Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine

Bobrov, M. Yu.; Lyzhin, A. A.; Andrianova, Ekaterina L.; Gretskaya, N. M.; Зинченко, Г. Н.; Frumkina, L. E.; Хаспеков, Л. Г.; Безуглов, В. В.

doi:10.1007/s10517-006-0383-x

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…One explanation for this asymmetry involves the greater availability dopamine, a neurotransmitter shown to have neuroprotective effects, in the right than in the left caudate (Bobrov et al, 2006; Shih et al, 2007; Vernaleken et al, 2007). It is possible that the increased dopamine in the right caudate reduces the vulnerability of this structure to the stress-induced neurotoxic damage associated with depression.…”

Section: Discussionmentioning

confidence: 99%

Reduced caudate gray matter volume in women with major depressive disorder

Kim

Hamilton

Gotlib

2008

Psychiatry Research: Neuroimaging

158

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Previous brain imaging studies have reported that Major Depressive Disorder (MDD) is characterized by decreased volumes of several cortical and subcortical structures, including the hippocampus, amygdala, anterior cingulate cortex, and caudate nucleus. The purpose of the present study was to identify structural volumetric differences between MDD and healthy participants using a method that allows a comparison of gray and white matter volume across the whole brain. In addition, we explored the relation between symptom severity and brain regions with decreased volumes in MDD participants. Twenty-two women diagnosed with MDD and 25 healthy women with no history of major psychiatric disorders participated in this study. Magnetic resonance brain images were analyzed using optimized voxel-based morphometry to examine group differences in regional gray and white matter volume. Compared with healthy controls, MDD participants were found to have decreased gray matter volume in the bilateral caudate nucleus and the thalamus. No group differences were found for white matter volume, nor were there significant correlations between gray matter volumes and symptom severity within the MDD group. The present results suggest that smaller volume of caudate nucleus may be related to the pathophysiology of MDD and may account for abnormalities of the cortico-striatal-pallido-thalamic loop in MDD.

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Section: Discussionmentioning

confidence: 99%

Reduced caudate gray matter volume in women with major depressive disorder

Kim

Hamilton

Gotlib

2008

Psychiatry Research: Neuroimaging

158

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“…A similar concept was described by Yehuda (2002) who suggested that N-(a-linolenoyl) tyrosine could potentially be used as an anti-Parkinson agent. Finally, Bobrov et al (2006) showed that DHA-dopamine exhibited antioxidant activity and produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. It also decelerated the development of Parkinson's disease-like symptoms in a MPTP (1-methyl-4-phenyl-1,2,3,6tetrahydropyridine) mouse model.…”

Section: Dopamine-and Other N-acyl-conjugates Of Dhamentioning

confidence: 98%

“…Dopamine (Shashoua and Hesse, 1996;Bisogno et al, 2000;Bezuglov et al, 2001;Bobrov et al, 2006;Ostroumova et al, 2010;Dang et al, 2011;Sakharova et al, 2012) P: rodent brain Fresh water hydra; see further text B: Hydra tissue development, mouse embryo development; uptake in mouse brain; antipyretic, analgesic, cataleptic in rats; FAAH inhibition; AEA uptake; inhibition of NO and cytokines; antioxidant and neuroprotective in rats, anti-Parkinson (see also text)…”

Section: Presence Shown In Species (P) Receptor Affinity Studies (R) mentioning

confidence: 99%

N‐acyl amines of docosahexaenoic acid and other n–3 polyunsatured fatty acids – from fishy endocannabinoids to potential leads

Meijerink

Balvers

Witkamp

2013

British J Pharmacology

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N–3 long‐chain polyunsaturated fatty acids (n–3 LC‐PUFAs), in particular α‐linolenic acid (18:3n‐3), eicosapentaenoic acid (EPA; 20:5n‐3) and docosahexaenoic acid (DHA; 22:6n‐3) are receiving much attention because of their presumed beneficial health effects. To explain these, a variety of mechanisms have been proposed, but their interactions with the endocannabinoid system have received relatively little attention so far. However, it has already been shown some time ago that consumption of n–3 LC‐PUFAs not only affects the synthesis of prototypic endocannabinoids like anandamide but also stimulates the formation of specific n–3 LC‐PUFA‐derived conjugates with ethanolamine, dopamine, serotonin or other amines. Some of these fatty amides show overlapping biological activities with those of typical endocannabinoids, whereas others possess distinct and sometimes largely unknown receptor affinities and other properties. The ethanolamine and dopamine conjugates of DHA have been the most investigated thus far. These mediators may provide promising new leads to the field of inflammatory and neurological disorders and for other pharmacological applications, including their use as carrier molecules for neurotransmitters to target the brain. Furthermore, combinations of n–3 LC‐PUFA‐derived fatty acid amides, their precursors and FAAH inhibitors offer possibilities to optimise their effects in health and disease. Linked Articles This article is part of a themed section on Cannabinoids. To view the other articles in this section visit &

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“…Bobrov et al showed that DHA-dopamine exhibited antioxidant activity and produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. It also decelerated the development of Parkinson's disease-like symptoms in a MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model [37].…”

Section: Cytoprotective Propertiesmentioning

confidence: 99%