Antioxidant and neuroprotective properties of N-arachidonoyldopamine

Bobrov, M. Yu.; Lizhin, A. A.; Andrianova, Ekaterina L.; Gretskaya, N. M.; Frumkina, L. E.; Хаспеков, Л. Г.; Безуглов, В. В.

doi:10.1016/j.neulet.2007.11.010

Cited by 45 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The novel properties of NADA as an antioxidant and neuroprotectant have been discovered [77], and NADA has been shown to induce TRPV1-dependent cell death in neurone-like cells independent of caspase activity [78]. Studies indicate that the CB1 receptor is implicated in brain and neuronal development [79].…”

Section: Resultsmentioning

confidence: 99%

Metabolomic insights into system-wide coordination of vertebrate metamorphosis

et al. 2014

View full text Add to dashboard Cite

BackgroundAfter completion of embryogenesis, many organisms experience an additional obligatory developmental transition to attain a substantially different juvenile or adult form. During anuran metamorphosis, the aquatic tadpole undergoes drastic morphological changes and remodelling of tissues and organs to become a froglet. Thyroid hormones are required to initiate the process, but the mechanism whereby the many requisite changes are coordinated between organs and tissues is poorly understood. Metabolites are often highly conserved biomolecules between species and are the closest reflection of phenotype. Due to the extensive distribution of blood throughout the organism, examination of the metabolites contained therein provides a system-wide overview of the coordinated changes experienced during metamorphosis. We performed an untargeted metabolomic analysis on serum samples from naturally-metamorphosing Rana catesbeiana from tadpoles to froglets using ultraperformance liquid chromatography coupled to a mass spectrometer. Total and aqueous metabolite extracts were obtained from each serum sample to select for nonpolar and polar metabolites, respectively, and selected metabolites were validated by running authentic compounds.ResultsThe majority of the detected metabolites (74%) showed statistically significant abundance changes (padj < 0.001) between metamorphic stages. We observed extensive remodelling of five core metabolic pathways: arginine and purine/pyrimidine, cysteine/methionine, sphingolipid, and eicosanoid metabolism and the urea cycle, and found evidence for a major role for lipids during this postembryonic process. Metabolites traditionally linked to human disease states were found to have biological linkages to the system-wide changes occuring during the events leading up to overt morphological change.ConclusionsTo our knowledge, this is the first wide-scale metabolomic study of vertebrate metamorphosis identifying fundamental pathways involved in the coordination of this important developmental process and paves the way for metabolomic studies on other metamorphic systems including fish and insects.

show abstract

Section: Resultsmentioning

confidence: 99%

Metabolomic insights into system-wide coordination of vertebrate metamorphosis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…NADA has been found to play a regulatory role in both the peripheral and central nervous systems and displays antioxidant and neuroprotectant properties (34, 38 -41). In addition to its neurological effects, NADA has been implicated in smooth muscle contraction and vasorelaxation in blood vessels (42)(43)(44)(45). Additionally, NADA has been observed to suppress inflammatory activation of human Jurkat T-cells and to inhibit the release of prostaglandin E 2 (PGE 2 ) from LPS-activated astrocytes, microglia and mouse brain ECs (46 -48).…”

mentioning

confidence: 99%

The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells

Wilhelmsen

Khakpour

Tran

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background:The endothelium is centrally involved in acute inflammatory disorders. Results: WIN55,212-2 and the endocannabinoid N-arachidonoyl dopamine (NADA), but not anandamide nor 2-arachidonoylglycerol, reduce endothelial activation by bacterial Toll-like receptor agonists and TNF␣. Conclusion: NADA is a newly identified endogenous regulator of endothelial inflammation. Significance: The endothelial endocannabinoid system represents a novel immune regulatory system that could be exploited therapeutically.

show abstract

“…TRPV1 are activated by anandamide as well as Narachidonoyl-dopamine (NADA), which is formed by DA linked to arachidonic acid by an amide bond, conferring properties of endocannabinoid and endovanilloid ligand [282]. This mechanism consists in the conjugation of arachidonic acid directly with DA [283]; while the role of this compound is not fully understood, recent evidence supports the possibility that it may be an antioxidant and exert neuroprotective properties [284]. Notably, anandamide has been shown to inhibit DAT through a mechanism not dependent on G-protein-coupled proteins [285], which may be related to the activation of TRPV1 receptors.…”

Section: Mechanisms Of Interactions Of Cannabinoids and Atssmentioning

confidence: 99%

Interactions of Cannabis and Amphetamine-Type Stimulants

Tambaro

Bortolato

2015

Cannabinoid Modulation of Emotion, Memory, and Motivation

View full text Add to dashboard Cite

Amphetamine-type stimulants (ATSs) are a large family of substances of abuse, characterized by well-known mood-and performance-enhancing properties. This class encompasses several high-potency stimulants and entactogens, such as the precursor compound d-amphetamine (AMPH), its synthetic N-methylated derivatives methamphetamine (METH) and 3, 4-methylenedioxy-N-methylamphetamine (MDMA, or "ecstasy"), as well as novel designer drugs, based on substituted forms of the natural alkaloid cathinone. ATSs (and in particular METH) are among the most commonly abused substances worldwide, second only to Cannabis sativa; indeed, the rate of concurrent consumption of METH and cannabis has been increasing over the last decade, particularly among adolescents. Anecdotal evidence suggests that marijuana may offset some unpleasant subjective effects of ATSs, such as anxiety and paranoia. Both drugs have been shown to increase schizophrenia vulnerability in young vulnerable individuals, raising the possibility that their concurrent intake may have synergistic effects with respect to the development of psychotic manifestations. In addition, the combination of these two substances may affect their subjective effects and exacerbate their abuse liability. Although current evidence on the neurobiological interactions of cannabis and ATSs remains mostly elusive, initial studies in animal models suggest that the cannabinoid system may play a relevant role in the motivational and addictive properties of ATSs; furthermore, cannabinoids may modify the behavioral effects and even attenuate some untoward long-term consequences of ATSs. In this chapter we review the available evidence on these potential interactions and outline some key mechanisms that may account for the mutual modulatory influence of these substances.

show abstract

Antioxidant and neuroprotective properties of N-arachidonoyldopamine

Cited by 45 publications

References 26 publications

Metabolomic insights into system-wide coordination of vertebrate metamorphosis

Metabolomic insights into system-wide coordination of vertebrate metamorphosis

The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine (NADA) and Synthetic Cannabinoid WIN55,212-2 Abate the Inflammatory Activation of Human Endothelial Cells

Interactions of Cannabis and Amphetamine-Type Stimulants

Contact Info

Product

Resources

About