Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer

Bolajoko, Elizabeth Bosede; Mossanda, KenseseE Sontin; Adeniyi, F. A. A.; Akinosun, Olubayo Michael; Fasanmade, Adesoji Adedipe; Moropane, Mpho

doi:10.1080/22201009.2008.10872171

Cited by 21 publications

(2 citation statements)

References 10 publications

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“…These mechanisms include glucose auto-oxidation, increased glucose flux through the polyol pathway, non-enzymatic and progressive glycation of proteins and the formation of advanced glycosylation end products (AGEs). 20 An increase in the polyol pathway depletes the NADPH, which is utilised by the enzyme aldose reductase that catalyses the conversion of glucose to sorbitol. 2 Numerous studies have reported increased oxidative stress in type 2 diabetes mellitus patients compared with their healthy counterparts.…”

Section: Introductionmentioning

confidence: 99%

Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients

Ganjifrockwala

Joseph

George

2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Background: Chronic hyperglycaemia in diabetes mellitus leads to increased lipid peroxidation in the body, followed by the development of chronic complications due to oxidative stress. Objective: The aim of this study was to compare total antioxidant (TAO) levels and oxidative stress in type 2 diabetes mellitus (T2DM) patients with that of healthy controls without diabetes. Methods: A total of 98 participants (57 T2DM and 41 healthy people) gave their consent and participated in the study. Routine biochemical methods were used for fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c) and lipid profile measurements. Serum TAO levels, malondialdehyde (MDA), oxidised low-density lipoprotein (ox-LDL) levels and superoxide dismutase (SOD) activity were analysed using standard commercial reagent kits. Results: A significant rise in FPG, HbA1c, triglycerides, MDA and ox-LDL, and a significant reduction in TAO and high-density lipoprotein cholesterol (HDL-C) was observed in T2DM patients compared with controls. A significant negative relationship was observed between TAO levels and MDA levels in the T2DM group. Increased lipid peroxidation and reduced antioxidant levels were observed in T2DM patients. Conclusion: Early management through an antioxidant-rich diet and lifestyle changes in T2DM patients would help to avert the debilitating complications of diabetes.

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Section: Introductionmentioning

confidence: 99%

Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients

Ganjifrockwala

Joseph

George

2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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“…Eremomastax speciosa also, reduced (p < 0.05) malondialdehyde equivalent in the treated rats. Malondialdehyde, product of lipid peroxidation, causes DNA fragmentation and plasma membrane damage which will lead to cell death [6,37]. The decrease in the level of malondialdehyde suggests that ESE inhibits lipid peroxidation and thus may prevent development of cardiovascular disease [38].…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats

Onoja¹,

Effiong²,

Chukwuocha³

et al. 2020

Trop. J. Pharm Res

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Purpose: To investigate the antihyperglycemic, anti-dyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats. Methods: Hydromethanol extract of Eremomastax speciosa leaf was tested at dose range of 25 to 100 mg/kg against vehicle (distilled water) and glibenclamide (2 mg/kg, reference standard) in alloxaninduced hyperglycemic rats. Gas chromatography mass spectrometry (GC-MS) was employed in the identification of phytoconstituents. The fasting blood glucose (FBG), serum lipid profile, malondialdehyde, catalase and superoxide dismutase levels as well as the histopathology of the pancreas of the animals were evaluated. Results: The extract (25 mg/kg) significantly reduced FBG, lipid profile and malondialdehyde levels relative to vehicle treated group but increased the superoxide dismutase and catalase levels and reversed alloxan-induced pancreatic islet cell degeneration. GC-MS analysis showed the presence of 4,5-dimethylthiazole (4.38%), benzenesulfonic acid, methyl ester (15.62%), benzenesulfonyl chloride (40.62%), benzopyran-4-one, 5,7-dihydroxy-2-phenyl- (21.25%), 2(5H)-furanone, 4-methoxy-5-phenyl-(12.50%), and p-chlorobenzenesulfonyl chloride (5.62%) Conclusion: The hypoglycemic effect of the extract validates the folkloric uses of E. speciosa leaf in the ethnobotanical care of diabetes mellitus. Keywords: antihyperglycemic, antioxidant, anti-dyslipidemic, Eremomastax speciosa

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Neuroprotective effect of Bauhinia variegata Linn. leaf extracts in streptozotocin induced diabetes in Sprague Dawley rats

Laddha

Garud

Kulkarni

2021

J Diabetes Metab Disord

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Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer

Cited by 21 publications

References 10 publications

Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients

Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients

Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats

Neuroprotective effect of Bauhinia variegata Linn. leaf extracts in streptozotocin induced diabetes in Sprague Dawley rats

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