Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice

Relationship between trace metal concentration and antioxidative activity of ancient rice bran (red and black rice) and a present-day rice bran (Koshihikari)

“…Trace metals such as Mn, Cu and Zn are found in the active sites of SOD and catalase [33,34]. That the antioxidative properties due to such metal complexes (especially Mn) cooperate with some polyphenol compounds was suggested [35].…”

The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review

“…14 CAT is mainly located in the peroxisomes, and it is capable of removing intracellular H 2 O 2 and superoxide radicals with great efficacy. 4,10,15 Salivary levels of CAT were reduced in chronic periodontitis patients when compared to periodontally healthy subjects. 16 GPx is a selenium-containing peroxidase responsible for the protection of mammalian cells against oxidative damages by reducting a variety of hydroperoxides, such as ROOH and H 2 O 2 extracellularly and in the mitochondria.…”

Oxidants, antioxidants and the ischemic brain

“…There are two major limitations to the use of transgenic mice in study of oxidative stress. First, compensatory mechanisms, perhaps developed during ontogeny so as to allow survival in the absence/overexpression of the gene, are rarely considered, particularly in the context of the experiment being performed (Ibrahim et al, 2000;Przedborski et al, 1992). Second, although progress is being made in the use of conditional 'knock-outs' and 'overexpressors', in which a selected gene's expression is decreased/increased in response to a specific pharmacological stimulus, most work continues to be performed with animals that retain their knock-out (or overexpressing) status throughout the entire ischemia/reperfusion interval.…”