Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes

Wu, Ming; Luo, Xia; Xu, Xiaoqing; Wei, Wei; Yu, Mei; Jiang, Nan; Ye, Liming; Yang, Zhou; Fei, Xiaofan

doi:10.1016/s0254-6272(15)30089-3

Cited by 54 publications

(45 citation statements)

References 15 publications

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“…F. velutipes derived polysaccharides were found to possess many health promoting properties, such as antioxidant and anticancer activity, immunomodulation, hepatocyte protection and even the ability to treat learning and memory impairment (Pang et al, 2007; He and Zhang, 2013; Wu et al, 2014; Yang et al, 2015) (Zhang et al, 2013). Beta-glucan is one of the many interesting polysaccharides found in F. velutipes , having demonstrated anticancer properties (Smiderle et al, 2006).…”

Section: Chemical Composition and Nutritional Value Of F Velutipesmentioning

confidence: 99%

“…They include antitumour, anticancer and anti-atherosclerotic activity, thrombosis inhibition, antihypertensive and cholesterol lowering effects, anti-aging and antioxidant properties, ability to restore neurotransmitters associated with memory and learning, anti-inflammatory, immunomodulatory and anti-bacterial activities (Gu and Leonard, 2006; Karaman et al, 2010; Lee et al, 2013; Wu et al, 2014; Rahman et al, 2015; Yang et al, 2015). These biological activities of F. velutipes are summarized in Table 6; a summary of the biological activities of F. velutipes in a graphical from is depicted in Figure 2.…”

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

“…Wu et al (2014) extracted polysaccharide, FVP 1-A from F. velutipes , which exhibited superoxide radical scavenging ability with an IC 50 value of about 10 mg/mL, hydroxyl radical scavenging ability with an IC 50 value of about 12 mg/mL and reducing power of 1.04, showing a high antioxidant capacity. At 200 μg/mL, polysaccharide from liquid culture mycelia extracted using double distilled water, displayed DPPH scavenging rate of 65.85% and hydroxyl radical scavenging rate of 71.24% (Zhao et al, 2013).…”

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

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Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

et al. 2016

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Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste. In recent decades, research has expanded beyond detailing its nutritional composition and delved into the biological activities and potential health benefits of its constituents. Many bioactive constituents from a range of families have been isolated from different parts of the mushroom, including carbohydrates, protein, lipids, glycoproteins, phenols, and sesquiterpenes. These compounds have been demonstrated to exhibit various biological activities, such as antitumour and anticancer activities, anti-atherosclerotic and thrombosis inhibition activity, antihypertensive and cholesterol lowering effects, anti-aging and antioxidant properties, ability to aid with restoring memory and overcoming learning deficits, anti-inflammatory, immunomodulatory, anti-bacterial, ribosome inactivation and melanosis inhibition. This review aims to consolidate the information concerning the phytochemistry and biological activities of various compounds isolated from F. velutipes to demonstrate that this mushroom is not only a great source of nutrients but also possesses tremendous potential in pharmaceutical drug development.

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Section: Chemical Composition and Nutritional Value Of F Velutipesmentioning

confidence: 99%

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

Section: Biological Activities Of F Velutipesmentioning

confidence: 99%

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Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

et al. 2016

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“…Cytokines serve important roles in cellular immune responses, and a variety of immune cell interactions are mediated by cytokines (8). The present study investigated the effects of SAP-1 and SAP-2 on the secretion and expression of cytokines by RAW264.7 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Macrophages are immune effector cells with defensive and regulatory functions, which actively phagocytose foreign antigens or pathogenic microorganisms, and trigger an immune response (7,8). A previous study demonstrated that the main components of Saccharum Alhagi are polysaccharides with antioxidant activities and in vivo immune activities (9,10).…”

Section: Introductionmentioning

confidence: 99%

Saccharum Alhagi polysaccharide-1 and -2 promote the immunocompetence of RAW264.7 macrophages inï¿½vitro

