Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid

Yen, Gow‐Chin; Duh, Pin-Der; Tsai, H.-E.

doi:10.1016/s0308-8146(02)00145-0

Cited by 518 publications

(303 citation statements)

References 18 publications

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“…On the other hand, meat from the animals receiving GA had a lower TBA-RS index. High antioxidant activity of GA was also found by Yen et al (2002). Fat extracted from this meat had a higher PUFA content too.…”

Section: Resultssupporting

confidence: 55%

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Gallic acid or sage extract supplement in feed mixtures for finishing pigs

Hańczakowska¹,

Świątkiewicz²

2005

J. Anim. Feed Sci.

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The effects of supplementing mixtures for 42 fattening pigs (60-113 kg of body weight) with gallic acid, GA, (50 mg kg -1 ) or sage extract, SE, (800 mg kg -1 of mixture) on fattening results, meat quality and oxidative stability were investigated. The supplements had no effect on body weight gains. Pigs receiving GA deposited significantly less meat and more fat but GA was a better antioxidant than SE. After 6 months of storage, TBA-RS in meat of GA pigs were significantly lower than in controls. GA also significantly lowered the cholesterol level in meat. The sage extract supplement distinctly increased meatiness and loin eye area when compared with the GA group.

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Section: Resultssupporting

confidence: 55%

“…Gallic acid, a tannin hydrolysis product, is common in plants (knotgrass, billberry). Its antioxidant activity is comparable to that of ascorbic acid (Yen et al, 2002). Due to this activity phenolics can improve the oxidative stability of fat (Gu and Weng, 2001).…”

Section: Introductionmentioning

confidence: 93%

Gallic acid or sage extract supplement in feed mixtures for finishing pigs

Hańczakowska¹,

Świątkiewicz²

2005

J. Anim. Feed Sci.

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“…DFO and ascorbic acid were used in ROS studies as controls due to their scavenging and metal chelating activities. 39,40 ROS amounts were significantly reduced with both DFO and ascorbic acid compared to positive control. In the literature, there are many studies showing that both extract of natural compounds and single polyphenolic compounds decrease intracellular ROS amount and protect biomolecules from oxidative stress.…”

mentioning

confidence: 87%

“…23 Yen et al reported that ascorbic and gallic acid prevents H 2 O 2 -induced oxidative damage in lymphocytes through decreasing DNA damage with their radical scavenging activity. 40 Wang et al reported that caffeic acid phenethyl ester (CAPE) and its derivatives prevent endothelial cells against menadione-induced oxidative damage. 43 In another study, Song et al demonstrated that CAPE prevent H 2 O 2 -induced oxidative stress in human middle ear epithelial cells due to decreasing intracellular ROS.…”

mentioning

confidence: 99%

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Mısır¹,

Aliyazıcıoğlu²,

Demir³

et al. 2018

IJPER

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Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H 2 DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.

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“…EGCG contains multiple hydroxyl groups, particularly in the B-rings, and it significantly increases the production of ROS. High dosages of EGCG can induce DNA damage [41,103,124] due to the generation of hydrogen peroxide. A recent study showed that EGCG neither directly scavenges hydrogen peroxide nor mediates other antioxidant activities, but instead increases hydrogen-peroxide-induced oxidative stress and DNA damage in vitro [19].…”

Section: Possible Prooxidant Activity and Carcinogenicity Of Some Polmentioning

confidence: 99%

The roles of polyphenols in cancer chemoprevention

2006

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Abstract.Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative diseases. The ROS-induced development of cancer involves malignant transformation due to altered gene expression through epigenetic mechanisms as well as DNA mutations. Considerable attention has been focused on identifying naturally occurring antioxidative phenolic phytochemicals that are able to decrease ROS levels, but the efficacies of antioxidant therapies have been equivocal at best. Several studies have shown that some antioxidants exhibit prooxidant activity under certain conditions and potential carcinogenicity under others, and that dietary supplementation with large amounts of a single antioxidant may be deleterious to human health. This article reviews the intracellular signaling pathways that respond to oxidative stress and how they are modulated by naturally occurring polyphenols. The possible toxicity and carcinogenicity of polyphenols is also discussed.

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Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid

Cited by 518 publications

References 18 publications

Gallic acid or sage extract supplement in feed mixtures for finishing pigs

Gallic acid or sage extract supplement in feed mixtures for finishing pigs

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

The roles of polyphenols in cancer chemoprevention

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