Antioxidant and pro-oxidant phytochemicals in ultrasound and microwave assisted extracts from hop cones: a statistical modelling approach

Ramazzina, Ileana; Macchioni, Valentina; Carbone, Katya

doi:10.1039/d2fo02020c

Cited by 3 publications

(5 citation statements)

References 36 publications

(56 reference statements)

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“…They can also exert an important antioxidant action, particularly against the hydroperoxide radical [93]. Recently, Macchioni et al (2022) reported that ethanolic extracts from freeze-dried hop leaves exhibited a total chlorophyll content in line with the average content of green tea leaves (1.47 mg/g) [93]. In addition, the supercritical CO 2 extract from hop pellets (cv.…”

Section: Nonphenolic Pigmentsmentioning

confidence: 87%

“…The authors highlighted the role of the extraction process and the chosen solvent on the biological properties of hop extracts towards target cells, explaining the observed in terms of the inhibitor-promoter pair using chemometric models. The results demonstrated the crucial role of molecules such as ferulic acid (promoting)-adlupolone (inhibitor), and coumaric acid (promoting) + protocatechuic acid (inhibitor), respectively [128].…”

Section: Antitumour Activitymentioning

confidence: 92%

“…Results indicated that XN effectively induced the upregulation of the c-Jun N-terminal kinase in the mitogen-activated protein kinase, promoting the apoptosis of NPC [44]. Recently, several authors have also suggested that the anticancer properties of XN may be due to its prooxidant activity, as it is able to induce ROS generation through NADPH oxidase in a dose-dependent manner [126][127][128]. Blanquer-Rossellò et al (2013) found that XN increased ROS levels in breast cancer cells by improving mitochondrial function at high concentrations [43].…”

Section: Antitumour Activitymentioning

confidence: 99%

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An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Carbone

Gervasi

2022

Plants

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The medicinal potential of hop (Humulus lupulus L.) is widely cited in ancient literature and is also allowed in several official pharmacopoeias for the treatment of a variety of ailments, mainly related to anxiety states. This is due to the plethora of phytoconstituents (e.g., bitter acids, polyphenols, prenyl flavonoids) present in the female inflorescences, commonly known as cones or strobili, endowed with anti-inflammatory, antioxidant, antimicrobial, and phytoestrogen activities. Hop has recently attracted the interest of the scientific community due to the presence of xanthohumol, whose strong anti-cancer activity against various types of cancer cells has been well documented, and for the presence of 8-prenyl naringenin, the most potent known phytoestrogen. Studies in the literature have also shown that hop compounds can hinder numerous signalling pathways, including ERK1/2 phosphorylation, regulation of AP-1 activity, PI3K-Akt, and nuclear factor NF-κB, which are the main targets of the antiproliferative action of bitter acids and prenylflavonoids. In light of these considerations, the aim of this review was to provide an up-to-date overview of the main biologically active compounds found in hops, as well as their in vitro and in vivo applications for human health and disease prevention. To this end, a quantitative literature analysis approach was used, using VOSviewer software to extract and process Scopus bibliometric data. In addition, data on the pharmacokinetics of bioactive hop compounds and clinical studies in the literature were analysed. To make the information more complete, studies on the beneficial properties of the other two species belonging to the genus Humulus, H. japonicus and H. yunnanensis, were also reviewed for the first time.

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Section: Nonphenolic Pigmentsmentioning

confidence: 87%

Section: Antitumour Activitymentioning

confidence: 92%

Section: Antitumour Activitymentioning

confidence: 99%

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An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Carbone

Gervasi

2022

Plants

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“…These extraction methods, including steam distillation, hydro distillation, and liquid-solvent extraction, require high temperatures, long processing times, and at times many extraction steps, limited extraction efficiency, safety issues, and environmental concerns regarding the use of toxic solvents [19][20][21][22][23][24]. Recently, green, and non-thermal alternatives such as ultrasounds, pressurized liquids, supercritical fluid extraction, pulsed electric fields, and cold plasma (CP) have been introduced to partially overcome these problems [7,[25][26][27][28]. These new methods can reduce energy consumption, process time, use of organic solvents, and loss of nutrient/nutraceutical compounds, enabling high-quality functional plant extracts [14,[29][30][31].…”

