Antioxidant and pro-oxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells

Yeh, Shu-Lan; Hu, Miao‐Lin

doi:10.1016/s0955-2863(00)00117-0

Cited by 85 publications

(48 citation statements)

References 37 publications

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“…On the other hand, the survival capacity of E. coli containing only pACCRT-EB or pET28I receiving the same treatment with IPTG was not affected. Pro-oxidant actions of lycopene have also been reported in other biological systems (Lowe et al, 1999;Yeh & Hu, 2000). The antioxidant activity of some carotenoids may shift into pro-oxidant activity, depending on their concentrations as well as on the biological environment including oxygen tension (Palozza, 1998).…”

Section: Discussionmentioning

confidence: 89%

Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans

Teng

Sun

et al. 2007

Microbiology

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The phytoene-related desaturases are the key enzymes in the carotenoid biosynthetic pathway. The gene encoding phytoene desaturase in the deinoxanthin synthesis pathway of Deinococcus radiodurans was identified and characterized. Two putative phytoene desaturase homologues (DR0861 and DR0810) were identified by analysis of conserved amino acid regions, and the former displayed the highest identity (68 %) with phytoene desaturase of the cyanobacterium Gloeobacter violaceus. DR0861 gene knockout and dinucleotide-binding motif deletion resulted in the arrest of lycopene synthesis and the accumulation of phytoene. The colourless DR0861 knockout mutant became more sensitive to acute ionizing radiation and oxygen stress. Complementation of the mutant with a heterologous or homologous gene restored its pigment and resistance. The desaturase activity of DR0861 (crtI) was further confirmed by the assay of enzyme activity in vitro and heterologous expression in Escherichia coli containing crtE and crtB genes (responsible for phytoene synthesis) from Erwinia uredovora. In addition, the amount of lycopene synthesis in E. coli resulting from the expression of crtI from D. radiodurans was determined, and this had significant dose-dependent effects on the survival rate of E. coli exposed to hydrogen peroxide and ionizing radiation.

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Section: Discussionmentioning

confidence: 89%

Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans

Teng

Sun

et al. 2007

Microbiology

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“…The health benefits of tomatoes are probably attributed to lycopene, which has a similar structure to the antioxidant β-carotene. Yeh and Hu (2000) reported that lycopene and β-carotene behave similarly under in vitro oxidative conditions. Srinivasan et al (2007) reported that lycopene offers protection against gamma radiation damage.…”

Section: Discussionmentioning

confidence: 99%

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Sun¹,

Ma²,

Zhang³

et al. 2014

Czech J. Anim. Sci.

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ABSTRACT:Lycopene is a carotenoid present in vegetables and ripe fruit and has been proved to be the most potent antioxidant among various common carotenoids. This study assessed the effects of lycopene on performance production, tissue lycopene content, antioxidant capacity, and biochemical parameters in 720 Xing-hua breeding hens. Rice-soybean diets were supplemented with different lycopene levels: 0, 20, 40, and 80 mg/kg. Lycopene supplementation significantly increased fertilization rates in hens. Serum and egg lycopene contents and the Roche Yolk Colour Fan score increased with lycopene supplementation through day 7. In the liver, lycopene supplementation significantly increased superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and reduced glutathione to oxidized glutathione ratio (GSH/GSSG). Additionally, lycopene supplementation increased serum SOD, serum T-AOC, serum glutathione peroxidase, and serum GSH/GSSG. Lycopene addition significantly decreased total cholesterol and increased high density lipoprotein cholesterol and triiodothyroxine. It also improved fertilization rates, antioxidant capacity, and metabolism in breeding hens.

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“…The hepatoprotective effect of F. angustifolia ethanol extracts against paracetamol-induced toxicity was investigated using the method of Yeh and Hu (21). Forty male albino mice (25 ± 2 g) were randomly allocated to control and test groups (n = 8) in the following manner: group I (negative control) received saline solution (0.9%); group II (positive control) received an oral overdose of paracetamol (10 g/60 kg) on day 1 and serum saline (0.9%) on days 2 and 3; groups III, IV, and V were administered paracetamol (10 g/60 kg) on day 1 and FAL (50 mg/kg), FAB (50 mg/kg), and a mixture of both (25 mg/kg of each), respectively, on days 2 and 3.…”

Section: Hepatoprotective Potentialmentioning

confidence: 99%

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

et al. 2016

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Antioxidant and pro-oxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells

Cited by 85 publications

References 37 publications

Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans

Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

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