Antioxidant and Larvicidal Activities of Tephrosia Egregia Sandw against Aedes Aegypti

Am, Arriaga; Jq, Lima; Jn, Edson; Oliveira, De; Tl, Lemos; Fonseca, A.; Gt, Malcher; Gm, Santiago; Mafezoli, Jair; Braz‐Filho, Raimundo

doi:10.1177/1934578x0900400417

Cited by 6 publications

(7 citation statements)

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“…Furthermore, the adverse effects of conventional insecticides on the environment and animals, including human [9], and the limited number of available insecticides [4][5][6] compel continued search for safer plant insecticides and larvicides [3] that could be used in the control of these diseases. Medicinal plant extracts and their constituents have proved to be biodegradable, have low mammalian toxicity and induction of resistance [3,10] while their activities were similar to those of the standard drugs, such as temephos and methoprene [11,12].…”

Section: Introductionmentioning

confidence: 99%

Activities of Some Nigerian Medicinal Plants against Aedes aegypti

Adebajo¹,

Famuyiwa²,

John³

et al. 2012

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Extracts and constituents of medicinal plants have proven to be biodegradable, had low mammalian toxicity and induction of resistance, and comparable activities to the standard drugs. Therefore, methanolic extracts of some plants that are termite resistant or used ethnomedically as antimalarial and febrifuge were evaluated for activities against 4th-instar larvae of Aedes aegypti. A 61 % of these plants with these properties demonstrated larvicidal activities and may confirm the usefulness of these properties in choosing plant larvicides. This is the first report of larvicidal activities of stem barks and leaves of Blighia sapida and Baphia nitida, stem barks of Markhamia tomentosa and Newboldia laevis, and whole plants of Euphorbia macrophylla. Extracts of B. sapida stem bark, Costus specious root and Xylopia aethiopica seed, with LC50 1.71, 1.47 and 1.49 mg/ml at 48 h, respectively, were the most active and had significant activities that were comparable to Endosulphan. Hence, they may be used as plant larvicides in the control of dengue and yellow fever

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Section: Introductionmentioning

confidence: 99%

Activities of Some Nigerian Medicinal Plants against Aedes aegypti

Adebajo¹,

Famuyiwa²,

John³

et al. 2012

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“…Plant products have been used against the vectors, and plant-derived products can act as larvicides [14]. Essential oils from plants like Lippia species [15] and Croton zehntneri [16], and various extracts and compounds [17,18] have been documented for larvicidal activity towards Aedes aegypti. As part of a continuous research program on plants from northeast Brazil, this work describes the isolation of the diterpenes zanzibaric acid and isoozic acid, and the sesquiterpene caryolane-1,9β-diol from the peel of the ripe fruits of H. courbaril, and the chemical composition of the essential oils from the peel of both ripe and unripe fruits of H. courbaril, as well as the evaluation of these oils for their larvicidal activity against A. aegypti.…”

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confidence: 99%

Chemical Constituents and Larvicidal Activity of Hymenaea courbaril Fruit Peel

et al. 2010

Natural Product Communications

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The chemical compositions of the essential oils from the peel of ripe and unripe fruits of Hymenaea courbaril L., obtained by hydrodistillation, were analyzed by GC and GC-MS. The main constituents of the essential oil from the peel of the ripe fruits were the sesquiterpenes α-copaene (11.1%), spathulenol (10.1%) and β-selinene (8.2%), while germacrene-D (31.9%), β-caryophyllene (27.1%) and bicyclogermacrene (6.5%) were the major compounds in the oil from unripe fruits. The essential oils were tested against Aedes aegypti larvae and showed LC 50 values of 14.8 ± 0.4 μg/mL and 28.4 ± 0.3 μg/mL for the ripe and unripe fruit peel oils, respectively. From the peel of the ripe fruits, the diterpenes zanzibaric acid and isoozic acid were isolated, along with the sesquiterpene caryolane-1,9β-diol. To the best of our knowledge, this is the first report of this sesquiterpene in the genus. The structures of all compounds isolated were identified on the basis of their spectral data (IR, MS, 1D-and 2D-NMR) and by comparison with literature spectral data.