Section: Phytochemical Classmentioning

confidence: 99%

Cold Plasma-Assisted Extraction of Phytochemicals: A Review

Heydari,

Carbone,

Gervasi

et al. 2023

Foods

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In recent years, there has been growing interest in bioactive plant compounds for their beneficial effects on health and for their potential in reducing the risk of developing certain diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. The extraction techniques conventionally used to obtain these phytocompounds, however, due to the use of toxic solvents and high temperatures, tend to be supplanted by innovative and unconventional techniques, in line with the demand for environmental and economic sustainability of new chemical processes. Among non-thermal technologies, cold plasma (CP), which has been successfully used for some years in the food industry as a treatment to improve food shelf life, seems to be one of the most promising solutions in green extraction processes. CP is characterized by its low environmental impact, low cost, and better extraction yield of phytochemicals, saving time, energy, and solvents compared with other classical extraction processes. In light of these considerations, this review aims to provide an overview of the potential and critical issues related to the use of CP in the extraction of phytochemicals, particularly polyphenols and essential oils. To review the current knowledge status and future insights of CP in this sector, a bibliometric study, providing quantitative information on the research activity based on the available published scientific literature, was carried out by the VOSviewer software (v. 1.6.18). Scientometric analysis has seen an increase in scientific studies over the past two years, underlining the growing interest of the scientific community in this natural substance extraction technique. The literature studies analyzed have shown that, in general, the use of CP was able to increase the yield of essential oil and polyphenols. Furthermore, the composition of the phytoextract obtained with CP would appear to be influenced by process parameters such as intensity (power and voltage), treatment time, and the working gas used. In general, the studies analyzed showed that the best yields in terms of total polyphenols and the antioxidant and antimicrobial properties of the phytoextracts were obtained using mild process conditions and nitrogen as the working gas. The use of CP as a non-conventional extraction technique is very recent, and further studies are needed to better understand the optimal process conditions to be adopted, and above all, in-depth studies are needed to better understand the mechanisms of plasma–plant matrix interaction to verify the possibility of any side reactions that could generate, in a highly oxidative environment, potentially hazardous substances, which would limit the exploitation of this technique at the industrial level.

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“…Medicinal and aromatic plants (MAPs) are plants or portions thereof used primarily for their medicinal or aromatic properties in pharmaceutical, nutraceutical, phytotherapeutical, cosmeceutical, etc., industries [1]. This is due to the multitude of biologically active secondary metabolites present in these plants, which allow them to be formulated into a wide range of commercial products [2], to the extent that these species are globally considered an important source of income for farmers in rural areas, fostering enormous trade from the local to the international level [3]. World trade in MAP resources is expected to grow annually at a rate of between 10 and 12%, driven by the phytotherapy sector, whose sales, according to Future Market Insights, will approach USD 500 billion by 2033, with a growth rate of around (%) over the forecast period [4].…”

Section: Introductionmentioning

confidence: 99%

Farming of Medicinal and Aromatic Plants in Italy: Structural Features and Economic Results

Macaluso,

Licciardo,

Carbone

2024

Agriculture

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In recent years, the primary sector in Italy and elsewhere has been profoundly affected by climate change and a deep economic crisis, mainly linked to stagnating prices and rising production costs. Because of this situation, we are witnessing renewed interest in alternative agricultural productions, which are characterized by their resilience and sustainability, including medicinal and aromatic plants (MAPs). This sector is characterized by a certain heterogeneity due to the great variety of species and their wide range of uses. Although these characteristics contribute to the sector’s economic success, they also hinder its study due to commodity complexity and limited data availability. At the farm level, the situation is complicated by the fact that MAP cultivation is often embedded in complex cropping systems, and more rarely, is practiced exclusively or predominantly. In light of these considerations, we concentrated solely on the agricultural phase of the supply chain, using data available in the Farm Accountancy Data Network. We aimed to examine the main structural characteristics and economic outcomes of Italian farms that grow MAP, as well as the profitability of some of the species. To ensure accurate species classification, only MAPs exclusively designated for botanical use in the Italian National List were considered. The analysis of farm economic performance indicators (gross output, variable costs, gross margins, etc.) focused mainly on the species most represented in the sample: saffron, rosemary, lavender, oregano, and sage. The results indicate that the total gross output and gross margin show the best performance in the case of saffron (66,200 and 57,600 EUR/ha, respectively) and rosemary (27,500 and 22,000 EUR/ha, respectively). However, for saffron, the biggest cost concerns propagation (purchase of bulbs), amounting to 50% of the variable costs, whereas fertilization ones are particularly high for sage and rosemary.

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Antioxidant and pro-oxidant phytochemicals in ultrasound and microwave assisted extracts from hop cones: a statistical modelling approach

Abstract: The present study investigated the relationships between different green extracts from hop cones (HGEs) and their cytoprotective/cytotoxic effects on human cultured colonocytes, using a multivariate statistical approach.

Cited by 3 publications

References 36 publications

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Cold Plasma-Assisted Extraction of Phytochemicals: A Review

Farming of Medicinal and Aromatic Plants in Italy: Structural Features and Economic Results

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