Xiang

Zhao

et al. 2018

Exp Ther Med

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Abstract. The in vitro immune activities of Saccharum Alhagi polysaccharides (SAP) have been previously studied. The present study aimed to investigate the effects of SAP-1 and SAP-2 on the activity of RAW264.7 mouse macrophages. RAW264.7 cells were treated with 150, 300 and 600 mg/l concentrations of SAP-1 (a 50% alcohol precipitation) and SAP-2 (an 80% alcohol precipitation) or with 10 mg/l lipopolysaccharide. Untreated cells were used as a negative control. An MTT assay was used to detect the proliferation of the cells, and Hoechst 33528 staining was conducted in order to visualize the cell nuclei. Additionally, the Griess method was used to measure nitric oxide (NO) levels. A neutral red uptake assay was performed to determine the phagocytic activity of the macrophages, and ELISAs were performed to detect cytokine levels. Furthermore, reverse transcription-quantitative polymerase chain reaction was used to measure the mRNA expression of certain cytokines. The results demonstrated that SAP increased the proliferative activity and activated the immune function of RAW264.7 cells, and was lacking in cytotoxicity. In addition, SAP-1 exhibited a stronger effect in promoting RAW264.7 cell proliferation than did SAP-2. Furthermore, SAP-1 and SAP-2 significantly increased the level of NO, with the effect of SAP-1 being stronger than that of SAP-2. SAP-1 increased the phagocytic activity of RAW264.7 cells and promoted the secretion of the cytokines interleukin (IL)-1β, IL-2 and tumor necrosis factor (TNF)-α by RAW264.7 cells, with an effect that was stronger than that of SAP-2. Finally, different concentrations of SAP-1 or SAP-2 had distinct effects in upregulating the expression of TNF-α, IL-1β, nuclear factor-κB and inducible nitric oxide synthase mRNA. The results of the present study demonstrate that SAP is capable of enhancing the immune activity of mouse macrophages.

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UHPLC‐Orbitrap‐Fusion‐TMS‐Based Metabolomics Study of Phenylpropionamides in the Seed of Cannabis sativa L. against Alzheimer's Disease

Liu

Guan

et al. 2023

Chemistry & Biodiversity

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Phenylpropionamides in the seed of Cannabis sativa L. (PHS) have a protective effect on neuroinflammation and antioxidant activity. In this study, the UHPLC‐Orbitrap‐fusion‐TMS‐based metabolomics approach was used to analyze the serum samples and identify potential biomarkers in Streptozotocin (STZ) induced Alzheimer's disease (AD) rats. The results revealed that primary bile acid biosynthesis and taurine and hypotaurine metabolism were significantly correlated with STZ‐induced AD rats. In addition, the key enzymes in these two pathways were verified at the protein level. The levels of cysteine dioxygenase type I (CDO1), cysteine sulfinic acid decarboxylase (CSAD), cysteamine (2‐aminoethanethiol) dioxygenase (ADO), 7α‐hydroxylase (CYP7A1), and sterol 12α‐hydroxylase (CYP8B1) were the key enzymes affecting the two pathways in AD rats compared with the control group (CON). Furthermore, after a high‐dose group of phenylpropionamides in the seed of Cannabis sativa L. (PHS−H) was administrated, the levels of CDO1, CSAD, CYP7A1, and CYP8B1 were all callback. These findings demonstrate for the first time that the anti‐AD effect of PHS is associated with the regulation of primary bile acid biosynthesis and taurine and hypotaurine metabolism in STZ‐induced AD rats.

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Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes

Cited by 54 publications

References 15 publications

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties

Saccharum Alhagi polysaccharide-1 and -2 promote the immunocompetence of RAW264.7 macrophages inï¿½vitro

UHPLC‐Orbitrap‐Fusion‐TMS‐Based Metabolomics Study of Phenylpropionamides in the Seed of Cannabis sativa L. against Alzheimer's Disease

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