Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Roy, Sanjeev; Sehgal, Rachna; Padhy, Biswa Mohan; Kumar, Vijay

doi:10.1016/j.jep.2005.06.026

Cited by 117 publications

(83 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Improvement in locomotor functions by other antiinflammatory agents has also been reported earlier (Selph et al, 1993). Like other antiinflammatory agents the efficacy of latex as an antiarthritic agent could also be attributed to its antioxidant properties (Schinella et al, 2002;Roy et al, 2005).…”

Section: Effect Of DL and Medl On Stair Climbing Abilitymentioning

confidence: 58%

“…Traditionally the fresh or warmed leaves have been applied on painful rheumatic joints, swellings, sores and wounds (Wealth of India, 1992). The plant has also been found to possess a number of biological activities namely, proteolytic, antimicrobial, antioxidant, antisecretory and anticancer (Atal and Sethi, 1962;Malik and Chaughati, 1979;Roy et al, 2005;Kumar and Shivkar, 2004;Ayoub and Kingston, 1981). Experimentally, the extracts of its roots and dried latex (DL) have been reported to exhibit potent analgesic and antiinflammatory properties (Dewan et al, 2000;Kumar and Basu, 1994).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Kumar

Roy

2008

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

The protective effect of latex of Calotropis procera in Freund's Complete Adjuvant (FCA) induced monoarticular arthritis was evaluated in rats. Arthritis was induced by a single intra-articular injection of 0.1 mL of 0.1% FCA in the right ankle joint. The effect of dried latex (DL, 200 and 400 mg/ kg) and its methanol extract (MeDL, 50 and 500 mg/ kg) following oral administration was evaluated on joint inflammation, hyperalgesia, locomotor function and histology at the time of peak inflammation. The effects of DL and MeDL were compared with antiinflammatory drugs phenylbutazone (100 mg/ kg), prednisolone (20 mg/kg), rofecoxib (20 and 100 mg/ kg) and immuno-suppressant methotrexate (0.3 mg/ kg). Daily oral administration of DL and its methanol extract (MeDL) produced a significant reduction in joint inflammation (about 50% and 80% inhibition) and associated hyperalgesia. The antihyperalgesic effect of MeDL was comparable to that of rofecoxib. Both DL and MeDL produced a marked improvement in the motility and stair climbing ability of the rats. The histological analysis of the arthritic joint also revealed significant reduction in oedema and cellular infiltration by MeDL that was comparable to that of rofecoxib. Thus, our study suggests that the latex of C. procera has the potential to be used as an antiarthritic agent.

show abstract

Section: Effect Of DL and Medl On Stair Climbing Abilitymentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Kumar

Roy

2008

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…The plant has also antimicrobial (Malik & Chaughati, 1979), antioxidant (Roy et al, 2005), anticancer (Ayoub & Kingston, 1981) and anthelmintic activities (Al-Qarawi et al, 2001;Iqbal et al, 2005). Experimentally, an ethanol extract of C. procera flowers was reported to have antipyretic, analgesic (Mascolo et al, 1988), anticancerogenic (Smit et al, 1995), antimalarial (Sharma & Sharma, 1999) and hepatoprotective (Qureshi et al, 2007) activities.…”

Section: Introductionmentioning

confidence: 99%

“…The milky white latex of this plant has been reported to exhibit potent anti-inflammatory and analgesic, and weak antipyretic activities in various experimental models (Dewan et al, 2000;Kumar & Basu, 1994;Kumar & Arya, 2006). It has also been demonstrated to possess antioxidant, antihyperglycemic and hepatoprotective properties (Padhy et al, 2007;Roy et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Potential effect of the medicinal plantsCalotropis procera. Ficus elasticaandZingiber officinaleagainstSchistosoma mansoniin mice

el-Din¹,

El-Lakkany²,

Mohamed

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 AE 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z. officinale-treated group) similarly treated as the first batch in addition to the antacid ranitidine (30 mg/kg) 1 h before extract administration. Safety, worm recovery, tissues egg load and oogram pattern were assessed. Results: Calotropis procera latex and flower extracts are toxic (50-70% mortality) even in a small dose (250 mg/kg) before washing off their toxic rubber. Zingiber officinale extract insignificantly decrease (7.26%) S. mansoni worms. When toxic rubber was washed off and ranitidine was used, C. procera (stem latex and flowers) and F. elastica extracts revealed significant S. mansoni worm reductions by 45.31, 53.7 and 16.71%, respectively. Moreover, C. procera extracts produced significant reductions in tissue egg load ($34-38.5%) and positively affected oogram pattern. Conclusion:The present study may be useful to supplement information with regard to C. procera and F. elastica antischistosomal activity and provide a basis for further experimental trials.

show abstract

“…It also used to improve digestion, increase appetite and enlargements of abdominal viscera. Latex of the plant was reported to possess analgesic activity , anti-inflammatory activity (Singh et al, 2000), anti-oxidant activity (Roy et al, 2005), antidiarrhoeal activity (Kumar et al, 2001), antinociceptive activity (Soares et al, 2005) and antimalarial activity (Sharma and Sharma, 2000). Roots are reported for antifertility activity (Kamath and Rana, 2002), antitumor activity (Mathur et al, 2009) and anticonvulsant activity (Jalalpure et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of Calotropis procera against Culex tritaeniorhynchus and Culex gelidus

Kumar

Karthik

Rao

et al. 2012

Bangladesh J Pharmacol

View full text Add to dashboard Cite

Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats

Cited by 117 publications

References 25 publications

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Protective effect of latex of Calotropis procera in Freund's Complete Adjuvant induced monoarthritis

Potential effect of the medicinal plantsCalotropis procera. Ficus elasticaandZingiber officinaleagainstSchistosoma mansoniin mice

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of <i>Calotropis procera </i> against <i>Culex tritaeniorhynchus</i> and <i>Culex gelidus</i>

Contact Info

Product

Resources

About