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“…The result of the in vitro antioxidant activity of the ethyl acetate extracts of the leaves of T. bracteolata corroborates the fact that the Ethyl acetate fraction of stem of Tephrosia tinctoria exhibited significant antioxidant activity [21]. Other species of the Genus Tephrosia that have been studied that reveled their antioxidant activity includes: the ethanolic extract of Tephrosia purpurea [24, 25], ethyl acetate extracts of Tephrosia egregia [26], Tephrosia villosa [27], the ethanol ether extract of Tephrosia vogelii seeds [28].…”

Section: Resultsmentioning

confidence: 54%

Antidiabetic, antioxidant and antimicrobial activities of extracts of Tephrosia bracteolata leaves

Egharevba

Dosumu

Atolanı

et al. 2019

Heliyon

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Aims Plant extracts have long been used for the ethnomedical treatment of diabetes, microbial infections and as a source of antioxidant. This study was aimed at investigating the antidiabetic, antioxidant, and antimicrobial activities of the n-hexane and ethyl acetate extract of Tephrosia bracteolata leaves (TBL) as associated with the ethnobotanical knowledge of the local people of Nigeria. Main methods The phytochemical composition of the n-hexane and ethyl acetate extract of the leaves of T. bracteolata were determined following standard procedures in literature, and it's in vitro inhibitory activities against α-glucosidase enzyme. 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS .+ ) and 1,1-diphenyl-2-picrylhydrazyl (DPPH + ) antioxidant activities were also examined. Well diffusion method was employed in evaluating the antimicrobial property of the extracts. Key findings The ethyl acetate extract of T. bracteolata leaves had the greatest inhibitory effect on α-glucosidase, followed by the n-hexane with IC 50 43.95 μg/ml and IC 50 ˃50 μg/ml respectively. The ethyl acetate also exhibited significant DPPH + and ABTS .+ antioxidant activity with IC 50 of 24.96 μg/ml and 6.48 μg/ml as compared to Ascorbic acid and Trolox (12.24 μg/ml and 5.91 μg/ml) respectively. The zones of inhibition of the ethyl acetate extract of T. bracteolata leaves ranges from 10 – 25 mm at a concentration of 6.25–200 mg/ml, and it showed a greater antibacterial activity than the n-hexane extract, having a zone of inhibition from 10 – 20 mm at concentration of 12.5–200 mg/ml when compared to the standard Gentamycin. Similarly, the ethyl acetate extract of T. bracteolata showed a better anti fungi activity at concentration range 12.5–200 mg/ml than the n-hexane extract at concentration range of 25–200 mg/ml with reference to Tioconazole. These results indicated for the first time that the ethyl acetate extract of T. bracteolata leaves extracts exerted potent inhibitory effects against α-glucosidase, actively scavenge DPPH + and ABTS .+ free radicals and successfully inhibits the proliferation of Gram positive and Gram negative microorganism. Significance TBL is an important source of antidiabetic, antimicrobial and antioxidant agent.

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Antioxidant and Larvicidal Activities of Tephrosia Egregia Sandw against Aedes Aegypti

Cited by 6 publications

References 9 publications

Activities of Some Nigerian Medicinal Plants against <i>Aedes aegypti</i>

Activities of Some Nigerian Medicinal Plants against <i>Aedes aegypti</i>

Chemical Constituents and Larvicidal Activity of Hymenaea courbaril Fruit Peel

Antidiabetic, antioxidant and antimicrobial activities of extracts of Tephrosia bracteolata leaves

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Antioxidant and Larvicidal Activities of Tephrosia Egregia Sandw against Aedes Aegypti

Cited by 6 publications

References 9 publications

Activities of Some Nigerian Medicinal Plants against &lt;i&gt;Aedes aegypti&lt;/i&gt;

Activities of Some Nigerian Medicinal Plants against &lt;i&gt;Aedes aegypti&lt;/i&gt;

Chemical Constituents and Larvicidal Activity of Hymenaea courbaril Fruit Peel

Antidiabetic, antioxidant and antimicrobial activities of extracts of Tephrosia bracteolata leaves

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Activities of Some Nigerian Medicinal Plants against <i>Aedes aegypti</i>

Activities of Some Nigerian Medicinal Plants against <i>Aedes aegypti</i>