Antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic Cladosporium velox and their relationship with its host plant Tinospora cordifolia

Singh, Balbir; Sharma, Prince; Kumar, Arun; Chadha, Pooja; Kaur, Ramandeep; Kaur, Amarjeet

doi:10.1016/j.jep.2016.10.018

Cited by 35 publications

(33 citation statements)

References 43 publications

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“…For instance, phenolic compounds are known for their antioxidant [25], antihypertensive, antidiabetic [26] and antimicrobial [27] abilities and hence, when present in hydrolysates, can interfere with the biological activities being assayed. Phenolic compounds could be separated from food proteins using methods such as ethanol extraction [24], supercritical carbon dioxide [28] pressurized water extraction [29], ultrasound-assisted extraction [30] and acetone extraction [31] prior to enzymatic hydrolysis.…”

Section: Production and Processing Of Food Protein-derived Bioactimentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

396

254

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The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health. For this reason, the search for food-derived bioactive peptides has increased exponentially. Over the years, many potential bioactive peptides from food have been documented; yet, obstacles such as the need to establish optimal conditions for industrial scale production and the absence of well-designed clinical trials to provide robust evidence for proving health claims continue to exist. Other important factors such as the possibility of allergenicity, cytotoxicity and the stability of the peptides during gastrointestinal digestion would need to be addressed. This review discusses our current knowledge on the health effects of food-derived bioactive peptides, their processing methods and challenges in their development.

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Section: Production and Processing Of Food Protein-derived Bioactimentioning

confidence: 99%

Bioactive Peptides

Daliri

Lee

2017

Foods

396

254

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“…Moreover, caffeic acid was found in metabolite profiles of isolates assigned to the genera Talaromyces and Paraphoma. This well-known phenol has been previously found in endophytic fungi Cladosporium velox (Singh et al, 2016), Penicillium canescens and Fusarium chlamydosporum (Das et al, 2018). Antibacterial, antifungal and modulatory effects of caffeic acid have been shown in previous studies (Lima et al, 2016).…”

Section: Discussionmentioning

confidence: 68%

Endophytic Fungi of Native Salvia abrotanoides Plants Reveal High Taxonomic Diversity and Unique Profiles of Secondary Metabolites

et al. 2020

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Endophytic fungi are often embedded in their host's metabolic networks, which can result in alterations of metabolite production and higher amounts of active compounds in medicinal plants. This study reports the occurrence, diversity, and secondary metabolite profiles of endophytic fungi isolated from Salvia abrotanoides plants obtained from three geographically distinct sites in Iran. A total of 56 endophytic fungi were isolated from roots and leaves of S. abrotanoides; site-specificity and root-dominated colonization was found to be a general characteristic of the endophytes. Based on molecular identification, the endophytic fungi were classified into 15 genera. Mycelial extracts of these isolates were subjected to high-resolution mass spectrometry analyses and revealed a broad spectrum of secondary metabolites. Our results demonstrated that Penicillium canescens, P. murcianum, Paraphoma radicina, and Coniolariella hispanica are producers of cryptotanshinone, which is a main bioactive compound of S. abrotanoides. Moreover, it was shown that it can be produced independent of the host plant. The effect of exogenous gibberellin on S. abrotanoides and endophytic fungi was shown to have a positive effect on increasing the cryptotanshinone production in the plant as well as in endophytic fungi cultivated under axenic conditions. Our findings provide further evidence that endophytic fungi play an important role in the production plant bioactive metabolites. Moreover, they provide an exploitable basis to increase cryptotanshinone production in S. abrotanoides.

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“…Therefore, EEHP could be considered as not mutagenic in vitro. There are many studies on the mutagenicity of plant extracts with the Ames test (Eren & Ozata, 2014;Ortega et al, 2016;Shafaei et al, 2015;Singha et al, 2016;Srividya et al, 2013;Veloso Borgesa et al, 2016) Cytotoxicity-mediated genotoxicity are recommended to consider for study on herbal extracts and essential oils (Ferrer et al, 2014;Kovacs et al, 2009). In this study, cytotoxicity of EEHP was evaluated by MTT and trypan blue assay.…”

Section: Discussionmentioning

confidence: 97%

“…Therefore, EEHP could be considered as not mutagenic in vitro. There are many studies on the mutagenicity of plant extracts with the Ames test (Eren & Ozata, ; Ortega et al, ; Shafaei et al, ; Singha et al, ; Srividya et al, ; Veloso Borgesa et al, ), but so far, no study has evaluated mutagenicity of H. persicum . The result of the present study is supported by the previous studies reported that α‐pinene, β‐pinene, and α‐terpinene had no mutagenicity by Ames test with different strains of S. typhimurium (Gomes‐Carneiro, Felzenszwalb, & Paumgartten, ; Saverini et al, ).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity, genotoxicity, and mutagenicity potential of ethanolic extract of Heracleum persicum Desf. ex Fischer

Amani

Gandomi

Basti

et al. 2019

Journal of Food Safety

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Heracleum persicum is a traditional medicinal plant with several pharmaceutical and food applications. There is no well‐documented information regarding the safety profile of this plant. The aim of this study was to evaluate the genotoxic, mutagenic, and cytotoxic potential of ethanolic extract of H. persicum (EEHP). The EEHP induced DNA damage at concentrations higher than 0.25 mg/mL. DNA damage index of the EEHP at dose of 10 mg/mL was 25 times greater than that in negative control. A dose dependent increase was found in tail moment by increasing the concentration of the extract. No statistically significant difference was seen in revertant Salmonella typhimurium colonies, with or without S9, between sub‐inhibitory concentrations of EEHP and negative control (p < 0.05). The results of the MTT assay revealed that treatment by different concentrations of EEHP caused 60 to 100% reduction in cell viability. The survival of the lymphocytes was negatively affected by EEHP concentrations higher than 1 mg/mL as evaluated by trypan blue assay. The results of this study showed genotoxicity and cytotoxicity potential of EEHP on human lymphocytes, effect of the EEHP exhibited in this work, further studies are needed to decide about the mutagenicity hazard of this medicinal plant. Practical applications Heracleum persicum is used as flavoring agent and for miscellaneous remedial purposes in Iranian traditional medicine. These widespread applications are based on the public belief that this plant is efficient and safe due to its traditional usage for long centuries. Besides many pharmacological properties, there is low information about the safety profile of this plant. The results of this study showed that ethanolic extract of H. persicum (EEHP) caused DNA damage on human lymphocytes. Furthermore, cytotoxicity of the EEHP on human lymphocytes was seen. According to these results, it is worthwhile to raise consumer awareness that excessive consumption of food and pharmaceutical preparations containing high concentrations of this plant may pose a health risk.

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Antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic Cladosporium velox and their relationship with its host plant Tinospora cordifolia

Cited by 35 publications

References 43 publications

Bioactive Peptides

Bioactive Peptides

Endophytic Fungi of Native Salvia abrotanoides Plants Reveal High Taxonomic Diversity and Unique Profiles of Secondary Metabolites

Cytotoxicity, genotoxicity, and mutagenicity potential of ethanolic extract of Heracleum persicum Desf. ex Fischer

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