 0.84%; 37.39 AE 0.31) was significantly higher than those by Alcalase (61.67 AE 0.55%; 23.87 AE 0.23) and trypsin (43.33 AE 0.45%; 11 AE 0.15). The inhibition of ACE by albumin and globulin hydrolysates was concentration dependent. At 1.2 mg/mL, ACE-inhibitory activity of pancreatic cashew nut globulin (CNGH) hydrolysate (51.65 AE 1.2%) was significantly higher than those of Alcalase (34.603 AE 0.65%) and tryptic (29.92 AE 0.73%) CNGHs. Cashew nut albumin hydrolysate (CNAH) demonstrated concentration-dependent alpha-amylase inhibition (IC 50 0.17 AE 0.02-0.41 AE 0.021 mg/mL). The order of inhibition was tryptic > Alcalase > pancreatic CNAHs. The pancreatic hydrolysates of both albumin and globulin fractions displayed the highest DPPH antioxidant activity, while pancreatic CNAH was the most potent superoxide anion scavenger. These findings therefore posit that cashew nut globulin and albumin hydrolysates are laden with useful bioactive peptides that may be further explored for regulation of blood pressure and sugar in hypertensive and diabetic in vivo models.

show abstract

Biorefinery of Cashew By-Products: Recovery of Value-Added Compounds

Silva

Brito

Ferreira

2022

Food Bioprocess Technol

View full text Add to dashboard Cite

Antioxidant and Renin-Angiotensin System Inhibitory Properties of Cashew Nut and Fluted-Pumpkin Protein Hydrolysates

Cited by 19 publications

References 53 publications

Nutritional quality of formulated complementary diet from defatted almond seed, yellow maize and quality protein maize flours

Nutritional quality of formulated complementary diet from defatted almond seed, yellow maize and quality protein maize flours

Blood pressure and sugar regulating potentials of Anarcadium occidentale nut globulin and albumin hydrolysates

Biorefinery of Cashew By-Products: Recovery of Value-Added Compounds

Contact Info

Product

Resources

About